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2019

Mechanism of human nail poration by high-repetition-rate, femtosecond laser ablation

Vanstone, S., Stone, J., Gordeev, S. & Guy, R., 1 Oct 2019, In : Drug Delivery and Translational Research. 9, 5, p. 956–967 12 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2 Downloads (Pure)

Potential of iontophoresis as a drug delivery method for midazolam in pediatrics

Djabri, A., Guy, R. & Delgado-Charro, M., 1 Feb 2019, In : European Journal of Pharmaceutical Sciences. 128, p. 137-143 7 p.

Research output: Contribution to journalArticle

Open Access
File
6 Downloads (Pure)

Regulatory Science and Innovation Programme for Europe (ReScIPE): A proposed model

Hines, P. A., Guy, R. H., Brand, A., Humphreys, A. J. & Papaluca-Amati, M., 19 Aug 2019, In : British Journal Of Clinical Pharmacology. p. 1-6 6 p.

Research output: Contribution to journalArticle

Open Access
File

Scanning the horizon: a systematic literature review of methodologies

Hines, P., Yu, L. H., Guy, R. & Papaluca-Amati, M., 27 May 2019, BMJ Open, 9, 5, p. e026764 9 p.

Research output: Contribution to specialist publicationArticle

Open Access
2 Citations (Scopus)
Open Access

Stratum corneum sampling to assess bioequivalence between topical acyclovir products

Pensado-Lopez, A., Chiu, W. S., Cordery, S., Rantou, E., Bunge, A. L., Delgado-Charro, B. & Guy, R., 1 Dec 2019, In : Pharmaceutical Research. 36, 12, p. 180-196 16 p., 180.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
9 Downloads (Pure)

The European Medicines Agency’s goals for regulatory science to 2025

Hines, P., Guy, R., Humphreys, A. & Papaluca-Amati, M., 3 Jun 2019, In : Nature Reviews Drug Discovery. 18, 6, p. 403-404 2 p.

Research output: Contribution to journalComment/debate

Open Access
File
2018
2 Citations (Scopus)
27 Downloads (Pure)

Comparison of patient (POEM), observer (EASI, SASSAD, TIS) and corneometry measures of emollient effectiveness in children with eczema: findings from the COMET feasibility trial

Ridd, M. J., Gaunt, D. M., Guy, R. H., Redmond, N. M., Garfield, K., Hollinghurst, S., Ball, N., Shaw, L., Purdy, S. & Metcalfe, C., 1 Aug 2018, In : British Journal of Dermatology. 179, 2, p. 362-370 9 p.

Research output: Contribution to journalArticle

Open Access
File
Emollients
Eczema
Atopic Dermatitis
Outcome Assessment (Health Care)
1 Citation (Scopus)
28 Downloads (Pure)

Dermal Absorption of Pesticide Residues

Clarke, J., Cordery, S., Morgan, N. A., Knowles, P. & Guy, R., 17 Dec 2018, In : Chemical Research in Toxicology. 31, 12, p. 1356-1363

Research output: Contribution to journalArticle

File
48 Citations (Scopus)
383 Downloads (Pure)

Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform

Lipani, L., Dupont, B. G. R., Doungmene, F., Marken, F., Tyrrell, R. M., Guy, R. H. & Ilie, A., 30 Jun 2018, In : Nature Nanotechnology. 13, 6, p. 504-511 8 p.

Research output: Contribution to journalArticle

Open Access
File
Graphite
glucose
Graphene
Glucose
graphene
3 Citations (Scopus)
25 Downloads (Pure)

Topical bio(in)equivalence of metronidazole formulations in vivo

Pedon de Araujo, T., Moura Fittipaldi, I., Galindo Bedor, D. C., Ludna Duarte, M., Cordery, S., Guy, R., Delgado-Charro, M., Pereira de Santana, D. & Bastos Leal, L., 25 Apr 2018, In : International Journal of Pharmaceutics. 541, 1-2, p. 167-172 6 p.

Research output: Contribution to journalArticle

Open Access
File
Metronidazole
Cornea
Skin
Pharmaceutical Preparations
Biological Availability
2017
8 Citations (Scopus)

Bioequivalence methodologies for topical drug products: in vitro and ex vivo studies with a cortiscosteroid and an anti-fungal drug

Bastos Leal, L., Cordery, S. F., Delgado-Charro, M. B., Bunge, A. L. & Guy, R. H., Apr 2017, In : Pharmaceutical Research. 34, 4, p. 730-737 8 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
120 Downloads (Pure)

Precise laser poration to control drug delivery into and through human nail

Vanstone, S., Cordery, S., Stone, J., Gordeev, S. & Guy, R., 28 Dec 2017, In : Journal of Controlled Release. 268, p. 72-77 6 p.

Research output: Contribution to journalArticle

Open Access
File
Drug and Narcotic Control
Nails
Lasers
Pharmaceutical Preparations
Nail Diseases
4 Citations (Scopus)

Reverse iontophoretic extraction of metabolites from living plants and their identification by ion-chromatography coupled to high resolution mass spectrometry

Gonzalez-Sanchez, M. I., McCullagh, J., Guy, R. & Compton, R., May 2017, In : Phytochemical Analysis. 28, 3, p. 195-201 7 p.

Research output: Contribution to journalArticle

Ion chromatography
ion exchange chromatography
Metabolites
Mass spectrometry
Chromatography
11 Citations (Scopus)
162 Downloads (Pure)

Topical bioavailability of diclofenac from locally-acting, dermatological formulations

Cordery, S. F., Pensado, A., Chiu, W. S., Shehab, M. Z., Bunge, A. L., Delgado-Charro, M. B. & Guy, R. H., 30 Aug 2017, In : International Journal of Pharmaceutics. 529, 1-2, p. 55-64 10 p.

Research output: Contribution to journalArticle

Open Access
File
Diclofenac
Biological Availability
Skin
Pharmaceutical Preparations
Cornea
2016
23 Citations (Scopus)

Assessing the safety of cosmetic chemicals: consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern)

Williams, F. M., Rothe, H., Barrett, G., Chiodini, A., Whyte, J., Cronin, M. T. D., Monteiro-Riviere, N. A., Plautz, J., Roper, C., Westerhout, J., Yang, C. & Guy, R. H., 1 Apr 2016, In : Regulatory Toxicology and Pharmacology. 76, p. 174-186 13 p.

Research output: Contribution to journalArticle

Open Access
Chemical Safety
Decision Trees
Cosmetics
Decision trees
Toxicology
12 Citations (Scopus)

Choice of moisturiser for eczema treatment (COMET): feasibility study of a randomised controlled parallel group trial in children recruited from primary care

Ridd, M., Garfield, K., Gaunt, D., Hollinghurst, S., Redmond, N., Powell, K., Wilson, V., Guy, R., Ball, N., Shaw, L., Purdy, S. & Metcalfe, C., 16 Nov 2016, In : BMJ Open. 6, 11, 9 p., e012021.

Research output: Contribution to journalArticle

Open Access
Emollients
Eczema
Feasibility Studies
Primary Health Care
Therapeutics
10 Citations (Scopus)

Femtosecond pulsed laser ablation to enhance drug delivery across the skin

Garvie-Cook, H., Stone, J. M., Yu, F., Guy, R. H. & Gordeev, S. N., 5 Jan 2016, In : Journal of Biophotonics. 9, 1-2, p. 144-154 11 p.

Research output: Contribution to journalArticle

Laser Therapy
inks
Laser ablation
Pulsed lasers
Drug delivery
7 Citations (Scopus)
158 Downloads (Pure)
Open Access
File
oxidized cellulose
Ibuprofen
Gels
Skin
Cornea
12 Citations (Scopus)
140 Downloads (Pure)

Managing diabetes through the skin: Diagnostic devices

Guy, R., Jun 2016, In : Nature Nanotechnology. 11, 6, p. 493-494 2 p.

Research output: Contribution to journalArticle

Open Access
File
Medical problems
Gold
Skin
sweat
Controlled drug delivery

Metals and the skin: Topical effects and systemic absorption

Guy, R. H., Hostýnek, J. J., Hinz, R. S. & Lorence, C. R., 19 Apr 2016, CRC Press. 431 p.

Research output: Book/ReportBook

6 Citations (Scopus)
104 Downloads (Pure)

Modelling drug flux through microporated skin

Rzhevskiy, A. S., Guy, R. H. & Anissimov, Y. G., 10 Nov 2016, In : Journal of Controlled Release. 241, p. 194-199 6 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Design
Skin
Pharmaceutical Preparations
Theoretical Models
Molecular Weight
13 Citations (Scopus)
125 Downloads (Pure)

The potential of polymeric film-forming systems as sustained delivery platforms for topical drugs

Frederiksen, K., Guy, R. H. & Petersson, K., 2016, In : Expert Opinion on Drug Delivery. 13, 3, p. 349-360

Research output: Contribution to journalArticle

Open Access
File
Skin
Patient Compliance
Pharmaceutical Preparations
Expert Testimony
Drug Delivery Systems
2015
5 Citations (Scopus)
115 Downloads (Pure)

Biophysical elucidation of the mechanism of enhanced drug release and topical delivery from polymeric film-forming systems

Garvie-Cook, H., Frederiksen, K., Petersson, K., Guy, R. & Gordeev, S., 28 Aug 2015, In : Journal of Controlled Release. 212, p. 103-112 10 p.

Research output: Contribution to journalArticle

Open Access
File
Betamethasone Valerate
Triglycerides
Polymers
Skin
Raman Spectrum Analysis
11 Citations (Scopus)
112 Downloads (Pure)

Characterization of Topical Film-Forming Systems Using Atomic Force Microscopy and Raman Microspectroscopy

Garvie-cook, H., Frederiksen, K., Petersson, K., Guy, R. H. & Gordeev, S., Mar 2015, In : Molecular Pharmaceutics. 12, 3, p. 751-757 7 p.

Research output: Contribution to journalArticle

Open Access
File
Plasticizers
Atomic Force Microscopy
Elastic Modulus
Betamethasone Valerate
Skin
13 Citations (Scopus)
73 Downloads (Pure)

Choice of Moisturiser for Eczema Treatment (COMET): Study protocol for a randomized controlled trial

Ridd, M. J., Redmond, N. M., Hollinghurst, S., Ball, N., Shaw, L., Guy, R., Wilson, V., Metcalfe, C. & Purdy, S., 15 Jul 2015, In : Trials. 16, 304.

Research output: Contribution to journalArticle

Open Access
File
Emollients
Eczema
Clinical Protocols
Randomized Controlled Trials
Feasibility Studies
18 Citations (Scopus)
110 Downloads (Pure)

Development and in vitro evaluation of lipid nanoparticle-based dressings for topical treatment of chronic wounds

Gainza, G., Chu, W. S., Guy, R. H., Pedraz, J. L., Hernandez, R. M., Delgado-Charro, B. & Igartua, M., 25 Jul 2015, In : International Journal of Pharmaceutics. 490, 1-2, p. 404-411 8 p.

Research output: Contribution to journalArticle

File
Bandages
Nanoparticles
Lipids
Wounds and Injuries
Fibrin
16 Citations (Scopus)
96 Downloads (Pure)

Drug delivery into microneedle-porated nails from nanoparticle reservoirs

Chiu, W. S., Belsey, N. A., Garrett, N. L., Moger, J., Price, G. J., Delgado-Charro, M. B. & Guy, R. H., 28 Dec 2015, In : Journal of Controlled Release. 220, A, p. 98-106 9 p.

Research output: Contribution to journalArticle

Open Access
File
Nails
Nanoparticles
Pharmaceutical Preparations
Raman Spectrum Analysis
Optical Imaging
28 Citations (Scopus)
174 Downloads (Pure)
Open Access
File
Plasticizers
Drug Delivery Systems
Betamethasone Valerate
Skin
Polymers
12 Citations (Scopus)
110 Downloads (Pure)

In situ detection of salicylate in Ocimum basilicum plant leaves via reverse iontophoresis

González-Sánchez, M. I., Lee, P. T., Guy, R. H. & Compton, R. G., 28 Nov 2015, In : Chemical Communications. 51, 92, p. 16534-16536 3 p.

Research output: Contribution to journalArticle

Open Access
File
Salicylates
Cyclic voltammetry
Electrodes
Chemical analysis
Iontophoresis
4 Citations (Scopus)
103 Downloads (Pure)

In vitro method to quantify dermal absorption of pesticide residues

Clarke, J. F., Cordery, S. F., Morgan, N. A., Knowles, P. K. & Guy, R. H., 16 Feb 2015, In : Chemical Research in Toxicology. 28, 2, p. 166-168

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
116 Downloads (Pure)

Iontophoresis of minoxidil sulphate loaded microparticles, a strategy for follicular drug targeting?

Gelfuso, G. M., Barros, M. A. D. O., Delgado-Charro, M. B., Guy, R. H. & Lopez, R. F. V., Oct 2015, In : Colloids and Surfaces B: Biointerfaces. 134, p. 408-412 5 p.

Research output: Contribution to journalArticle

Open Access
File
Iontophoresis
microparticles
Drug Delivery Systems
Hair Follicle
hair
3 Citations (Scopus)
112 Downloads (Pure)

Iontophoretic transdermal sampling of iohexol as a noninvasive tool to assess glomerular filtration rate

Djabri, A., van’t Hoff, W., Brock, P., Wong, I. C. K., Guy, R. & Delgado-Charro, B., 1 Feb 2015, In : Pharmaceutical Research. 32, 2, p. 590-603 14 p.

Research output: Contribution to journalArticle

Open Access
File
Iohexol
Iontophoresis
Glomerular Filtration Rate
Sampling
Pediatrics
27 Citations (Scopus)
127 Downloads (Pure)

Molecular diffusion in the human nail measured by stimulated Raman scattering microscopy

Chiu, W-S., Belsey, N., Garrett, N. L., Moger, J., Delgado-Charro, M. & Guy, R., 23 Jun 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 25, p. 7725-7730 6 p.

Research output: Contribution to journalArticle

Open Access
File
Raman Spectrum Analysis
Nails
Microscopy
Nail Diseases
Propylene Glycol
10 Citations (Scopus)
105 Downloads (Pure)
Open Access
File
Petasites
Clerodendrum
Vanillic Acid
Medicinal Plants
Cornea
2014
25 Citations (Scopus)
151 Downloads (Pure)
Open Access
File
Buprenorphine
Naltrexone
Drug Combinations
Cocaine
Morphine
30 Citations (Scopus)
93 Downloads (Pure)
Open Access
File
Petasites
Clerodendrum
Vanillic Acid
Apigenin
Skin
7 Citations (Scopus)
129 Downloads (Pure)

Characterisation of skin barrier function using bioengineering and biophysical techniques

Yang, Q. & Guy, R. H., 5 Aug 2014, In : Pharmaceutical Research. 32, 2, p. 445-457

Research output: Contribution to journalArticle

Open Access
File
Bioengineering
Forehead
Cornea
Skin
Forearm
43 Citations (Scopus)
150 Downloads (Pure)

Effective use of transdermal drug delivery in children

Delgado-Charro, M. B. & Guy, R. H., 30 Jun 2014, In : Advanced Drug Delivery Reviews. 73, p. 63-82

Research output: Contribution to journalReview article

File
Pediatrics
Pharmaceutical Preparations
Skin
Cutaneous Administration
Transdermal Patch
39 Citations (Scopus)
167 Downloads (Pure)

Evaluation of drug delivery to intact and porated skin by coherent Raman scattering and fluorescence microscopies

Belsey, N. A., Garrett, N. L., Contreras-Rojas, L. R., Pickup-Gerlaugh, A. J., Price, G. J., Moger, J. & Guy, R. H., 28 Jan 2014, In : Journal of Controlled Release. 174, 28, p. 37-42 6 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Evaluation
Raman Spectrum Analysis
Fluorescence Microscopy
Skin
Microscopy

Imaging drug delivery to skin with coherent raman scattering microscopy

Belsey, N. A., Contreras-Rojas, L. R. & Guy, R. H., 1 Jan 2014, Non Invasive Diagnostic Techniques in Clinical Dermatology. Springer Berlin Heidelberg, p. 225-231 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)
199 Downloads (Pure)

Serious photocontact dermatitis induced by topical ketoprofen depends on the formulation

Guy, R. H., Kuma, H. & Nakanishi, M., May 2014, In : European Journal of Dermatology. 24, 3, p. 365-371 7 p.

Research output: Contribution to journalArticle

Open Access
File
Photoallergic Dermatitis
Ketoprofen
Photosensitivity Disorders
Phototoxic Dermatitis
Photolysis
103 Citations (Scopus)
194 Downloads (Pure)

Transdermal drug delivery: 30 + years of war and still fighting!

Wiedersberg, S. & Guy, R. H., 28 Sep 2014, In : Journal of Controlled Release. 190, p. 150-156

Research output: Contribution to journalArticle

Open Access
File
Pharmaceutical Preparations
Cutaneous Administration
Skin
Technology
Research
2013
9 Citations (Scopus)
110 Downloads (Pure)
Open Access
File
Dielectric Spectroscopy
Iontophoresis
Nails
Permeation
Hydration
21 Citations (Scopus)

Iontophoresis-targeted, follicular delivery of minoxidil sulfate for the treatment of alopecia

Gelfuso, G. M., Gratieri, T., Delgado-Charro, M. B., Guy, R. H. & Vianna Lopez, R. F., 1 May 2013, In : Journal of Pharmaceutical Sciences. 102, 5, p. 1488-1494

Research output: Contribution to journalArticle

Iontophoresis
Alopecia
Minoxidil
Sulfates
Hair Follicle
16 Citations (Scopus)
94 Downloads (Pure)

Mechanical tomography of human corneocytes with a nanoneedle

Beard, J. D., Guy, R. H. & Gordeev, S. N., Jun 2013, In : Journal Of Investigative Dermatology. 133, 6, p. 1565-1571 7 p.

Research output: Contribution to journalArticle

Open Access
File
Nanoneedles
Atomic Force Microscopy
Tomography
Atomic force microscopy
Mechanical properties

Method for non-invasively determining the relative levels of two biological substances. T3

Delgado-Charro, M. & Guy, R., 4 Feb 2013, Patent No. ES2394691T, Priority date 22 Jun 2001, Priority No. EP01114750

Research output: Patent

Products in "Bounty bags" potentially harm newborn skin

Ridd, M., Guy, R., Ball, N., Roberts, A. & Williams, H., 22 Jun 2013, In : BMJ . 346, 7913, f3895.

Research output: Contribution to journalArticle

5 Citations (Scopus)
41 Downloads (Pure)

Transdermal flux predictions for selected selective oestrogen receptor modulators (SERMs): Comparison with experimental results

Güngör, S., Delgado-Charro, M. B., Masini-Etévé, V., Potts, R. O. & Guy, R. H., 28 Dec 2013, In : Journal of Controlled Release. 172, 3, p. 601-606 6 p.

Research output: Contribution to journalArticle

Open Access
File
Selective Estrogen Receptor Modulators
Skin
Danazol
Water
Epidermis
2012
31 Citations (Scopus)

Comparison of gravimetric and spectroscopic approaches to quantify stratum corneum removed by tape-stripping

Mohammed, D., Yang, Q., Guy, R. H., Matts, P. J., Hadgraft, J. & Lane, M. E., Sep 2012, In : European Journal of Pharmaceutics and Biopharmaceutics. 82, 1, p. 171-174

Research output: Contribution to journalArticle

Cornea
Densitometry
Surgical Tape
Volunteers
Proteins