A golden clue to human skin colour variation

Jeanette Muller, Robert N. Kelsh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Variations in human skin pigmentation are obvious, but how have skin colour differences evolved? Although clearly a polymorphic trait, the number and identity of key variants has remained unclear. Investigation of pigmentation phenotypes in model organisms provides a route to identify these genes and showed MC1R to be one key locus. Now, cloning of a classic zebrafish mutant, golden, identifies slc24a5 as a gene involved in fish skin pigmentation.((1)) Strikingly this study identifies the human orthologue, SLC24A5, as likely to make a major contribution to the pale skin colouration of Western Europeans.
Original languageEnglish
Pages (from-to)578-582
JournalBioessays
Volume28
Issue number6
DOIs
Publication statusPublished - 2006

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Skin Pigmentation
Skin
Color
Genes
Pigmentation
Zebrafish
Organism Cloning
Cloning
Fishes
Fish
Phenotype

Cite this

A golden clue to human skin colour variation. / Muller, Jeanette; Kelsh, Robert N.

In: Bioessays, Vol. 28, No. 6, 2006, p. 578-582.

Research output: Contribution to journalArticle

Muller, Jeanette ; Kelsh, Robert N. / A golden clue to human skin colour variation. In: Bioessays. 2006 ; Vol. 28, No. 6. pp. 578-582.
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