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2017

High-Throughput Screening to identify novel inhibitors of human α-methylacyl-CoA racemase 1A (AMACR; P504S)

Petrova, Y., Mattan, H., Lee, G. L., Jevglevskis, M., Woodman, T. & Lloyd, M., 21 Apr 2017.

Research output: Contribution to conferencePoster

File
27 Downloads (Pure)
2018

Long-wavelength TCF-based fluorescence probes for the detection and intracellular imaging of biological thiols

Sedgwick, A. C., Gardiner, J. E., Kim, G., Yevglevskis, M., Lloyd, M. D., Jenkins, A. T. A., Bull, S. D., Yoon, J. & James, T. D., 11 May 2018, In : Chemical Communications. 54, 38, p. 4786-4789 4 p.

Research output: Contribution to journalArticle

Open Access
26 Citations (Scopus)
2015

New routes to fight castrate-resistant prostate cancer: targeting α-methylacyl-CoA racemase (AMACR)

Lee, G. L., Jevglevskis, M., Threadgill, M., Woodman, T. & Lloyd, M., 2015.

Research output: Contribution to conferencePoster

New routes to fight castrate-resistant prostate cancer: targeting α-methylacyl-CoA racemase (AMACR)

Lee, G. L., Jevglevskis, M., Threadgill, M., Woodman, T. & Lloyd, M., 2015, (Unpublished).

Research output: Contribution to conferencePoster

2005

Crystal structure of human carbonic anhydrase II at 1.95 Å resolution in complex with 667-coumate, a novel anti-cancer agent

Lloyd, M. D., Pederick, R. L., Natesh, R., Woo, L. W. L., Purohit, A., Reed, M. J., Acharya, R. & Potter, B. V. L., 2005, In : Biochemical Journal. 385, Pt 3, p. 715-720

Research output: Contribution to journalArticle

42 Citations (Scopus)
2004

Controlling the substrate selectivity of deacetoxy/deacetylcephalosporin C synthase

Lloyd, M. D., Lipscomb, S. J., Hewitson, K. S., Hensgens, C. M. H., Baldwin, J. E. & Schofield, C. J., 2004, In : Journal of Biological Chemistry. 279, 15, p. 15420-15426 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2007

Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target

Darley, D. J., Butler, D. S., Threadgill, M. D. & Lloyd, M. D., Nov 2007.

Research output: Contribution to conferenceOther

2008

Synthesis of a mimic of phosphorserylproline as a potential inhibitor of Pin1

Beauchard, A., Phillips, V. A., Lloyd, M. D. & Threadgill, M. D., Mar 2008.

Research output: Contribution to conferenceOther

1998

Structure of a cephalosporin synthase

Valegård, K., Van Scheltinga, A. C. T., Lloyd, M. D., Hara, T., Ramaswamy, S., Perrakis, A., Thompson, A., Lee, H-J., Baldwin, J. E., Schofield, C. J., Hajdu, J. & Andersson, I., 20 Aug 1998, In : Nature. 394, 6695, p. 805-809

Research output: Contribution to journalArticle

295 Citations (Scopus)
2002

Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal α oxidation of phytanic acid

Mukherji, M., Kershaw, N. J., Schofield, C. J., Wierzbicki, A. S. & Lloyd, M. D., 2002, In : Chemistry & Biology. 9, p. 597-605 9 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2003

The kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase

Lee, H. J., Dai, Y. F., Shiau, C. Y., Schofield, C. J. & Lloyd, M. D., 2003, In : European Journal of Biochemistry. 270, p. 1301-1307 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2020

Professor Sir Jack E. Baldwin, FRS

Lloyd, M., Apr 2020, The Biochemist, 42, 2, p. 1 1 p.

Research output: Contribution to specialist publicationLetter

Open Access
2011

Uncertainty in pricing decisions in competitive bidding for service contracts

Kreye, M., Newnes, L. & Goh, Y. M., Aug 2011.

Research output: Contribution to conferencePoster

File
32 Downloads (Pure)
2010

Information display for decisions under uncertainty

Kreye, M. E., Goh, Y. M. & Newnes, L. B., 2010.

Research output: Contribution to conferencePaper

1 Citation (Scopus)
2008

Characterising the information content of an email corpus from a software design project

Wasiak, J., Hicks, B., Newnes, L. & Dong, A., Apr 2008.

Research output: Contribution to conferencePaper

Through life costing in electronic defence systems: an integrated data-driven multi-level approach

Cheung, W., Newnes, L., Mileham, A. R., Marsh, R. & Lanham, J., 2008, Proceedings of the 38th International Conference on Computers and Industrial Engineering. Xia, G. P. & Deng, X. Q. (eds.). China: Publishing House Electronics Industry, Vol. 1-3. p. 2119-2128 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2007

Estimation of non-recurring costs in manufacturing

Bradbery, R., Newnes, L. B. & Mileham, A. R., Sep 2007.

Research output: Contribution to conferencePaper

A study of life cycle costing in the perspectives of research and commercial applications in the 21st century

Cheung, W. M., Newnes, L. B., Mileham, A. R., Marsh, R. & Lanham, J. D., 2007.

Research output: Contribution to conferencePaper

Modelling an assembly process using a close coupled generative cost model and a discrete event simulation

Marsh, R., Cheung, W. M., Lanham, J. D., Newnes, L. B. & Mileham, A. R., 2007, p. 339-348. 10 p.

Research output: Contribution to conferencePaper

A generic model for creativity and innovation: overview for early phases of engineering design

Pahl, A. K., Newnes, L. B. & McMahon, C. A., 2007, In : Journal of Design Research. 6, 1-2, p. 5-44 40 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2000

Ten stages to optimising electronic manufacturing

Newnes, L. B., Mileham, A. R. & Doniavi, A., 2000, p. 521-530. 10 p.

Research output: Contribution to conferencePaper

1999

Moving to right first time through the application of forging simulation - an industrial case study

Crookes, J. M., Mynors, D. J., Bramley, A. N., Garner, D. G., Hankers, J. B., Haseldine, J., Delday, T. D., Mileham, A. R., Newnes, L. B., Owen, G. W., Mileham, A. R. (ed.), Newnes, L. B. (ed.) & Owen, G. W. (ed.), 1999, p. 99-103. 5 p.

Research output: Contribution to conferencePaper

Die design for the cold forging of spur gears

Kwon, H. H., Bramley, A. N., Mileham, A. R., Newnes, L. B. & Owen, G. W., 1999, p. 105-109. 5 p.

Research output: Contribution to conferencePaper

3 Citations (Scopus)

The use of computational fluid dynamics in the design of a pharmaceutical processor

MacGregor, S. A., Newnes, L. B., Li, M., Staniforth, J. N., Tobyn, M. J., Kay, G. R., Horrill, M. D., Lamming, R. C. & Hajee, D. W., 1999.

Research output: Contribution to conferencePaper

1997

Systems modelling methodologies in the manufacturing environment

Doniavi, A., Mileham, A. R. & Newnes, L. B., Aug 1997, p. 373-378. 6 p.

Research output: Contribution to conferencePaper

2011

An analysis of industrial practice for estimating the in-service costs of a product service system

Huang, X., Newnes, L. & Parry, G., 2011, Proceedings of the ASME Design Engineering Technical Conference. ASME, Vol. 6. p. 605-615 11 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Modeling uncertainty in through-life costing at the early design stages-I

Saravi, M., Goh, Y. M., Newnes, L. B., Mileham, A. R., Morton, K. & Beedall, D., 2011, ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference: Volume 9: 23rd International Conference on Design Theory and Methodology; 16th Design for Manufacturing and the Life Cycle Conference. New York, U. S. A.: ASME, p. 1033-1042 10 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)
2016

Balancing global customer needs and profitability using a novel business model for new model programmes in the automotive industry

Mills, R., Newnes, L. B. & Nassehi, A., 1 Sep 2016, In : Procedia CIRP. 52, p. 56-61 6 p.

Research output: Contribution to journalArticle

Open Access
2020

Scientific, sustainability and regulatory challenges of cultured meat

Post, M., Levenberg, S., Kaplan, D., Genovese, N., Fu, J., Bryant, C., Negowetti, N., Verzijden, K. & Moutsatsou, P., 31 Jul 2020, In : Nature Food. 1, 7, p. 403-415 13 p.

Research output: Contribution to journalReview article

2001

A systems approach to semiconductor optimisation

Newnes, L. B., Mileham, A. R. & Doniavi, A., 2001, In : IEEE Transactions on Electronic Packaging Manufacturing. 24, 3, p. 171-177 7 p.

Research output: Contribution to journalArticle

2012

Cost engineering for manufacturing: Current and future research

Xu, Y., Elgh, F., Erkoyuncu, J. A., Bankole, O., Goh, Y., Cheung, W. M., Baguley, P., Wang, Q., Arundachawat, P., Shehab, E., Newnes, L. & Roy, R., 2012, In : International Journal of Computer Integrated Manufacturing. 25, 4-5, p. 300-314 15 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2011

Uncertainty analysis and its application to service contracts

Kreye, M., Newnes, L. & Goh, Y-M., Aug 2011, p. 1-12. 12 p.

Research output: Contribution to conferencePaper

3 Citations (Scopus)
2009

Engineering work and email: an analysis of the information content of email in a major systems engineering project

Wasiak, J., Hicks, B., Dong, A. & Newnes, L., Aug 2009, Proceedings of the ASME International Design Engineering Technical Conferences and Computers and Information in Engineering Conference 2009, DETC 2009. New York, U. S. A.: ASME, Vol. 8. p. 915-925 11 p. DETC2009-86832

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)
1996

Powder processing from the 1980's to the 1990's

Newnes, L. B., MacGregor, S. A., Staniforth, J. N., Kay, G. R., Marinescu, I. D. & Marinescu, I. D. (ed.), Jul 1996, p. 287-289. 3 p.

Research output: Contribution to conferencePaper

2012

The adaptation of product cost estimation techniques to estimate the cost of service

Huang, X. X., Newnes, L. B. & Parry, G. C., 2012, In : International Journal of Computer Integrated Manufacturing. 25, 4-5, p. 417-431 15 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Special issue on through life cost estimating

Newnes, L. & Valerdi, R., 2012, In : International Journal of Computer Integrated Manufacturing. 25, 4-5, p. 297-299 3 p.

Research output: Contribution to journalArticle

2016

Life cycle decision support tools: The use of quality management techniques in combating decision tool 'performance decay'

Lattanzio, S., Newnes, L., McManus, M. & Dunkley, D., 1 Jan 2016, 21st Design for Manufacturing and the Life Cycle Conference: 10th International Conference on Micro- and Nanosystems. U. S. A.: American Society of Mechanical Engineers (ASME), Vol. 4. p. V004Y05A034 DETC2016-59888

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2011

Data-driven through-life costing to support product lifecycle management solutions in innovative product development

Cheung, W. M., Mileham, A. R., Newnes, L. B., Marsh, R. & Lanham, J. D., 1 Oct 2011, In : International Journal of Product Lifecycle Management. 5, 2-4, p. 122-142 21 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2015

Addressing uncertainty in estimating the cost for a product-service-system delivering availability: epistemology and ontology

Goh, Y. M., Newnes, L., Settanni, E., Thenent, N. & Parry, G., 2015, Ontology Modeling in Physical Asset Integrity Management: Addressing Uncertainty in Estimating the Cost for a Product-Service-System Delivering Availability: Epistemology and Ontology. Ibrahimipour, V. & Yacout, S. (eds.). London, U. K.: Springer, p. 199-220 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)
1999

The application of computational fluid dynamics to the development of a pharmaceutical processor

MacGregor, S. A., Newnes, L. B., Li, M., Staniforth, J. N., Tobyn, M. J., Kay, G. R., Horrill, M. D., Lamming, R. C., Hajee, D. W., Wong, D., Chippendale, K. E. & Page, T., 1999, In : Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture. 213, 7, p. 737-740 4 p.

Research output: Contribution to journalArticle

1998

The use of computational fluid dynamics in the design of a pharmaceutical processor

MacGregor, S. A., Newnes, L. B., Li, M., Atherton, G., Staniforth, J. N., Tobyn, M. J., Kay, G. R., Horrill, M., Lamming, R. C. & Hajee, D., 1 Dec 1998, In : ASME Publications - Pvp. 377-372, p. 17-25 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2007

Modelling randomness of a manual assembly system with walking workers

Wang, Q., Pan, L., Mileham, A. R., Owen, G. W., Newnes, L. B. & Chatwin, C. R., Feb 2007, In : International Journal of Industrial and Systems Engineering. 2, 2, p. 195-210 16 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2011
6 Citations (Scopus)

Analysing the use of four creativity tools in a constrained design situation

Snider, C., Dekoninck, E., Yue, H. & Howard, T., Aug 2011.

Research output: Contribution to conferencePaper

2010

Understanding the rapid evaluation of innovative ideas in the early stages of design

Ferioli, M., Dekoninck, E. A., Culley, S., Roussel, B. & Renaud, J., 2010, In : International Journal of Product Development. 12, 1, p. 67-83 17 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2009

Quantifying the Energy Impacts of Use: A Product Energy Profile Approach

Elias, E., Dekoninck, E. & Culley, S., 4 May 2009.

Research output: Contribution to conferencePaper

File
49 Downloads (Pure)
2018

Formal system for the expression of target-oriented design heuristics

Bonvoisin, J., Buchert, T. & Stark, R., 2018, 15th International Design Conference, DESIGN 2018. Bojcetic, N., Pavkovic, N., Marjanovic, D., Storga, M. & Skec, S. (eds.). Design Society, Vol. 1. p. 45 - 56 12 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
File
34 Downloads (Pure)
2007

An empirical study of how innovation and the environment are considered in current engineering design practise

O'Hare, J., Dekoninck, E., Liang, H. & Turnbull, A., Jun 2007, Advances in Life Cycle Engineering for Sustainable Manufacturing Businesses - Proceedings of the 14th CIRP Conference on Life Cycle Engineering. New York: Springer, p. 213-218 6 p. (Advances in Life Cycle Engineering for Sustainable Manufacturing Businesses - Proceedings of the 14th CIRP Conference on Life Cycle Engineering).

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)
2006

Information as an Input into the creative process

Howard, T. J., Culley, S. J. & Dekoninck, E., 2006, p. 549-556. 8 p.

Research output: Contribution to conferencePaper

17 Citations (Scopus)