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Author

  • Barry Potter
2020

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5'-diphosphate ribose (ADPR)

Potter, B., Watt, J. M. & Baszczynski, O., 2020, In : RSC Advances. 10, 3, p. 1776-1785

Research output: Contribution to journalArticle

Open Access

THERAPEUTICS USE OF PYRIDINIUM COMPOUNDS TO MODULATE NAADP ACTIVITY

Dowden, J., Galione, A. & Potter, B., 2020, IPC No. A61K31/4425; A61K31/4439; A61K45/06; C07D213/20; C07D213/80; C07D495/04;, Patent No. WO2005054198A3, 6 Dec 2004, Priority date 5 Dec 2003, Priority No. 0328134.0

Research output: Patent

2019

Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR

Kühn, F. J. P., Watt, J. M., Potter, B. V. L. & Lückhoff, A., 21 Mar 2019, In : Scientific Reports. 9, 1, p. 1-12 12 p., 4985.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2

Potter, B., Watt, J. M. & Baszczynski, O., 17 May 2019, In : Journal of Organic Chemistry. 84, 10, p. 6143-6157 15 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
10 Downloads (Pure)
2018

A Fluorescent Probe Identifies Active Site Ligands of Inositol Pentakisphosphate 2-Kinase

Potter, B. & Godage, H., 11 Oct 2018, In : Journal of Medicinal Chemistry. 61, 19, p. 8838-8846 9 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
30 Downloads (Pure)

Quinazolinone-based Anticancer Agents: Synthesis, Anti-proliferative SAR, Anti-tubulin Activity and Tubulin Co-crystal Structure

Dohle, W., Jourdan, F., Menchon, G., Prota, A., Foster, P. A., Mannion, P., Hamel, E., Thomas, M., Kasprzyk, P. G., Ferrandis, E., Steinmetz, M. O., Leese, M. & Potter, B., 2018, (Unpublished) In : Journal of Medicinal Chemistry. 49 p.

Research output: Contribution to journalArticle

Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease

Zhang, B., Watt, J. M., Cordiglieri, C., Dammermann, W., Mahon, M., Flugel, A., Guse, A. H. & Potter, B., 13 Nov 2018, In : Scientific Reports. 8, 17 p., 16775.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Steroid sulphatase inhibition via aryl sulphamates: Clinical progress, mechanism and future prospects

Potter, B. V. L., 1 Aug 2018, In : Journal of Molecular Endocrinology. 61, 2, p. T233-T252 20 p.

Research output: Contribution to journalReview article

Open Access
19 Citations (Scopus)

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers

Watt, J. M., Thomas, M. & Potter, B., 15 Oct 2018, In : Scientific Reports. 8, 15268.

Research output: Contribution to journalArticle

Open Access
2017

2ʹ-Deoxyadenosine 5ʹ-diphosphoribose is an endogenous TRPM2 superagonist

Fliegert, R., Bauche, A., Wolf Pérez, A-M., Watt, J. M., Rozewitz, M. D., Winzer, R., Janus, M., Gu, F., Rosche, A., Harneit, A., Flato, M., Moreau, C., Kirchberger, T., Wolters, V., Potter, B. V. L. & Guse, A. H., 1 Sep 2017, In : Nature Chemical Biology. 13, p. 1036-1044 9 p.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
152 Downloads (Pure)
Open Access
3 Citations (Scopus)

Ligand induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg 1433 and Tyr 1349

Fliegert, R., Watt, J. M., Schöbel, A., Rozewitz, M. D., Moreau, C., Kirchberger, T., Thomas, M. P., Sick, W., Araujo, A. C., Harneit, A., Potter, B. V. L. & Guse, A. H., 16 Jun 2017, In : Biochemical Journal. 474, 13, p. 2159-2175 BCJ20170091.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5'-diphosphate ribose”

Watt, J. M., Graeff, R., Thomas, M. P. & Potter, B., 23 Nov 2017, In : Scientific Reports. 7, 16100.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
35 Downloads (Pure)

SHIP2: structure, function and inhibition

Thomas, M. P., Erneux, C. & Potter, B. V. L., 1 Feb 2017, In : ChemBiochem. 18, 3, p. 233-247

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
258 Downloads (Pure)

Simple synthesis of 32P-labelled inositol hexakisphosphates for study of phosphate transformations

Whitfield, H., Riley, A. M., Diogenous, S., Godage, H. Y., Potter, B. & Brearley, C. A., 27 Jun 2017, In : Plant and Soil.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2016

A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion

Raimondi, C., Calleja, V., Ferro, R., Fantin, A., Riley, A. M., Potter, B. V. L., Brennan, C. H., Maffucci, T., Larijani, B. & Falasca, M., 20 May 2016, In : Scientific Reports. 6, 26142.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
84 Downloads (Pure)

Crystal structures of type-II inositol polyphosphate 5-phosphatase INPP5B with synthetic inositol polyphosphate surrogates reveal new mechanistic insights for the inositol 5-phosphatase family

Mills, S. J., Silvander, C., Cozier, G., Trésaugues, L., Nordlund, P. & Potter, B. V. L., 8 Mar 2016, In : Biochemistry. 55, 9, p. 1384-1397

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
128 Downloads (Pure)

Insights into the activation mechanism of class I HDAC complexes by inositol phosphates

Watson, P. J., Millard, C. J., Riley, A. M., Robertson, N. S., Wright, L. C., Godage, H. Y., Cowley, S. M., Jamieson, A. G., Potter, B. V. L. & Schwabe, J. W. R., 25 Apr 2016, In : Nature Communications. 7, 11262.

Research output: Contribution to journalArticle

Open Access
File
71 Citations (Scopus)
114 Downloads (Pure)

The "other" inositols and their phosphates: synthesis, biology, and medicine (with recent advances in myo-inositol chemistry)

Thomas, M. P., Mills, S. J. & Potter, B. V. L., 26 Jan 2016, In : Angewandte Chemie-International Edition. 55, 5, p. 1614-1650

Research output: Contribution to journalArticle

57 Citations (Scopus)
2015

Calcium Signalling Triggered by NAADP in T Cells Determines Cell Shape and Motility During Immune Synapse Formation

Nebel, M., Zhang, B., Odoardi, F., Flugel, A., Potter, B. & Guse, A. H., 2015, In : Messenger. 4, 1, p. 104-111

Research output: Contribution to journalArticle

Open Access
File
119 Downloads (Pure)

Design, Synthesis, and Chemical and Biological Properties of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose

Tsuzuki, T., Takano, S., Sakaguchi, N., Kudoh, T., Murayama, T., Sakurai, T., Higashida, H., Weber, K., Guse, A. H., Kameda, T., Hirokawa, T., Kumaki, Y., Arisawa, M., Potter, B. & Shuto, S., Jun 2015, In : Messenger. 3, 1-2, p. 35-51 17 p.

Research output: Contribution to journalArticle

Open Access
File
128 Downloads (Pure)

Designer small molecules to target calcium signalling

Swarbrick, J. M., Riley, A. M., Mills, S. J. & Potter, B. V. L., 1 Jun 2015, In : Biochemical Society Transactions. 43, 3, p. 417-425 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Designer small molecules to target calcium signalling

Swarbrick, J., Riley, A., Mills, S. & Potter, B., 2015.

Research output: Contribution to conferencePaper

File
4 Citations (Scopus)
118 Downloads (Pure)

Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Womens Health

Thomas, M. P. & Potter, B. V. L., 8 Oct 2015, In : Journal of Medicinal Chemistry. 58, 19, p. 7634-7658 25 p.

Research output: Contribution to journalReview article

36 Citations (Scopus)

Estrogen O-sulfamates and their analogues: clinical steroid sulfatase inhibitors with broad potential

Thomas, M. P. & Potter, B. V. L., 1 Sep 2015, In : Journal of Steroid Biochemistry and Molecular Biology. 153, p. 160-169 10 p., 4391.

Research output: Contribution to journalArticle

26 Citations (Scopus)

In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer

Stengel, C., Newman, S. P., Day, J. M., Chander, S. K., Jourdan, F. L., Leese, M. P., Ferrandis, E., Regis-lydi, S., Potter, B. V. L., Reed, M. J., Purohit, A. & Foster, P. A., 15 Jul 2015, In : British Journal of Cancer. 111, 2, p. 300-308

Research output: Contribution to journalArticle

10 Citations (Scopus)

Synthetic tools for studying the chemical biology of InsP8

Riley, A. M., Wang, H., Shears, S. B. & Potter, B. V. L., 14 Aug 2015, In : Chemical Communications. 51, 63, p. 12605-12608 4 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
108 Downloads (Pure)

Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol

Shen, Y. C., Upadhyayula, R., Cevallos, S., Messick, R. J., Hsia, T., Leese, M. P., Jewett, D. M., Ferrer-Torres, D., Roth, T. M., Dohle, W., Potter, B. V. L. & Barald, K. F., 20 Oct 2015, In : British Journal of Cancer. 113, 8, p. 1158-1167 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

The in vitro and in vivo activity of the microtubule disruptor STX140 is mediated by Hif-1 alpha and CAIX expression

Stengel, C., Newman, S. P., Leese, M. P., Thomas, M. P., Potter, B. V. L., Reed, M. J., Purohit, A. & Foster, P. A., 1 Oct 2015, In : Anticancer Research. 35, 10, p. 5249-5262 14 p.

Research output: Contribution to journalArticle

2014

16- AND 17- DEUTERATED ESTROGEN-3-SULFAMATES AS ESTROGENIC AGENTS

Potter, B., 14 Aug 2014, IPC No. A61K31/565; A61P5/30; C07J41/00;, Patent No. WO2014122480A1, 10 Feb 2014, Priority date 11 Feb 2013, Priority No. 1302368.4

Research output: Patent

Cellular internalisation of an inositol phosphate visualised by using fluorescent InsP5

Riley, A. M., Windhorst, S., Lin, H-Y. & Potter, B. V. L., 3 Jan 2014, In : ChemBiochem. 15, 1, p. 57-67 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

'Click cyclic ADP-ribose': A neutral second messenger mimic

Swarbrick, J. M., Graeff, R., Garnham, C., Thomas, M. P., Galione, A. & Potter, B. V. L., 7 Mar 2014, In : Chemical Communications. 50, 19, p. 2458-2461 4 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
101 Downloads (Pure)

Cyclic adenosine 5′-diphosphate ribose analogs without a southern ribose inhibit ADP-ribosyl cyclase-hydrolase CD38

Swarbrick, J. M., Graeff, R., Zhang, H., Thomas, M. P., Hao, Q. & Potter, B. V. L., 23 Oct 2014, In : Journal of Medicinal Chemistry. 57, 20, p. 8517-8529 13 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
88 Downloads (Pure)

Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response

Pulloor, N. K., Nair, S., Kostic, A. D., Bist, P., Weaver, J. D., Riley, A. M., Tyagi, R., Uchil, P. D., York, J. D., Snyder, S. H., García-Sastre, A., Potter, B. V. L., Lin, R., Shears, S. B., Xavier, R. J. & Krishnan, M. N., 27 Feb 2014, In : PLoS Pathogens. 10, 2, e1003981.

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)

Optimisation of tetrahydroisoquinoline-based chimeric microtubule disruptors

Dohle, W., Leese, M. P., Jourdan, F. L., Chapman, C. J., Hamel, E., Ferrandis, E. & Potter, B. V. L., Aug 2014, In : ChemMedChem. 9, 8, p. 1783-1793 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Synthesis, Antitubulin, and Antiproliferative SAR of C3/C1-Substituted Tetrahydroisoquinolines

Dohle, W., Leese, M. P., Jourdan, F. L., Major, M. R., Bai, R., Hamel, E., Ferrandis, E., Kasprzyk, P. G., Fiore, A., Newman, S. P., Purohit, A. & Potter, B. V. L., Feb 2014, In : ChemMedChem. 9, 2, p. 350-370

Research output: Contribution to journalArticle

12 Citations (Scopus)

Synthesis, anti-tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones

Leese, M. P., Jourdan, F. L., Major, M. R., Dohle, W., Thomas, M. P., Hamel, E., Ferrandis, E., Mahon, M. F., Newman, S. P., Purohit, A. & Potter, B. V. L., Apr 2014, In : ChemMedChem. 9, 4, p. 798-812

Research output: Contribution to journalArticle

11 Citations (Scopus)

Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery

Wang, H., Godage, H. Y., Riley, A. M., Weaver, J. D., Shears, S. B. & Potter, B. V. L., 22 May 2014, In : Chemistry & Biology. 21, 5, p. 689-699 11 p.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)

Synthetic inositol phosphate analogues in complex with PPIP5K2 uncover a substrate capture site as a target for drug discovery

Wang, H., Godage, H., Riley, A., Weaver, J. D., Potter, B. & Shears, S. B., 2014, In : Chemistry & Biology.

Research output: Contribution to journalArticle

Tetrahydroisoquinolinone-based steroidomimetic and chimeric microtubule disruptors

Leese, M. P., Jourdan, F. L., Major, M. R., Dohle, W., Hamel, E., Ferrandis, E., Fiore, A., Kasprzyk, P. G. & Potter, B. V. L., Jan 2014, In : ChemMedChem. 9, 1, p. 85-108 24 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The enzymes of human diphosphoinositol polyphosphate metabolism

Thomas, M. P. & Potter, B. V. L., Jan 2014, In : FEBS Journal. 281, 1, p. 14-33 20 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2013

CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5′-Diphosphate Ribose Template

Moreau, C., Liu, Q., Graeff, R., Wagner, G. K., Thomas, M. P., Swarbrick, J. M., Shuto, S., Lee, H. C., Hao, Q. & Potter, B. V. L., 19 Jun 2013, In : PLoS ONE. 8, 6, 15 p., e66247.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
131 Downloads (Pure)

Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger

Tsuzuki, T., Sakaguchi, N., Kudoh, T., Takano, S., Uehara, M., Murayama, T., Sakurai, T., Hashii, M., Higashida, H., Weber, K., Guse, A. H., Kameda, T., Hirokawa, T., Kumaki, Y., Potter, B. V. L., Fukuda, H., Arisawa, M. & Shuto, S., 24 Jun 2013, In : Angewandte Chemie-International Edition. 52, 26, p. 6633-6637

Research output: Contribution to journalArticle

13 Citations (Scopus)

Inframolecular acid-base and coordination properties towards Na+ and Mg2+ of myo-inositol 1,3,4,5,6-pentakisphosphate: A structural approach to biologically relevant species

Veiga, N., Torres, J., Macho, I., Gómez, K., Godage, H. Y., Riley, A. M., Potter, B. V. L., González, G. & Kremer, C., 7 May 2013, In : Dalton Transactions. 42, 17, p. 6021-6032

Research output: Contribution to journalArticle

6 Citations (Scopus)

Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation

Nebel, M., Schwoerer, A. P., Warszta, D., Siebrands, C. C., Limbrock, A-C., Swarbrick, J. M., Fliegert, R., Weber, K., Bruhn, S., Hohenegger, M., Geisler, A., Herich, L., Schlegel, S., Carrier, L., Eschenhagen, T., Potter, B. V. L., Ehmke, H. & Guse, A. H., 31 May 2013, In : Journal of Biological Chemistry. 288, 22, p. 16017-16030

Research output: Contribution to journalArticle

21 Citations (Scopus)

Regioselective opening of myo-inositol orthoesters: Mechanism and synthetic utility

Godage, H. Y., Riley, A. M., Woodman, T. J., Thomas, M. P., Mahon, M. F. & Potter, B. V. L., 15 Mar 2013, In : Journal of Organic Chemistry. 78, 6, p. 2275-2288

Research output: Contribution to journalArticle

9 Citations (Scopus)

Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by Adenophostin A and its analogues

Saleem, H., Tovey, S. C., Riley, A. M., Potter, B. V. L. & Taylor, C. W., 28 Feb 2013, In : PLoS ONE. 8, 2, e58027.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
84 Downloads (Pure)

Stimulation of Inositol 1,4,5-Trisphosphate (IP3) Receptor Subtypes by Analogues of IP3

Saleem, H., Tovey, S. C., Rahman, T., Riley, A. M., Potter, B. V. L. & Taylor, C. W., 30 Jan 2013, In : PLoS ONE. 8, 1, 54877.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Structure–ativity relationship of adenosine 5′-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists

Moreau, C., Kirchberger, T., Swarbrick, J. M., Bartlett, S. J., Fliegert, R., Yorgan, T., Bauche, A., Harneit, A., Guse, A. H. & Potter, B. V. L., 27 Dec 2013, In : Journal of Medicinal Chemistry. 56, 24, p. 10079-10102

Research output: Contribution to journalArticle

32 Citations (Scopus)

STX2171, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, is efficacious in vivo in a novel hormone-dependent prostate cancer model

Day, J. M., Foster, P. A., Tutill, H. J., Schmidlin, F., Sharland, C. M., Hargrave, J. D., Vicker, N., Potter, B. V. L., Reed, M. J. & Purohit, A., Feb 2013, In : Endocrine-Related Cancer. 20, 1, p. 53-64 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)