TY - JOUR
T1 - A direct approach to a 6-hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5] tetrazine library
AU - Palysaeva, N.V.
AU - Kumpan, Katerina
AU - Struchkova, M.I.
AU - Dalinger, I.L.
AU - Kormanov, A.V.
AU - Aleksandrova, N.S.
AU - Chernyshev, V.M.
AU - Pyreu, D.F.
AU - Suponitsky, K.Y.
AU - Sheremetev, A.B.
PY - 2014/1/17
Y1 - 2014/1/17
N2 - The synthesis of 6-hetarylamino[1,2,4]triazolo[4,3-b]-[1,2,4,5]tetrazines is reported. The functionalized secondary amines were constructed via a K 2CO3-mediated SNAr reaction of weakly basic hetarylamines with 3-(3,5-dimethylpyrazol-1-yl)[1,2,4]triazolo[4,3-b]-[1,2,4,5]tetrazines, which allowed displacement 3,5-dimethylpyrazolyl leaving group. Significantly, the reaction exhibited a broad substrate scope and proceeded in good yields
AB - The synthesis of 6-hetarylamino[1,2,4]triazolo[4,3-b]-[1,2,4,5]tetrazines is reported. The functionalized secondary amines were constructed via a K 2CO3-mediated SNAr reaction of weakly basic hetarylamines with 3-(3,5-dimethylpyrazol-1-yl)[1,2,4]triazolo[4,3-b]-[1,2,4,5]tetrazines, which allowed displacement 3,5-dimethylpyrazolyl leaving group. Significantly, the reaction exhibited a broad substrate scope and proceeded in good yields
UR - http://www.scopus.com/inward/record.url?scp=84896799566&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1021/ol403308h
U2 - 10.1021/ol403308h
DO - 10.1021/ol403308h
M3 - Article
SN - 1523-7060
VL - 16
SP - 406
EP - 409
JO - Organic Letters
JF - Organic Letters
IS - 2
ER -