A direct approach to a 6-hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5] tetrazine library

N.V. Palysaeva, Katerina Kumpan, M.I. Struchkova, I.L. Dalinger, A.V. Kormanov, N.S. Aleksandrova, V.M. Chernyshev, D.F. Pyreu, K.Y. Suponitsky, A.B. Sheremetev

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42 Citations (Scopus)

Abstract

The synthesis of 6-hetarylamino[1,2,4]triazolo[4,3-b]-[1,2,4,5]tetrazines is reported. The functionalized secondary amines were constructed via a K 2CO3-mediated SNAr reaction of weakly basic hetarylamines with 3-(3,5-dimethylpyrazol-1-yl)[1,2,4]triazolo[4,3-b]-[1,2,4,5]tetrazines, which allowed displacement 3,5-dimethylpyrazolyl leaving group. Significantly, the reaction exhibited a broad substrate scope and proceeded in good yields
Original languageEnglish
Pages (from-to)406-409
Number of pages4
JournalOrganic Letters
Volume16
Issue number2
DOIs
Publication statusPublished - 17 Jan 2014

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    Palysaeva, N. V., Kumpan, K., Struchkova, M. I., Dalinger, I. L., Kormanov, A. V., Aleksandrova, N. S., Chernyshev, V. M., Pyreu, D. F., Suponitsky, K. Y., & Sheremetev, A. B. (2014). A direct approach to a 6-hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5] tetrazine library. Organic Letters, 16(2), 406-409. https://doi.org/10.1021/ol403308h