A downy mildew effector evades recognition by polymorphism of expression and subcellular localization

Shuta Asai; Oliver J Furzer; Volkan Cevik; Dae Sung Kim; Naveed Ishaque; Sandra Goritschnig; Brian J Staskawicz; Ken Shirasu; Jonathan D G Jones

doi:10.1038/s41467-018-07469-3

A downy mildew effector evades recognition by polymorphism of expression and subcellular localization

Shuta Asai, Oliver J Furzer, Volkan Cevik, Dae Sung Kim, Naveed Ishaque, Sandra Goritschnig, Brian J Staskawicz, Ken Shirasu, Jonathan D G Jones

Research output: Contribution to journal › Article › peer-review

31 Citations (SciVal)

Abstract

Pathogen co-evolution with plants involves selection for evasion of host surveillance systems. The oomycete Hyaloperonospora arabidopsidis (Hpa) causes downy mildew on Arabidopsis, and race-specific interactions between Arabidopsis accessions and Hpa isolates fit the gene-for-gene model in which host resistance or susceptibility are determined by matching pairs of plant Resistance (R) genes and pathogen Avirulence (AVR) genes. Arabidopsis Col-0 carries R gene RPP4 that confers resistance to Hpa isolates Emoy2 and Emwa1, but its cognate recognized effector(s) were unknown. We report here the identification of the Emoy2 AVR effector gene recognized by RPP4 and show resistance-breaking isolates of Hpa on RPP4-containing Arabidopsis carry the alleles that either are not expressed, or show cytoplasmic instead of nuclear subcellular localization.

Original language	English
Article number	5192
Pages (from-to)	1-11
Number of pages	11
Journal	Nature Communications
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41467-018-07469-3
Publication status	Published - 5 Dec 2018

ASJC Scopus subject areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/s41467-018-07469-3Licence: CC BY

Cite this

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abstract = "Pathogen co-evolution with plants involves selection for evasion of host surveillance systems. The oomycete Hyaloperonospora arabidopsidis (Hpa) causes downy mildew on Arabidopsis, and race-specific interactions between Arabidopsis accessions and Hpa isolates fit the gene-for-gene model in which host resistance or susceptibility are determined by matching pairs of plant Resistance (R) genes and pathogen Avirulence (AVR) genes. Arabidopsis Col-0 carries R gene RPP4 that confers resistance to Hpa isolates Emoy2 and Emwa1, but its cognate recognized effector(s) were unknown. We report here the identification of the Emoy2 AVR effector gene recognized by RPP4 and show resistance-breaking isolates of Hpa on RPP4-containing Arabidopsis carry the alleles that either are not expressed, or show cytoplasmic instead of nuclear subcellular localization.",

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AU - Asai, Shuta

AU - Furzer, Oliver J

AU - Cevik, Volkan

AU - Kim, Dae Sung

AU - Ishaque, Naveed

AU - Goritschnig, Sandra

AU - Staskawicz, Brian J

AU - Shirasu, Ken

AU - Jones, Jonathan D G

PY - 2018/12/5

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AB - Pathogen co-evolution with plants involves selection for evasion of host surveillance systems. The oomycete Hyaloperonospora arabidopsidis (Hpa) causes downy mildew on Arabidopsis, and race-specific interactions between Arabidopsis accessions and Hpa isolates fit the gene-for-gene model in which host resistance or susceptibility are determined by matching pairs of plant Resistance (R) genes and pathogen Avirulence (AVR) genes. Arabidopsis Col-0 carries R gene RPP4 that confers resistance to Hpa isolates Emoy2 and Emwa1, but its cognate recognized effector(s) were unknown. We report here the identification of the Emoy2 AVR effector gene recognized by RPP4 and show resistance-breaking isolates of Hpa on RPP4-containing Arabidopsis carry the alleles that either are not expressed, or show cytoplasmic instead of nuclear subcellular localization.

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A downy mildew effector evades recognition by polymorphism of expression and subcellular localization

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Volkan Cevik

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A downy mildew effector evades recognition by polymorphism of expression and subcellular localization

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Volkan Cevik

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