A dual channel superoxide anion probe for the rapid visualization of scrap leather-induced neuroinflammation using an intramolecular electron transfer-integrated near-infrared platform

Xinjian Song; Xumei Wang; Lixia Bai; Chenchen Li; Li Chai; Haixian Ren; Jianbin Chen; Wei Hu; Tony D. James

doi:10.1016/j.snb.2024.136566

A dual channel superoxide anion probe for the rapid visualization of scrap leather-induced neuroinflammation using an intramolecular electron transfer-integrated near-infrared platform

Xinjian Song, Xumei Wang, Lixia Bai, Chenchen Li, Li Chai, Haixian Ren, Jianbin Chen, Wei Hu, Tony D. James

Research output: Contribution to journal › Article › peer-review

Abstract

Chemicals used in leather processing can penetrate the human skin and respiratory system, causing neuroinflammation and pose health risks. This study addresses the lack of effective treatments for this condition by focusing on the design and synthesis of a novel dual-channel fluorescence probe HMDP. HMDP, equipped with coumarin as the fluorophore, quinolinium ion as its mitochondrial localization group, and diphenylphosphinoyl as the O₂^•− recognition site, demonstrated significant dual-channel fluorescence amplification at 570 and 714 nm. Incorporating two non-interfering fluorescent channels enabled cross-verification, enhancing accuracy. This research systematically assessed fluctuations in O₂^•− levels in a cell oxidative stress model induced by scrap leather using HMDP. The results underscored the considerable potential of this mitochondrial-targeted near-infrared fluorescent probe for monitoring scrap leather-induced cell oxidative stress. This research contributes valuable insights into the neuroinflammatory effects induced by leather processing chemicals, providing a foundation for potential therapeutic interventions to mitigate health risks associated with such exposures.

Original language	English
Article number	136566
Number of pages	8
Journal	Sensors and Actuators B: Chemical
Volume	422
Early online date	3 Sept 2024
DOIs	https://doi.org/10.1016/j.snb.2024.136566
Publication status	Published - 1 Jan 2025

Data Availability Statement

Data will be made available on request.

Acknowledgements

We also would like to express my sincere gratitude to Professor Qiang for providing the scrap leather samples for this work. Professor Qiang generosity and assistance were invaluable in conducting our research.

Funding

XJS wishes to thank the National Natural Science Foundation of China (No. 22166017); HXR wishes to thank the National Natural Science Foundation of China (No. 22277104); JBC wishes to thank the National Natural Science Foundation of China (Nos. 22171154 and 22201152), the Special Funds of Taishan Scholar Project (No. tsqn202211206), the Youth Innovative Talents Recruitment and Cultivation Program of Shandong Higher Education, Jinan Science & Technology Bureau (No. 2021GXRC080). WH wishes to thank the Science and Technology Innovation Project of Higher Education in Shanxi Province (2023L292) and the Natural Science Foundation of Shanxi Province (202303021222233). TDJ wishes to thank the University of Bath and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University (2020ZD01) for support.

Keywords

Dual-channel fluorescence imaging
Neuroinflammation
Oxidative stress
Scrap leather
Superoxide anion radical sensitive probe

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.snb.2024.136566Licence: CC BY

Cite this

Song, X., Wang, X., Bai, L., Li, C., Chai, L., Ren, H., Chen, J., Hu, W., & James, T. D. (2025). A dual channel superoxide anion probe for the rapid visualization of scrap leather-induced neuroinflammation using an intramolecular electron transfer-integrated near-infrared platform. Sensors and Actuators B: Chemical, 422, Article 136566. https://doi.org/10.1016/j.snb.2024.136566

A dual channel superoxide anion probe for the rapid visualization of scrap leather-induced neuroinflammation using an intramolecular electron transfer-integrated near-infrared platform. / Song, Xinjian; Wang, Xumei; Bai, Lixia et al.
In: Sensors and Actuators B: Chemical, Vol. 422, 136566, 01.01.2025.

Research output: Contribution to journal › Article › peer-review

@article{e48212d498ad4391aabfd33d7bacd2c3,

title = "A dual channel superoxide anion probe for the rapid visualization of scrap leather-induced neuroinflammation using an intramolecular electron transfer-integrated near-infrared platform",

abstract = "Chemicals used in leather processing can penetrate the human skin and respiratory system, causing neuroinflammation and pose health risks. This study addresses the lack of effective treatments for this condition by focusing on the design and synthesis of a novel dual-channel fluorescence probe HMDP. HMDP, equipped with coumarin as the fluorophore, quinolinium ion as its mitochondrial localization group, and diphenylphosphinoyl as the O2•− recognition site, demonstrated significant dual-channel fluorescence amplification at 570 and 714 nm. Incorporating two non-interfering fluorescent channels enabled cross-verification, enhancing accuracy. This research systematically assessed fluctuations in O2•− levels in a cell oxidative stress model induced by scrap leather using HMDP. The results underscored the considerable potential of this mitochondrial-targeted near-infrared fluorescent probe for monitoring scrap leather-induced cell oxidative stress. This research contributes valuable insights into the neuroinflammatory effects induced by leather processing chemicals, providing a foundation for potential therapeutic interventions to mitigate health risks associated with such exposures.",

keywords = "Dual-channel fluorescence imaging, Neuroinflammation, Oxidative stress, Scrap leather, Superoxide anion radical sensitive probe",

author = "Xinjian Song and Xumei Wang and Lixia Bai and Chenchen Li and Li Chai and Haixian Ren and Jianbin Chen and Wei Hu and James, {Tony D.}",

year = "2025",

month = jan,

day = "1",

doi = "10.1016/j.snb.2024.136566",

language = "English",

volume = "422",

journal = "Sensors and Actuators B: Chemical",

issn = "0925-4005",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - A dual channel superoxide anion probe for the rapid visualization of scrap leather-induced neuroinflammation using an intramolecular electron transfer-integrated near-infrared platform

AU - Song, Xinjian

AU - Wang, Xumei

AU - Bai, Lixia

AU - Li, Chenchen

AU - Chai, Li

AU - Ren, Haixian

AU - Chen, Jianbin

AU - Hu, Wei

AU - James, Tony D.

PY - 2025/1/1

Y1 - 2025/1/1

N2 - Chemicals used in leather processing can penetrate the human skin and respiratory system, causing neuroinflammation and pose health risks. This study addresses the lack of effective treatments for this condition by focusing on the design and synthesis of a novel dual-channel fluorescence probe HMDP. HMDP, equipped with coumarin as the fluorophore, quinolinium ion as its mitochondrial localization group, and diphenylphosphinoyl as the O2•− recognition site, demonstrated significant dual-channel fluorescence amplification at 570 and 714 nm. Incorporating two non-interfering fluorescent channels enabled cross-verification, enhancing accuracy. This research systematically assessed fluctuations in O2•− levels in a cell oxidative stress model induced by scrap leather using HMDP. The results underscored the considerable potential of this mitochondrial-targeted near-infrared fluorescent probe for monitoring scrap leather-induced cell oxidative stress. This research contributes valuable insights into the neuroinflammatory effects induced by leather processing chemicals, providing a foundation for potential therapeutic interventions to mitigate health risks associated with such exposures.

AB - Chemicals used in leather processing can penetrate the human skin and respiratory system, causing neuroinflammation and pose health risks. This study addresses the lack of effective treatments for this condition by focusing on the design and synthesis of a novel dual-channel fluorescence probe HMDP. HMDP, equipped with coumarin as the fluorophore, quinolinium ion as its mitochondrial localization group, and diphenylphosphinoyl as the O2•− recognition site, demonstrated significant dual-channel fluorescence amplification at 570 and 714 nm. Incorporating two non-interfering fluorescent channels enabled cross-verification, enhancing accuracy. This research systematically assessed fluctuations in O2•− levels in a cell oxidative stress model induced by scrap leather using HMDP. The results underscored the considerable potential of this mitochondrial-targeted near-infrared fluorescent probe for monitoring scrap leather-induced cell oxidative stress. This research contributes valuable insights into the neuroinflammatory effects induced by leather processing chemicals, providing a foundation for potential therapeutic interventions to mitigate health risks associated with such exposures.

KW - Dual-channel fluorescence imaging

KW - Neuroinflammation

KW - Oxidative stress

KW - Scrap leather

KW - Superoxide anion radical sensitive probe

UR - http://www.scopus.com/inward/record.url?scp=85203445115&partnerID=8YFLogxK

U2 - 10.1016/j.snb.2024.136566

DO - 10.1016/j.snb.2024.136566

M3 - Article

AN - SCOPUS:85203445115

SN - 0925-4005

VL - 422

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

M1 - 136566

ER -

A dual channel superoxide anion probe for the rapid visualization of scrap leather-induced neuroinflammation using an intramolecular electron transfer-integrated near-infrared platform

Abstract

Data Availability Statement

Acknowledgements

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this