A 6.5-Mb yeast artificial chromosome contig incorporating 33 DNA markers on the human X chromosome at Xq22

D. Vetrie, E. Kendall, A. Coffey, S. Hassock, J. Collins, C. Todd, H. Lehrach, M. Bobrow, D.R. Bentley, A. Harris

Research output: Contribution to journalArticle

Abstract

The Xq22 region of the human X chromosome contains genes for a number of inherited disorders. Sixty-nine yeast artificial chromosome clones have been isolated and assembled into a 6.5-Mb contig that contains 33 DNA markers localized to this region. This contig extends distally from DXS366 to beyond DXS87 and includes the genes involved in X-linked agammaglobulinemia (btk), Fabry disease (GLA), and Pelizaeus-Merzbacher disease (PLP). The order of markers in this contig is consistent with the known genetic and physical mapping information of Xq22. This cloned material provides a source from which to isolate other genes located in this part of the X chromosome.
Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalGenomics
Volume19
Issue number1
DOIs
Publication statusPublished - 19 Jan 1994

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Keywords

  • DNA marker
  • article
  • chromosomal localization
  • chromosome Xq
  • Fabry disease
  • gene isolation
  • gene location
  • gene mapping
  • human
  • human cell
  • Pelizaeus Merzbacher disease
  • priority journal
  • X chromosome
  • X linked agammaglobulinemia
  • yeast artificial chromosome

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