A fluorescent peptidyl substrate for visualizing peptidyl-prolyl cis/trans isomerase activity in live cells

Quan Jiang; Xiao-Rong Li; Cheng-Kun Wang; Juan Cheng; Chao Tan; Tian-Tian Cui; Nan-Nan Lu; Tony D James; Feng Han; Xin Li

doi:10.1039/c7cc09135d

A fluorescent peptidyl substrate for visualizing peptidyl-prolyl cis/trans isomerase activity in live cells

Quan Jiang, Xiao-Rong Li, Cheng-Kun Wang, Juan Cheng, Chao Tan, Tian-Tian Cui, Nan-Nan Lu, Tony D James, Feng Han, Xin Li

Zhejiang University

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Abstract

This communication reports on a fluorescent probe (PPI-P) for imaging active peptidyl-prolyl cis/trans isomerases in live cells. PPI-P is capable of responding to both recombinant and cellular PPIases fluorogenically, and has been shown to specifically image active PPIases in live cells.

Original language	English
Pages (from-to)	1857-1860
Number of pages	4
Journal	Chemical communications (Cambridge, England)
Volume	54
Issue number	15
Early online date	23 Jan 2018
DOIs	https://doi.org/10.1039/c7cc09135d
Publication status	Published - 21 Feb 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c7cc09135d

PPIase probe - Final Author Acepted Version
The final publication is available at the Royal Society of Chemistry via 10.1039/c7cc09135d
Accepted author manuscript, 846 KB

Cite this

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title = "A fluorescent peptidyl substrate for visualizing peptidyl-prolyl cis/trans isomerase activity in live cells",

abstract = "This communication reports on a fluorescent probe (PPI-P) for imaging active peptidyl-prolyl cis/trans isomerases in live cells. PPI-P is capable of responding to both recombinant and cellular PPIases fluorogenically, and has been shown to specifically image active PPIases in live cells.",

author = "Quan Jiang and Xiao-Rong Li and Cheng-Kun Wang and Juan Cheng and Chao Tan and Tian-Tian Cui and Nan-Nan Lu and James, \{Tony D\} and Feng Han and Xin Li",

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T1 - A fluorescent peptidyl substrate for visualizing peptidyl-prolyl cis/trans isomerase activity in live cells

AU - Jiang, Quan

AU - Li, Xiao-Rong

AU - Wang, Cheng-Kun

AU - Cheng, Juan

AU - Tan, Chao

AU - Cui, Tian-Tian

AU - Lu, Nan-Nan

AU - James, Tony D

AU - Han, Feng

AU - Li, Xin

PY - 2018/2/21

Y1 - 2018/2/21

N2 - This communication reports on a fluorescent probe (PPI-P) for imaging active peptidyl-prolyl cis/trans isomerases in live cells. PPI-P is capable of responding to both recombinant and cellular PPIases fluorogenically, and has been shown to specifically image active PPIases in live cells.

AB - This communication reports on a fluorescent probe (PPI-P) for imaging active peptidyl-prolyl cis/trans isomerases in live cells. PPI-P is capable of responding to both recombinant and cellular PPIases fluorogenically, and has been shown to specifically image active PPIases in live cells.

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U2 - 10.1039/c7cc09135d

DO - 10.1039/c7cc09135d

M3 - Article

C2 - 29387835

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VL - 54

SP - 1857

EP - 1860

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

IS - 15

ER -

A fluorescent peptidyl substrate for visualizing peptidyl-prolyl cis/trans isomerase activity in live cells

Abstract

ASJC Scopus subject areas

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