A 6.5-Mb yeast artificial chromosome contig incorporating 33 DNA markers on the human X chromosome at Xq22

D. Vetrie; E. Kendall; A. Coffey; S. Hassock; J. Collins; C. Todd; H. Lehrach; M. Bobrow; D.R. Bentley; A. Harris

doi:10.1006/geno.1994.1010

A 6.5-Mb yeast artificial chromosome contig incorporating 33 DNA markers on the human X chromosome at Xq22

D. Vetrie, E. Kendall, A. Coffey, S. Hassock, J. Collins, C. Todd, H. Lehrach, M. Bobrow, D.R. Bentley, A. Harris

Department of Life Sciences

Guy's and St. Thomas' Hospitals NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

Abstract

The Xq22 region of the human X chromosome contains genes for a number of inherited disorders. Sixty-nine yeast artificial chromosome clones have been isolated and assembled into a 6.5-Mb contig that contains 33 DNA markers localized to this region. This contig extends distally from DXS366 to beyond DXS87 and includes the genes involved in X-linked agammaglobulinemia (btk), Fabry disease (GLA), and Pelizaeus-Merzbacher disease (PLP). The order of markers in this contig is consistent with the known genetic and physical mapping information of Xq22. This cloned material provides a source from which to isolate other genes located in this part of the X chromosome.

Original language	English
Pages (from-to)	42-47
Number of pages	6
Journal	Genomics
Volume	19
Issue number	1
DOIs	https://doi.org/10.1006/geno.1994.1010
Publication status	Published - 19 Jan 1994

Keywords

DNA marker
article
chromosomal localization
chromosome Xq
Fabry disease
gene isolation
gene location
gene mapping
human
human cell
Pelizaeus Merzbacher disease
priority journal
X chromosome
X linked agammaglobulinemia
yeast artificial chromosome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1006/geno.1994.1010

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title = "A 6.5-Mb yeast artificial chromosome contig incorporating 33 DNA markers on the human X chromosome at Xq22",

abstract = "The Xq22 region of the human X chromosome contains genes for a number of inherited disorders. Sixty-nine yeast artificial chromosome clones have been isolated and assembled into a 6.5-Mb contig that contains 33 DNA markers localized to this region. This contig extends distally from DXS366 to beyond DXS87 and includes the genes involved in X-linked agammaglobulinemia (btk), Fabry disease (GLA), and Pelizaeus-Merzbacher disease (PLP). The order of markers in this contig is consistent with the known genetic and physical mapping information of Xq22. This cloned material provides a source from which to isolate other genes located in this part of the X chromosome.",

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author = "D. Vetrie and E. Kendall and A. Coffey and S. Hassock and J. Collins and C. Todd and H. Lehrach and M. Bobrow and D.R. Bentley and A. Harris",

year = "1994",

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doi = "10.1006/geno.1994.1010",

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AU - Vetrie, D.

AU - Kendall, E.

AU - Coffey, A.

AU - Hassock, S.

AU - Collins, J.

AU - Todd, C.

AU - Lehrach, H.

AU - Bobrow, M.

AU - Bentley, D.R.

AU - Harris, A.

PY - 1994/1/19

Y1 - 1994/1/19

N2 - The Xq22 region of the human X chromosome contains genes for a number of inherited disorders. Sixty-nine yeast artificial chromosome clones have been isolated and assembled into a 6.5-Mb contig that contains 33 DNA markers localized to this region. This contig extends distally from DXS366 to beyond DXS87 and includes the genes involved in X-linked agammaglobulinemia (btk), Fabry disease (GLA), and Pelizaeus-Merzbacher disease (PLP). The order of markers in this contig is consistent with the known genetic and physical mapping information of Xq22. This cloned material provides a source from which to isolate other genes located in this part of the X chromosome.

AB - The Xq22 region of the human X chromosome contains genes for a number of inherited disorders. Sixty-nine yeast artificial chromosome clones have been isolated and assembled into a 6.5-Mb contig that contains 33 DNA markers localized to this region. This contig extends distally from DXS366 to beyond DXS87 and includes the genes involved in X-linked agammaglobulinemia (btk), Fabry disease (GLA), and Pelizaeus-Merzbacher disease (PLP). The order of markers in this contig is consistent with the known genetic and physical mapping information of Xq22. This cloned material provides a source from which to isolate other genes located in this part of the X chromosome.

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KW - article

KW - chromosomal localization

KW - chromosome Xq

KW - Fabry disease

KW - gene isolation

KW - gene location

KW - gene mapping

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KW - human cell

KW - Pelizaeus Merzbacher disease

KW - priority journal

KW - X chromosome

KW - X linked agammaglobulinemia

KW - yeast artificial chromosome

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JO - Genomics

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A 6.5-Mb yeast artificial chromosome contig incorporating 33 DNA markers on the human X chromosome at Xq22

Abstract

Keywords

UN SDGs

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