A downy mildew effector evades recognition by polymorphism of expression and subcellular localization

Shuta Asai, Oliver J Furzer, Volkan Cevik, Dae Sung Kim, Naveed Ishaque, Sandra Goritschnig, Brian J Staskawicz, Ken Shirasu, Jonathan D G Jones

Research output: Contribution to journalArticle

Abstract

Pathogen co-evolution with plants involves selection for evasion of host surveillance systems. The oomycete Hyaloperonospora arabidopsidis (Hpa) causes downy mildew on Arabidopsis, and race-specific interactions between Arabidopsis accessions and Hpa isolates fit the gene-for-gene model in which host resistance or susceptibility are determined by matching pairs of plant Resistance (R) genes and pathogen Avirulence (AVR) genes. Arabidopsis Col-0 carries R gene RPP4 that confers resistance to Hpa isolates Emoy2 and Emwa1, but its cognate recognized effector(s) were unknown. We report here the identification of the Emoy2 AVR effector gene recognized by RPP4 and show resistance-breaking isolates of Hpa on RPP4-containing Arabidopsis carry the alleles that either are not expressed, or show cytoplasmic instead of nuclear subcellular localization.

LanguageEnglish
Article number5192
Pages1-11
Number of pages11
JournalNature Communications
Volume9
Issue number1
DOIs
StatusPublished - 5 Dec 2018

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Asai, S., Furzer, O. J., Cevik, V., Kim, D. S., Ishaque, N., Goritschnig, S., ... Jones, J. D. G. (2018). A downy mildew effector evades recognition by polymorphism of expression and subcellular localization. Nature Communications, 9(1), 1-11. [5192]. https://doi.org/10.1038/s41467-018-07469-3

A downy mildew effector evades recognition by polymorphism of expression and subcellular localization. / Asai, Shuta; Furzer, Oliver J; Cevik, Volkan; Kim, Dae Sung; Ishaque, Naveed; Goritschnig, Sandra; Staskawicz, Brian J; Shirasu, Ken; Jones, Jonathan D G.

In: Nature Communications, Vol. 9, No. 1, 5192, 05.12.2018, p. 1-11.

Research output: Contribution to journalArticle

Asai, S, Furzer, OJ, Cevik, V, Kim, DS, Ishaque, N, Goritschnig, S, Staskawicz, BJ, Shirasu, K & Jones, JDG 2018, 'A downy mildew effector evades recognition by polymorphism of expression and subcellular localization', Nature Communications, vol. 9, no. 1, 5192, pp. 1-11. https://doi.org/10.1038/s41467-018-07469-3
Asai, Shuta ; Furzer, Oliver J ; Cevik, Volkan ; Kim, Dae Sung ; Ishaque, Naveed ; Goritschnig, Sandra ; Staskawicz, Brian J ; Shirasu, Ken ; Jones, Jonathan D G. / A downy mildew effector evades recognition by polymorphism of expression and subcellular localization. In: Nature Communications. 2018 ; Vol. 9, No. 1. pp. 1-11.
@article{b56dad4a93a0427c99ae7e1c32a5f992,
title = "A downy mildew effector evades recognition by polymorphism of expression and subcellular localization",
abstract = "Pathogen co-evolution with plants involves selection for evasion of host surveillance systems. The oomycete Hyaloperonospora arabidopsidis (Hpa) causes downy mildew on Arabidopsis, and race-specific interactions between Arabidopsis accessions and Hpa isolates fit the gene-for-gene model in which host resistance or susceptibility are determined by matching pairs of plant Resistance (R) genes and pathogen Avirulence (AVR) genes. Arabidopsis Col-0 carries R gene RPP4 that confers resistance to Hpa isolates Emoy2 and Emwa1, but its cognate recognized effector(s) were unknown. We report here the identification of the Emoy2 AVR effector gene recognized by RPP4 and show resistance-breaking isolates of Hpa on RPP4-containing Arabidopsis carry the alleles that either are not expressed, or show cytoplasmic instead of nuclear subcellular localization.",
author = "Shuta Asai and Furzer, {Oliver J} and Volkan Cevik and Kim, {Dae Sung} and Naveed Ishaque and Sandra Goritschnig and Staskawicz, {Brian J} and Ken Shirasu and Jones, {Jonathan D G}",
year = "2018",
month = "12",
day = "5",
doi = "10.1038/s41467-018-07469-3",
language = "English",
volume = "9",
pages = "1--11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - A downy mildew effector evades recognition by polymorphism of expression and subcellular localization

AU - Asai, Shuta

AU - Furzer, Oliver J

AU - Cevik, Volkan

AU - Kim, Dae Sung

AU - Ishaque, Naveed

AU - Goritschnig, Sandra

AU - Staskawicz, Brian J

AU - Shirasu, Ken

AU - Jones, Jonathan D G

PY - 2018/12/5

Y1 - 2018/12/5

N2 - Pathogen co-evolution with plants involves selection for evasion of host surveillance systems. The oomycete Hyaloperonospora arabidopsidis (Hpa) causes downy mildew on Arabidopsis, and race-specific interactions between Arabidopsis accessions and Hpa isolates fit the gene-for-gene model in which host resistance or susceptibility are determined by matching pairs of plant Resistance (R) genes and pathogen Avirulence (AVR) genes. Arabidopsis Col-0 carries R gene RPP4 that confers resistance to Hpa isolates Emoy2 and Emwa1, but its cognate recognized effector(s) were unknown. We report here the identification of the Emoy2 AVR effector gene recognized by RPP4 and show resistance-breaking isolates of Hpa on RPP4-containing Arabidopsis carry the alleles that either are not expressed, or show cytoplasmic instead of nuclear subcellular localization.

AB - Pathogen co-evolution with plants involves selection for evasion of host surveillance systems. The oomycete Hyaloperonospora arabidopsidis (Hpa) causes downy mildew on Arabidopsis, and race-specific interactions between Arabidopsis accessions and Hpa isolates fit the gene-for-gene model in which host resistance or susceptibility are determined by matching pairs of plant Resistance (R) genes and pathogen Avirulence (AVR) genes. Arabidopsis Col-0 carries R gene RPP4 that confers resistance to Hpa isolates Emoy2 and Emwa1, but its cognate recognized effector(s) were unknown. We report here the identification of the Emoy2 AVR effector gene recognized by RPP4 and show resistance-breaking isolates of Hpa on RPP4-containing Arabidopsis carry the alleles that either are not expressed, or show cytoplasmic instead of nuclear subcellular localization.

UR - http://www.scopus.com/inward/record.url?scp=85057965578&partnerID=8YFLogxK

U2 - 10.1038/s41467-018-07469-3

DO - 10.1038/s41467-018-07469-3

M3 - Article

VL - 9

SP - 1

EP - 11

JO - Nature Communications

T2 - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 5192

ER -