A 6.5-Mb yeast artificial chromosome contig incorporating 33 DNA markers on the human X chromosome at Xq22

D. Vetrie, E. Kendall, A. Coffey, S. Hassock, J. Collins, C. Todd, H. Lehrach, M. Bobrow, D.R. Bentley, A. Harris

Research output: Contribution to journalArticle

Abstract

The Xq22 region of the human X chromosome contains genes for a number of inherited disorders. Sixty-nine yeast artificial chromosome clones have been isolated and assembled into a 6.5-Mb contig that contains 33 DNA markers localized to this region. This contig extends distally from DXS366 to beyond DXS87 and includes the genes involved in X-linked agammaglobulinemia (btk), Fabry disease (GLA), and Pelizaeus-Merzbacher disease (PLP). The order of markers in this contig is consistent with the known genetic and physical mapping information of Xq22. This cloned material provides a source from which to isolate other genes located in this part of the X chromosome.
Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalGenomics
Volume19
Issue number1
DOIs
Publication statusPublished - 19 Jan 1994

Fingerprint

Chromosomes, Human, X
Yeast Artificial Chromosomes
Genetic Markers
Pelizaeus-Merzbacher Disease
Physical Chromosome Mapping
Fabry Disease
X-Linked Genes
X Chromosome
Genes
Clone Cells

Keywords

  • DNA marker
  • article
  • chromosomal localization
  • chromosome Xq
  • Fabry disease
  • gene isolation
  • gene location
  • gene mapping
  • human
  • human cell
  • Pelizaeus Merzbacher disease
  • priority journal
  • X chromosome
  • X linked agammaglobulinemia
  • yeast artificial chromosome

Cite this

A 6.5-Mb yeast artificial chromosome contig incorporating 33 DNA markers on the human X chromosome at Xq22. / Vetrie, D.; Kendall, E.; Coffey, A.; Hassock, S.; Collins, J.; Todd, C.; Lehrach, H.; Bobrow, M.; Bentley, D.R.; Harris, A.

In: Genomics, Vol. 19, No. 1, 19.01.1994, p. 42-47.

Research output: Contribution to journalArticle

Vetrie, D, Kendall, E, Coffey, A, Hassock, S, Collins, J, Todd, C, Lehrach, H, Bobrow, M, Bentley, DR & Harris, A 1994, 'A 6.5-Mb yeast artificial chromosome contig incorporating 33 DNA markers on the human X chromosome at Xq22', Genomics, vol. 19, no. 1, pp. 42-47. https://doi.org/10.1006/geno.1994.1010
Vetrie, D. ; Kendall, E. ; Coffey, A. ; Hassock, S. ; Collins, J. ; Todd, C. ; Lehrach, H. ; Bobrow, M. ; Bentley, D.R. ; Harris, A. / A 6.5-Mb yeast artificial chromosome contig incorporating 33 DNA markers on the human X chromosome at Xq22. In: Genomics. 1994 ; Vol. 19, No. 1. pp. 42-47.
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