A direct role for Sox10 in specification of neural crest-derived sensory neurons

Thomas J. Carney, Kirsten A. Dutton, Emma Greenhill, Mariana Delfino-Machin, Pascale Dufourcq, Patrick Blader, Robert N. Kelsh

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Abstract

sox10 is necessary for development of neural and pigment cell derivatives of the neural crest ( NC). However, whereas a direct role for Sox10 activity has been established in pigment and glial lineages, this is more controversial in NC-derived sensory neurons of the dorsal root ganglia (DRGs). We proposed that sox10 functioned in specification of sensory neurons, whereas others suggested that sensory neuronal defects were merely secondary to absence of glia. Here we provide evidence that in zebrafish, early DRG sensory neuron survival is independent of differentiated glia. Critically, we demonstrate that Sox10 is expressed transiently in the sensory neuron lineage, and species sensory neuron precursors by regulating the proneural gene neurogenin1. Consistent with this, we have isolated a novel sox10 mutant that lacks glia and yet displays a neurogenic DRG phenotype. In conjunction with previous findings, these data establish the generality of our model of Sox10 function in NC fate specification.
Original languageEnglish
Pages (from-to)4619-4630
JournalDevelopment
Volume133
Issue number23
DOIs
Publication statusPublished - 2006

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Neural Crest
Sensory Receptor Cells
Neuroglia
Spinal Ganglia
Zebrafish
Phenotype
Genes

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Carney, T. J., Dutton, K. A., Greenhill, E., Delfino-Machin, M., Dufourcq, P., Blader, P., & Kelsh, R. N. (2006). A direct role for Sox10 in specification of neural crest-derived sensory neurons. Development, 133(23), 4619-4630. https://doi.org/10.1242/dev.02668

A direct role for Sox10 in specification of neural crest-derived sensory neurons. / Carney, Thomas J.; Dutton, Kirsten A.; Greenhill, Emma; Delfino-Machin, Mariana; Dufourcq, Pascale; Blader, Patrick; Kelsh, Robert N.

In: Development, Vol. 133, No. 23, 2006, p. 4619-4630.

Research output: Contribution to journalArticle

Carney, TJ, Dutton, KA, Greenhill, E, Delfino-Machin, M, Dufourcq, P, Blader, P & Kelsh, RN 2006, 'A direct role for Sox10 in specification of neural crest-derived sensory neurons', Development, vol. 133, no. 23, pp. 4619-4630. https://doi.org/10.1242/dev.02668
Carney TJ, Dutton KA, Greenhill E, Delfino-Machin M, Dufourcq P, Blader P et al. A direct role for Sox10 in specification of neural crest-derived sensory neurons. Development. 2006;133(23):4619-4630. https://doi.org/10.1242/dev.02668
Carney, Thomas J. ; Dutton, Kirsten A. ; Greenhill, Emma ; Delfino-Machin, Mariana ; Dufourcq, Pascale ; Blader, Patrick ; Kelsh, Robert N. / A direct role for Sox10 in specification of neural crest-derived sensory neurons. In: Development. 2006 ; Vol. 133, No. 23. pp. 4619-4630.
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