A direct synthesis of 2-deoxy-2-fluoro-α-D-[6-3H]glucopyranosyl uridine-5′-diphosphate

Robert V. Stick; Andrew G. Watts

doi:10.1071/CH02057

A direct synthesis of 2-deoxy-2-fluoro-α-D-[6-³H]glucopyranosyl uridine-5′-diphosphate

Robert V. Stick, Andrew G. Watts

The University of Western Australia

Research output: Contribution to journal › Article › peer-review

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Abstract

The synthesis of 2-deoxy-2-fluoro-α-D[6-³H]glucopyranosyl uridine-5′-diphosphate, with the late introduction of the radiolable, has been achieved from 3,4-di-O-benzyl-2-deoxy-2-fluoro-α-D-glucosyl diphenyl phosphate, by an oxidation-reduction sequence, followed by protecting group removal and morpholidate coupling to uridine-5′-monophosphate.

Original language	English
Pages (from-to)	327-329
Number of pages	3
Journal	Australian Journal of Chemistry
Volume	55
Issue number	5
DOIs	https://doi.org/10.1071/CH02057
Publication status	Published - 2 Aug 2002

ASJC Scopus subject areas

General Chemistry

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10.1071/CH02057

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abstract = "The synthesis of 2-deoxy-2-fluoro-α-D[6-3H]glucopyranosyl uridine-5′-diphosphate, with the late introduction of the radiolable, has been achieved from 3,4-di-O-benzyl-2-deoxy-2-fluoro-α-D-glucosyl diphenyl phosphate, by an oxidation-reduction sequence, followed by protecting group removal and morpholidate coupling to uridine-5′-monophosphate.",

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AB - The synthesis of 2-deoxy-2-fluoro-α-D[6-3H]glucopyranosyl uridine-5′-diphosphate, with the late introduction of the radiolable, has been achieved from 3,4-di-O-benzyl-2-deoxy-2-fluoro-α-D-glucosyl diphenyl phosphate, by an oxidation-reduction sequence, followed by protecting group removal and morpholidate coupling to uridine-5′-monophosphate.

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A direct synthesis of 2-deoxy-2-fluoro-α-D-[6-³H]glucopyranosyl uridine-5′-diphosphate

Abstract

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