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  • Ravi Acharya

Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration

Negm, O. H., Mackenzie, B., Hamed, M. R., Ahmad, O. A. J., Shone, C. C., Humphreys, D. P., Ravi Acharya, K., Loscher, C. E., Marszalowska, I., Lynch, M., Wilcox, M. H. & Monaghan, T. M., Jun 2017, In : Clinical And Experimental Immunology. 188, 3, p. 437-443

Research output: Contribution to journalArticle

10 Citations (Scopus)

Special issue: Engineering toxins for 21st-century therapies: Introduction

Acharya, K. R., 1 Dec 2011, In : FEBS Journal. 278, 23, p. 4453 1 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors

Masuyer, G., Davies, J. R., Moore, K., Chaddock, J. A. & Acharya, K. R., 1 Sep 2015, In : Scientific Reports. 5, 13397.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons.

Thiyagarajan, N., Ferguson, R., Subramanian, V. & Acharya, K. R., 9 Oct 2012, In : Nature Communications. 3, 14 p., 1121.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Structural basis for the C-domain-selective angiotensin-converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb)

Sturrock, E. D., Lubbe, L., Cozier, G. E., Schwager, S. L. U., Arowolo, A. T., Arendse, L. B., Belcher, E. & Acharya, K. R., 31 May 2019, In : Biochemical Journal. 476, 10, p. 1553-1570 18 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme

Masuyer, G., Douglas, R. G., Sturrock, E. D. & Acharya, K. R., 25 Sep 2015, In : Scientific Reports. 5, 13742.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
103 Downloads (Pure)

Structural basis of multivalent galactose-based dendrimer recognition by human galectin-7

Ramaswamy, S., Sleiman, M. H., Masuyer, G., Arbez-Gindre, C., Micha-Screttas, M., Calogeropoulou, T., Steele, B. R. & Acharya, K. R., 24 Nov 2014, In : FEBS Journal. 282, 2, p. 372-387 16 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster

Akif, M., Masuyer, G., Bingham, R. J., Sturrock, E. D., Isaac, R. E. & Acharya, K. R., Dec 2012, In : FEBS Journal. 279, 24, p. 4525-4534 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Structural basis of substrate specificity in porcine RNase 4

Liang, S. & Acharya, K. R., 1 Mar 2016, In : FEBS Journal. 283, 5, p. 912-928 17 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Structural characterization of angiotensin I-converting enzyme in complex with a selenium analogue of captopril

Akif, M., Masuyer, G., Schwager, S. L. U., Bhuyan, B. J., Mugesh, G., Isaac, R. E., Sturrock, E. D. & Acharya, K. R., Oct 2011, In : FEBS Journal. 278, 19, p. 3644-3650 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis

Bradshaw, W. J., Rehman, S., Pham, T. T. K., Thiyagarajan, N., Lee, R. L., Subramanian, V. & Acharya, K. R., 8 Feb 2017, In : Scientific Reports. 7, p. 1-10 10 p., 41996.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

Structure and activity of a functional derivative of Clostridium botulinum neurotoxin B

Masuyer, G., Beard, M., Cadd, V. A., Chaddock, J. A. & Acharya, K. R., Apr 2011, In : Journal of Structural Biology. 174, 1, p. 52-57 6 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
126 Downloads (Pure)

Structure and function of a Clostridium difficile sortase enzyme

Chambers, C. J., Roberts, A. K., Shone, C. C. & Acharya, K. R., 24 Mar 2015, In : Scientific Reports. 5, 9449.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
114 Downloads (Pure)

Structure and function of cytidine monophosphate kinase from Yersinia pseudotuberculosis, essential for virulence but not for survival

Walker, N. J., Clark, E. A., Ford, D. C., Bullifent, H. L., Mcalister, E. V., Duffield, M. L., Acharya, K. R. & Oyston, P. C. F., 5 Dec 2012, In : Open Biology. 2, Dec, 120142.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Structure based drug design of angiotensin-i converting enzyme inhibitors

Anthony, C. S., Masuyer, G., Sturrock, E. D. & Acharya, K. R., 2012, In : Current Medicinal Chemistry. 19, 6, p. 845-855 11 p.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
166 Downloads (Pure)

Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen

Thiyagarajan, N., Pham, T. T. K., Stinson, B., Sundriyal, A., Tumbale, P., Lizotte-waniewski, M., Brew, K. & Acharya, K. R., 2012, In : Scientific Reports. 2, 940.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Structures of complexes of a metal-independent glycosyltransferase GT6 from Bacteroides ovatus with UDP-N-acetylgalactosamine (UDP-GalNAc) and its hydrolysis products

Pham, T. T. K., Stinson, B., Thiyagarajan, N., Lizotte-Waniewskis, M., Brew, K. & Acharya, K. R., 21 Mar 2014, In : Journal of Biological Chemistry. 289, 12, p. 8041-8050 10 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Structures of engineered Clostridium botulinum neurotoxin derivatives

Masuyer, G., Stancombe, P., Chaddock, J. A. & Acharya, K. R., Dec 2011, In : Acta Crystallographica Section F-Structural Biology and Crystallization Communications. 67, 12, p. 1466-1472 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Super toxins from a super bug: structure and function of Clostridium difficile toxins

Davies, A. H., Roberts, A. K., Shone, C. C. & Acharya, K. R., 15 Jun 2011, In : Biochemical Journal. 436, 3, p. 517-526 10 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

The catalytic activity and secretion of zebrafish RNases are essential for their in vivo function in motor neurons and vasculature

Ferguson, R., Holloway, D. E., Chandrasekhar, A., Acharya, K. R. & Subramanian, V., 1 Feb 2019, In : Scientific Reports. 9, 1, p. 1-15 15 p., 1107.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme

Fienberg, S., Cozier, G. E., Acharya, K. R., Chibale, K. & Sturrock, E. D., 11 Jan 2018, In : Journal of Medicinal Chemistry. 61, 1, p. 344-359 16 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
15 Downloads (Pure)

The molecular structure of the glycoside hydrolase domain of Cwp19 from Clostridium difficile

Bradshaw, W. J., Kirby, J. M., Roberts, A. K., Shone, C. C. & Acharya, K. R., 18 Dec 2017, In : FEBS Journal. 284, 24, p. 4343-4357 15 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

The structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer-associated protein from Clostridium difficile

Bradshaw, W. J., Kirby, J. M., Thiyagarajan, N., Chambers, C. J., Davies, A. H., Roberts, A. K., Shone, C. C. & Acharya, K. R., Jul 2014, In : Acta Crystallographica Section D-Biological Crystallography. 70, 7, p. 1983-1993 11 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
91 Downloads (Pure)

The structure of the S-layer of Clostridium difficile

Bradshaw, W. J., Roberts, A. K., Shone, C. C. & Acharya, K. R., 23 Nov 2017, In : Journal of Cell Communication and Signaling. p. 319-331 13 p.

Research output: Contribution to journalReview article

Open Access
4 Citations (Scopus)

The toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae

Abu Hasan, Z. I., Williams, H., Ismail, N. M., Othman, H., Cozier, G. E., Acharya, K. R. & Isaac, E. R., 27 Mar 2017, In : Scientific Reports. 7, 45409.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
40 Citations (Scopus)

Variations in the Botulinum Neurotoxin Binding Domain and the Potential for Novel Therapeutics.

Davies, J. R., Liu, S. M. & Acharya, K-R., 20 Oct 2018, In : Toxins . 10, 10, p. 1-18 18 p., 421.

Research output: Contribution to journalReview article

Open Access
4 Citations (Scopus)