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2019
4 Citations (Scopus)

Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR

Kühn, F. J. P., Watt, J. M., Potter, B. V. L. & Lückhoff, A., 21 Mar 2019, In : Scientific Reports. 9, 1, p. 1-12 12 p., 4985.

Research output: Contribution to journalArticle

Open Access

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5'-diphosphate ribose (ADPR)

Potter, B., Watt, J. M. & Baszczynski, O., 16 Dec 2019, (Accepted/In press) In : RSC Advances.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2

Potter, B., Watt, J. M. & Baszczynski, O., 17 May 2019, In : Journal of Organic Chemistry. 84, 10, p. 6143-6157 15 p.

Research output: Contribution to journalArticle

2018
1 Citation (Scopus)
16 Downloads (Pure)

A Fluorescent Probe Identifies Active Site Ligands of Inositol Pentakisphosphate 2-Kinase

Potter, B. & Godage, H., 11 Oct 2018, In : Journal of Medicinal Chemistry. 61, 19, p. 8838-8846 9 p.

Research output: Contribution to journalArticle

Open Access
File
Inositol Phosphates
Fluorescent Dyes
Catalytic Domain
Ligands
Phosphotransferases

Quinazolinone-based Anticancer Agents: Synthesis, Anti-proliferative SAR, Anti-tubulin Activity and Tubulin Co-crystal Structure

Dohle, W., Jourdan, F., Menchon, G., Prota, A., Foster, P. A., Mannion, P., Hamel, E., Thomas, M., Kasprzyk, P. G., Ferrandis, E., Steinmetz, M. O., Leese, M. & Potter, B., 2018, (Unpublished) In : Journal of Medicinal Chemistry. 49 p.

Research output: Contribution to journalArticle

Quinazolinones
Tubulin
Steryl-Sulfatase
Antineoplastic Agents
Colchicine
2 Citations (Scopus)

Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease

Zhang, B., Watt, J. M., Cordiglieri, C., Dammermann, W., Mahon, M., Flugel, A., Guse, A. H. & Potter, B., 13 Nov 2018, In : Scientific Reports. 8, 17 p., 16775.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Steroid sulphatase inhibition via aryl sulphamates: Clinical progress, mechanism and future prospects

Potter, B. V. L., 1 Aug 2018, In : Journal of Molecular Endocrinology. 61, 2, p. T233-T252 20 p.

Research output: Contribution to journalReview article

Open Access

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers

Watt, J. M., Thomas, M. & Potter, B., 15 Oct 2018, In : Scientific Reports. 8, 15268.

Research output: Contribution to journalArticle

Open Access
Ribose
Diphosphates
Adenosine
Cyclization
Adenine
2017
20 Citations (Scopus)
123 Downloads (Pure)

2ʹ-Deoxyadenosine 5ʹ-diphosphoribose is an endogenous TRPM2 superagonist

Fliegert, R., Bauche, A., Wolf Pérez, A-M., Watt, J. M., Rozewitz, M. D., Winzer, R., Janus, M., Gu, F., Rosche, A., Harneit, A., Flato, M., Moreau, C., Kirchberger, T., Wolters, V., Potter, B. V. L. & Guse, A. H., 1 Sep 2017, In : Nature Chemical Biology. 13, p. 1036-1044 9 p.

Research output: Contribution to journalArticle

Open Access
File
Nicotinamide-Nucleotide Adenylyltransferase
Nicotinamide Mononucleotide
Adenosine Diphosphate Ribose
Glycoside Hydrolases
NAD
2 Citations (Scopus)
Open Access
Tetrahydroisoquinolines
Cyclization
Alkylation
Alkaloids
Minerals
11 Citations (Scopus)

Ligand induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg 1433 and Tyr 1349

Fliegert, R., Watt, J. M., Schöbel, A., Rozewitz, M. D., Moreau, C., Kirchberger, T., Thomas, M. P., Sick, W., Araujo, A. C., Harneit, A., Potter, B. V. L. & Guse, A. H., 16 Jun 2017, In : Biochemical Journal. 474, 13, p. 2159-2175 BCJ20170091.

Research output: Contribution to journalArticle

Open Access
Adenosine Diphosphate Ribose
Ribose
Chemical activation
Ligands
Hydrogen Bonding
1 Citation (Scopus)
28 Downloads (Pure)

Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5'-diphosphate ribose”

Watt, J. M., Graeff, R., Thomas, M. P. & Potter, B., 23 Nov 2017, In : Scientific Reports. 7, 16100.

Research output: Contribution to journalArticle

Open Access
File
Inosine
Ribose
Diphosphates
Second Messenger Systems
Substrates
11 Citations (Scopus)
191 Downloads (Pure)

SHIP2: structure, function and inhibition

Thomas, M. P., Erneux, C. & Potter, B. V. L., 1 Feb 2017, In : ChemBiochem. 18, 3, p. 233-247

Research output: Contribution to journalArticle

Open Access
File
Inositol Phosphates
Immune system
Bone Development
Phosphatidylinositols
Endocytosis
2 Citations (Scopus)

Simple synthesis of 32P-labelled inositol hexakisphosphates for study of phosphate transformations

Whitfield, H., Riley, A. M., Diogenous, S., Godage, H. Y., Potter, B. & Brearley, C. A., 27 Jun 2017, In : Plant and Soil.

Research output: Contribution to journalArticle

Open Access
inositol phosphates
phosphate
phosphates
synthesis
high performance liquid chromatography
2016
12 Citations (Scopus)
64 Downloads (Pure)

A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion

Raimondi, C., Calleja, V., Ferro, R., Fantin, A., Riley, A. M., Potter, B. V. L., Brennan, C. H., Maffucci, T., Larijani, B. & Falasca, M., 20 May 2016, In : Scientific Reports. 6, 26142.

Research output: Contribution to journalArticle

Open Access
File
Phospholipases
Phosphatidylinositols
Protein Kinases
Melanoma
Breast Neoplasms
5 Citations (Scopus)
100 Downloads (Pure)

Crystal structures of type-II inositol polyphosphate 5-phosphatase INPP5B with synthetic inositol polyphosphate surrogates reveal new mechanistic insights for the inositol 5-phosphatase family

Mills, S. J., Silvander, C., Cozier, G., Trésaugues, L., Nordlund, P. & Potter, B. V. L., 8 Mar 2016, In : Biochemistry. 55, 9, p. 1384-1397

Research output: Contribution to journalArticle

Open Access
File
Polyphosphates
Inositol
Phosphoric Monoester Hydrolases
Crystal structure
Phosphates
58 Citations (Scopus)
88 Downloads (Pure)

Insights into the activation mechanism of class I HDAC complexes by inositol phosphates

Watson, P. J., Millard, C. J., Riley, A. M., Robertson, N. S., Wright, L. C., Godage, H. Y., Cowley, S. M., Jamieson, A. G., Potter, B. V. L. & Schwabe, J. W. R., 25 Apr 2016, In : Nature Communications. 7, 11262.

Research output: Contribution to journalArticle

Open Access
File
inositols
Histone Deacetylases
Inositol Phosphates
phosphates
Chemical activation
48 Citations (Scopus)

The "other" inositols and their phosphates: synthesis, biology, and medicine (with recent advances in myo-inositol chemistry)

Thomas, M. P., Mills, S. J. & Potter, B. V. L., 26 Jan 2016, In : Angewandte Chemie-International Edition. 55, 5, p. 1614-1650

Research output: Contribution to journalArticle

Inositol Phosphates
Inositol
Medicine
Phytic Acid
Stereoisomerism
2015
92 Downloads (Pure)

Calcium Signalling Triggered by NAADP in T Cells Determines Cell Shape and Motility During Immune Synapse Formation

Nebel, M., Zhang, B., Odoardi, F., Flugel, A., Potter, B. & Guse, A. H., 2015, In : Messenger. 4, 1, p. 104-111

Research output: Contribution to journalArticle

Open Access
File
98 Downloads (Pure)

Design, Synthesis, and Chemical and Biological Properties of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose

Tsuzuki, T., Takano, S., Sakaguchi, N., Kudoh, T., Murayama, T., Sakurai, T., Higashida, H., Weber, K., Guse, A. H., Kameda, T., Hirokawa, T., Kumaki, Y., Arisawa, M., Potter, B. & Shuto, S., Jun 2015, In : Messenger. 3, 1-2, p. 35-51 17 p.

Research output: Contribution to journalArticle

Open Access
File
Cyclic ADP-Ribose
Adenosine Diphosphate
T-cells
Second Messenger Systems
Biological systems
3 Citations (Scopus)
86 Downloads (Pure)

Designer small molecules to target calcium signalling

Swarbrick, J., Riley, A., Mills, S. & Potter, B., 2015.

Research output: Contribution to conferencePaper

File
3 Citations (Scopus)

Designer small molecules to target calcium signalling

Swarbrick, J. M., Riley, A. M., Mills, S. J. & Potter, B. V. L., 1 Jun 2015, In : Biochemical Society Transactions. 43, 3, p. 417-425 9 p.

Research output: Contribution to journalArticle

Adenosine Diphosphate Ribose
Calcium Signaling
Calcium
Molecules
Inositol 1,4,5-Trisphosphate Receptors
29 Citations (Scopus)

Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Womens Health

Thomas, M. P. & Potter, B. V. L., 8 Oct 2015, In : Journal of Medicinal Chemistry. 58, 19, p. 7634-7658 25 p.

Research output: Contribution to journalReview article

22 Citations (Scopus)

Estrogen O-sulfamates and their analogues: clinical steroid sulfatase inhibitors with broad potential

Thomas, M. P. & Potter, B. V. L., 1 Sep 2015, In : Journal of Steroid Biochemistry and Molecular Biology. 153, p. 160-169 10 p., 4391.

Research output: Contribution to journalArticle

Steryl-Sulfatase
Estrogens
Derivatives
Prostatic Neoplasms
Hormones
10 Citations (Scopus)

In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer

Stengel, C., Newman, S. P., Day, J. M., Chander, S. K., Jourdan, F. L., Leese, M. P., Ferrandis, E., Regis-lydi, S., Potter, B. V. L., Reed, M. J., Purohit, A. & Foster, P. A., 15 Jul 2015, In : British Journal of Cancer. 111, 2, p. 300-308

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Paclitaxel
Tubulin
Heterografts
9 Citations (Scopus)
81 Downloads (Pure)

Synthetic tools for studying the chemical biology of InsP8

Riley, A. M., Wang, H., Shears, S. B. & Potter, B. V. L., 14 Aug 2015, In : Chemical Communications. 51, 63, p. 12605-12608 4 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphonoacetic Acid
Metabolism
Phosphates
Enzymes
Molecules
6 Citations (Scopus)

Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol

Shen, Y. C., Upadhyayula, R., Cevallos, S., Messick, R. J., Hsia, T., Leese, M. P., Jewett, D. M., Ferrer-Torres, D., Roth, T. M., Dohle, W., Potter, B. V. L. & Barald, K. F., 20 Oct 2015, In : British Journal of Cancer. 113, 8, p. 1158-1167 10 p.

Research output: Contribution to journalArticle

Hormones
Neurilemmoma
Tumor Cell Line
Neoplasms
Tumor Burden

The in vitro and in vivo activity of the microtubule disruptor STX140 is mediated by Hif-1 alpha and CAIX expression

Stengel, C., Newman, S. P., Leese, M. P., Thomas, M. P., Potter, B. V. L., Reed, M. J., Purohit, A. & Foster, P. A., 1 Oct 2015, In : Anticancer Research. 35, 10, p. 5249-5262 14 p.

Research output: Contribution to journalArticle

Microtubules
Phosphoglycerate Kinase
Genes
Messenger RNA
Facilitative Glucose Transport Proteins