Abstract
We have developed a fluorescent peptide conjugate (TrpNDIRGDfK) based on the coupling of cyclo(RGDfK) to a new tryptophan-tagged amino acid naphthalenediimide (TrpNDI). Confocal fluorescence microscopy coupled with fluorescence lifetime imaging (FLIM) mapping, single and two-photon fluorescence excitation, lifetime components and corresponding decay profiles were used as parameters able to investigate qualitatively the cellular behavior regarding the molecular environment and biolocalisation of TrpNDI and TrpNDI-RGDfK in cancer cells.
Original language | English |
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Pages (from-to) | 6901-6904 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 51 |
Issue number | 32 |
Early online date | 16 Jan 2015 |
DOIs | |
Publication status | Published - 25 Apr 2015 |