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  • Barry Potter

THERAPEUTICS USE OF PYRIDINIUM COMPOUNDS TO MODULATE NAADP ACTIVITY

Dowden, J., Galione, A. & Potter, B., 2020, IPC No. A61K31/4425; A61K31/4439; A61K45/06; C07D213/20; C07D213/80; C07D495/04;, Patent No. WO2005054198A3, 6 Dec 2004, Priority date 5 Dec 2003, Priority No. 0328134.0

Research output: Patent

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers

Watt, J. M., Thomas, M. & Potter, B., 15 Oct 2018, In : Scientific Reports. 8, 15268.

Research output: Contribution to journalArticle

Open Access

Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2

Potter, B., Watt, J. M. & Baszczynski, O., 17 May 2019, In : Journal of Organic Chemistry. 84, 10, p. 6143-6157 15 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
13 Downloads (Pure)

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5'-diphosphate ribose (ADPR)

Potter, B., Watt, J. M. & Baszczynski, O., 2020, In : RSC Advances. 10, 3, p. 1776-1785

Research output: Contribution to journalArticle

Open Access

Steroid sulphatase inhibition via aryl sulphamates: Clinical progress, mechanism and future prospects

Potter, B. V. L., 1 Aug 2018, In : Journal of Molecular Endocrinology. 61, 2, p. T233-T252 20 p.

Research output: Contribution to journalReview article

Open Access
20 Citations (Scopus)

Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease

Zhang, B., Watt, J. M., Cordiglieri, C., Dammermann, W., Mahon, M., Flugel, A., Guse, A. H. & Potter, B., 13 Nov 2018, In : Scientific Reports. 8, 17 p., 16775.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Simple synthesis of 32P-labelled inositol hexakisphosphates for study of phosphate transformations

Whitfield, H., Riley, A. M., Diogenous, S., Godage, H. Y., Potter, B. & Brearley, C. A., 27 Jun 2017, In : Plant and Soil.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

SHIP2: structure, function and inhibition

Thomas, M. P., Erneux, C. & Potter, B. V. L., 1 Feb 2017, In : ChemBiochem. 18, 3, p. 233-247

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
268 Downloads (Pure)

Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5'-diphosphate ribose”

Watt, J. M., Graeff, R., Thomas, M. P. & Potter, B., 23 Nov 2017, In : Scientific Reports. 7, 16100.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
36 Downloads (Pure)

Quinazolinone-based Anticancer Agents: Synthesis, Anti-proliferative SAR, Anti-tubulin Activity and Tubulin Co-crystal Structure

Dohle, W., Jourdan, F., Menchon, G., Prota, A., Foster, P. A., Mannion, P., Hamel, E., Thomas, M., Kasprzyk, P. G., Ferrandis, E., Steinmetz, M. O., Leese, M. & Potter, B., 2018, (Unpublished) In : Journal of Medicinal Chemistry. 49 p.

Research output: Contribution to journalArticle

Ligand induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg 1433 and Tyr 1349

Fliegert, R., Watt, J. M., Schöbel, A., Rozewitz, M. D., Moreau, C., Kirchberger, T., Thomas, M. P., Sick, W., Araujo, A. C., Harneit, A., Potter, B. V. L. & Guse, A. H., 16 Jun 2017, In : Biochemical Journal. 474, 13, p. 2159-2175 BCJ20170091.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR

Kühn, F. J. P., Watt, J. M., Potter, B. V. L. & Lückhoff, A., 21 Mar 2019, In : Scientific Reports. 9, 1, p. 1-12 12 p., 4985.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

A Fluorescent Probe Identifies Active Site Ligands of Inositol Pentakisphosphate 2-Kinase

Potter, B. & Godage, H., 11 Oct 2018, In : Journal of Medicinal Chemistry. 61, 19, p. 8838-8846 9 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
35 Downloads (Pure)
Open Access
3 Citations (Scopus)

2ʹ-Deoxyadenosine 5ʹ-diphosphoribose is an endogenous TRPM2 superagonist

Fliegert, R., Bauche, A., Wolf Pérez, A-M., Watt, J. M., Rozewitz, M. D., Winzer, R., Janus, M., Gu, F., Rosche, A., Harneit, A., Flato, M., Moreau, C., Kirchberger, T., Wolters, V., Potter, B. V. L. & Guse, A. H., 1 Sep 2017, In : Nature Chemical Biology. 13, p. 1036-1044 9 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
155 Downloads (Pure)