A Colorimetric Chemosensor Based on a Nozoe Azulene That Detects Fluoride in Aqueous/Alcoholic Media

Lloyd C. Murfin; Kirstie Chiang; George T. Williams; Catherine L. Lyall; A. Toby A. Jenkins; Jannis Wenk; Tony D. James; Simon E. Lewis

doi:10.3389/fchem.2020.00010

A Colorimetric Chemosensor Based on a Nozoe Azulene That Detects Fluoride in Aqueous/Alcoholic Media

Lloyd C. Murfin, Kirstie Chiang, George T. Williams, Catherine L. Lyall, A. Toby A. Jenkins, Jannis Wenk, Tony D. James, Simon E. Lewis

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

19 Citations (SciVal)

94 Downloads (Pure)

Abstract

Colorimetry is an advantageous method for detecting fluoride in drinking water in a resource-limited context, e. g., in parts of the developing world where excess fluoride intake leads to harmful health effects. Here we report a selective colorimetric chemosensor for fluoride that employs an azulene as the reporter motif and a pinacolborane as the receptor motif. The chemosensor, NAz-6-Bpin, is prepared using the Nozoe azulene synthesis, which allows for its rapid and low-cost synthesis. The chemosensor gives a visually observable response to fluoride both in pure organic solvent and also in water/alcohol binary solvent mixtures.

Original language	English
Article number	10
Journal	Frontiers in Chemistry
Volume	8
DOIs	https://doi.org/10.3389/fchem.2020.00010
Publication status	Published - 29 Jan 2020

Funding

NMR and MS facilities were provided through the Material and Chemical Characterization Facility (MC2) at the University of Bath. Funding. We thank the EPSRC for DTP Ph.D. funding to LM, and the EPSRC and Public Health England for funding to GW. The Royal Society is gratefully acknowledged for a Wolfson merit award to TJ.

Keywords

azulene
boron
colorimetric
fluoride
sensor
water sensing

ASJC Scopus subject areas

General Chemistry

Access to Document

10.3389/fchem.2020.00010Licence: CC BY

fchem-08-00010(3)Final published version, 1 MBLicence: CC BY

Cite this

@article{2f29b5129dd441c7acaca91562fa942e,

title = "A Colorimetric Chemosensor Based on a Nozoe Azulene That Detects Fluoride in Aqueous/Alcoholic Media",

abstract = "Colorimetry is an advantageous method for detecting fluoride in drinking water in a resource-limited context, e. g., in parts of the developing world where excess fluoride intake leads to harmful health effects. Here we report a selective colorimetric chemosensor for fluoride that employs an azulene as the reporter motif and a pinacolborane as the receptor motif. The chemosensor, NAz-6-Bpin, is prepared using the Nozoe azulene synthesis, which allows for its rapid and low-cost synthesis. The chemosensor gives a visually observable response to fluoride both in pure organic solvent and also in water/alcohol binary solvent mixtures.",

keywords = "azulene, boron, colorimetric, fluoride, sensor, water sensing",

author = "Murfin, {Lloyd C.} and Kirstie Chiang and Williams, {George T.} and Lyall, {Catherine L.} and Jenkins, {A. Toby A.} and Jannis Wenk and James, {Tony D.} and Lewis, {Simon E.}",

year = "2020",

month = jan,

day = "29",

doi = "10.3389/fchem.2020.00010",

language = "English",

volume = "8",

journal = "Frontiers in Chemistry",

issn = "2296-2646",

publisher = "Frontiers Media SA",

}

TY - JOUR

T1 - A Colorimetric Chemosensor Based on a Nozoe Azulene That Detects Fluoride in Aqueous/Alcoholic Media

AU - Murfin, Lloyd C.

AU - Chiang, Kirstie

AU - Williams, George T.

AU - Lyall, Catherine L.

AU - Jenkins, A. Toby A.

AU - Wenk, Jannis

AU - James, Tony D.

AU - Lewis, Simon E.

PY - 2020/1/29

Y1 - 2020/1/29

N2 - Colorimetry is an advantageous method for detecting fluoride in drinking water in a resource-limited context, e. g., in parts of the developing world where excess fluoride intake leads to harmful health effects. Here we report a selective colorimetric chemosensor for fluoride that employs an azulene as the reporter motif and a pinacolborane as the receptor motif. The chemosensor, NAz-6-Bpin, is prepared using the Nozoe azulene synthesis, which allows for its rapid and low-cost synthesis. The chemosensor gives a visually observable response to fluoride both in pure organic solvent and also in water/alcohol binary solvent mixtures.

AB - Colorimetry is an advantageous method for detecting fluoride in drinking water in a resource-limited context, e. g., in parts of the developing world where excess fluoride intake leads to harmful health effects. Here we report a selective colorimetric chemosensor for fluoride that employs an azulene as the reporter motif and a pinacolborane as the receptor motif. The chemosensor, NAz-6-Bpin, is prepared using the Nozoe azulene synthesis, which allows for its rapid and low-cost synthesis. The chemosensor gives a visually observable response to fluoride both in pure organic solvent and also in water/alcohol binary solvent mixtures.

KW - azulene

KW - boron

KW - colorimetric

KW - fluoride

KW - sensor

KW - water sensing

UR - http://www.scopus.com/inward/record.url?scp=85079499606&partnerID=8YFLogxK

U2 - 10.3389/fchem.2020.00010

DO - 10.3389/fchem.2020.00010

M3 - Article

AN - SCOPUS:85079499606

SN - 2296-2646

VL - 8

JO - Frontiers in Chemistry

JF - Frontiers in Chemistry

M1 - 10

ER -

A Colorimetric Chemosensor Based on a Nozoe Azulene That Detects Fluoride in Aqueous/Alcoholic Media

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

MC2-Mass Spectrometry (MS)

MC2- Nuclear Magnetic Resonance (NMR)

Cite this

A Colorimetric Chemosensor Based on a Nozoe Azulene That Detects Fluoride in Aqueous/Alcoholic Media

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Equipment

MC2-Mass Spectrometry (MS)

MC2- Nuclear Magnetic Resonance (NMR)

Cite this