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  • Laurence Hurst

Why is the X chromosome so odd? Traffic analogy helped us crack the mystery

Hurst, L. D. & Huminiecki, L., 11 Jan 2016, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access

Why did sex evolve? Researchers edge closer to solving longstanding mystery

Hurst, L., 29 Feb 2016, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access

The best way to get children to understand evolution is to teach genetics first, finds study

Hurst, L., Hejmadi, M. & Mead, R., 23 May 2017, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access

The architecture of intra-organism mutation rate variation in plants

Hurst, L., 30 Apr 2019, In : PLoS Biology. 17, 4, 29 p., e3000191.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias

Liu, H., Huang, J., Sun, X., Li, J., Hu, Y., Yu, L., Liti, G., Tian, D., Hurst, L. & Yang, S., 1 Jan 2018, In : Nature Ecology & Evolution. 2, 1, p. 164-173 10 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
41 Downloads (Pure)

Teaching genetics prior to teaching evolution improves evolution understanding but not acceptance

Mead, R., Hejmadi, M. & Hurst, L. D., 31 May 2017, In : PLoS Biology. 15, 5, e2002255.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Scientific aptitude better explains poor responses to teaching of evolution than psychological conflicts

Mead, R., Hejmadi, M. & Hurst, L. D., 1 Feb 2018, In : Nature Ecology & Evolution. 2, 2, p. 388-394 7 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
102 Downloads (Pure)
Open Access
6 Citations (Scopus)

Purifying selection on exonic splice enhancers in intronless genes

Savisaar, R. & Hurst, L. D., Jun 2016, In : Molecular Biology and Evolution. 33, 6, p. 1396-1418

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
133 Downloads (Pure)

Pluripotency and the endogenous retrovirus HERVH: conflict or serendipity?

Izsvák, Z., Wang, J., Singh, M., Mager, D. L. & Hurst, L. D., 1 Jan 2016, In : Bioessays. 38, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Mutation rate analysis via parent- progeny sequencing of the perennial peach. II. No evidence for recombination associated mutation

Wang, L., Zhang, Y., Qin, C., Tian, D., Yang, S. & Hurst, L. D., 26 Oct 2016, In : Proceedings of the Royal Society B: Biological Sciences. 283, 1841, 20161785.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
122 Downloads (Pure)

Mutation rate analysis via parent– progeny sequencing of the perennial peach. I. A low rate in woody perennials and a higher mutagenicity in hybrids

Xie, Z., Wang, L., Wang, L., Wang, Z., Lu, Z., Tian, D., Yang, S. & Hurst, L. D., 26 Oct 2016, In : Proceedings of the Royal Society B: Biological Sciences. 283, 1841, 20161016.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
113 Downloads (Pure)

Male Mutation Bias Is the Main Force Shaping Chromosomal Substitution Rates in Monotreme Mammals

Link, V., Aguilar-Gómez, D., Ramírez-Suástegui, C., Hurst, L. D. & Cortez, D., 1 Sep 2017, In : Genome biology and evolution. 9, 9, p. 2198-2210 13 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression

Wang, J., Singh, M., Sun, C., Besser, D., Prigione, A., Ivics, Z., Hurst, L. D. & Izsvák, Z., 1 Feb 2016, In : Nature Protocols. 11, 2, p. 327-346 20 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

In eubacteria, unlike eukaryotes, there is no evidence for selection favouring fail-safe 3' additional stop codons

Ho, A. T. & Hurst, L. D., 17 Sep 2019, In : Plos Genetics. 15, 9, p. 1-32 32 p., e1008386.

Research output: Contribution to journalArticle

Open Access
Open Access
File
11 Citations (Scopus)
34 Downloads (Pure)

Human evolution is still happening – possibly faster than ever

Hurst, L. D., 14 Nov 2018, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access

Faster Evolving Primate Genes Are More Likely to Duplicate

O'Toole, Á. N., Hurst, L. D. & McLysaght, A., 1 Jan 2018, In : Molecular Biology and Evolution. 35, 1, p. 107-118 12 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Exonic splice regulation imposes strong selection at synonymous sites

Savisaar, R. & Hurst, L., 1 Oct 2018, In : Genome Research. 28, 10, p. 1442-1454 13 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Evidence for the Success of a Quantitative Assessment Instrument for Teaching Evolution in Primary Schools in England

Buchan, L., Hejmadi, M. & Hurst, L., 2019, Evolution Education Re-considered. Harms, U. & Reiss, M. (eds.). UK: Springer, p. 21-40 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Estimating the prevalence of functional exonic splice regulatory information

Savisaar, R. & Hurst, L. D., 1 Sep 2017, In : Human Molecular Genetics. 136, 9, p. 1059-1078 20 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA

Yokoyama, M., Stevens, E., Laabei, M., Bacon, L., Heesom, K., Bayliss, S., Ooi, N., O'Neill, A. J., Murray, E., Williams, P., Lubben, A., Reeksting, S., Meric, G., Pascoe, B., Sheppard, S. K., Recker, M., Hurst, L. D. & Massey, R. C., 18 Jul 2018, In : Genome Biology. 19, 1, p. 1-12 12 p., 94.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids

Thumann, G., Harmening, N., Prat-Souteyrand, C., Marie, C., Pastor, M., Sebe, A., Miskey, C., Hurst, L. D., Diarra, S., Kropp, M., Walter, P., Scherman, D., Ivics, Z., Izsvák, Z. & Johnen, S., 17 Mar 2017, In : Molecular Therapy - Nucleic Acids. 6, p. 302-314 13 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica

Mühlhausen, S., Schmitt, H. D., Pan, K. T., Plessmann, U., Urlaub, H., Hurst, L. D. & Kollmar, M., 9 Jul 2018, In : Current Biology. 28, 13, p. 2046-2057 18 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

ENDOGENOUS RETROVIRUS TRANSCRIPTION AS A MARKER FOR PRIMATE NAÏVE PLURIPOTENT STEM CELLS

Wang, J., Izsvák, Z. & Hurst, L., 2019, Patent No. WO 2016/055519 A1(EP3204490, US2017313978), 7 Oct 2015, Priority date 7 Oct 2014, Priority No. 10 2014 114 558.5

Research output: Patent

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker

Zadora, J., Singh, M., Herse, F., Przybyl, L., Haasse, N., Golic, M., Yung, H. W., Huppertz, B., Cartwright, J. E., Whitley, G., Johnsen, G. M., Levi, G., Isbruch, A., Schulz, H., Luft, F. C., Muller, D. N., Staff, A. C., Hurst, L., Dechend, R. & Izsvak, Z., 7 Nov 2017, In : Circulation. 136, 19, p. 1824-1839 16 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Direct determination of the mutation rate in the bumblebee reveals evidence for weak recombination-associated mutation and an approximate rate constancy in insects

Liu, H., Jia, Y., Sun, X., Tian, D., Hurst, L. D. & Yang, S., 1 Jan 2017, In : Molecular Biology and Evolution. 34, 1, p. 119-130 12 p.

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)
Open Access
File
23 Citations (Scopus)
127 Downloads (Pure)

Depletion of somatic mutations in splicing-associated sequences in cancer genomes

Hurst, L. & Batada, N. N., 7 Nov 2017, In : Genome Biology. 18, 1, 12 p., 213.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Conditional expression explains molecular evolution of social genes in a microbe

de Oliveira, J. L., Morales, A. C., Stewart, B., Gruenheit, N., Engelmoer, J., Brown, S. B., de Brito, R. A., Hurst, L. D., Urrutia, A. O., Thompson, C. R. L. & Wolf, J. B., 23 Jul 2019, In : Nature Communications. 10, 1, p. 1-12 12 p., 3284.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Comparative analyses of selection operating on non-translated intergenic regions of diverse bacterial species

Thorpe, H. A., Bayliss, S. C., Hurst, L. D. & Feil, E. J., 5 May 2017, In : Genetics. 206, 1, p. 363-376 195784.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Codon Usage and Splicing Jointly Influence mRNA Localization

Hurst, L., 22 Apr 2020, In : Cell Systems. 10, 4, p. 351-362

Research output: Contribution to journalArticle

Open Access

Both maintenance and avoidance of RNA-binding protein interactions constrain coding region evolution

Savisaar, R. & Hurst, L., 1 May 2017, In : Molecular Biology and Evolution. 34, 5, p. 1110-1126

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
155 Downloads (Pure)
Open Access
Open Access
3 Citations (Scopus)

A century of bias in genetics and evolution

Hurst, L., 12 Jun 2019, In : Heredity. 123, 1, p. 33-43 11 p.

Research output: Contribution to journalReview article

Open Access
File
28 Downloads (Pure)