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  • Barry Potter

16- AND 17- DEUTERATED ESTROGEN-3-SULFAMATES AS ESTROGENIC AGENTS

Potter, B., 14 Aug 2014, IPC No. A61K31/565; A61P5/30; C07J41/00;, Patent No. WO2014122480A1, 10 Feb 2014, Priority date 11 Feb 2013, Priority No. 1302368.4

Research output: Patent

2ʹ-Deoxyadenosine 5ʹ-diphosphoribose is an endogenous TRPM2 superagonist

Fliegert, R., Bauche, A., Wolf Pérez, A-M., Watt, J. M., Rozewitz, M. D., Winzer, R., Janus, M., Gu, F., Rosche, A., Harneit, A., Flato, M., Moreau, C., Kirchberger, T., Wolters, V., Potter, B. V. L. & Guse, A. H., 1 Sep 2017, In : Nature Chemical Biology. 13, p. 1036-1044 9 p.

Research output: Contribution to journalArticle

Open Access
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23 Citations (Scopus)
150 Downloads (Pure)

Aberrant cyclization affords a C-6 modified cyclic adenosine 5′-diphosphoribose analogue with biological activity in Jurkat T cells

Moreau, C., Kirchberger, T., Zhang, B., Thomas, M. P., Weber, K., Guse, A. H. & Potter, B. V. L., 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1478-1489

Research output: Contribution to journalArticle

14 Citations (Scopus)
Open Access
3 Citations (Scopus)

Adamantyl carboxamides and acetamides as potent human 11β- hydroxysteroid dehydrogenase type 1 inhibitors

Su, X., Halem, H. A., Thomas, M. P., Moutrille, C., Culler, M. D., Vicker, N. & Potter, B. V. L., 1 Nov 2012, In : Bioorganic and Medicinal Chemistry. 20, 21, p. 6394-6402

Research output: Contribution to journalArticle

6 Citations (Scopus)

Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11 beta-hydroxysteroid dehydrogenase type 1

Su, X., Pradaux-Caggiano, F., Vicker, N., Thomas, M. P., Halem, H., Culler, M. D. & Potter, B. V. L., 5 Sep 2011, In : ChemMedChem. 6, 9, p. 1616-1629

Research output: Contribution to journalArticle

10 Citations (Scopus)

A Fluorescent Probe Identifies Active Site Ligands of Inositol Pentakisphosphate 2-Kinase

Potter, B. & Godage, H., 11 Oct 2018, In : Journal of Medicinal Chemistry. 61, 19, p. 8838-8846 9 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
30 Downloads (Pure)

Antagonism of NAADP mediated calcium signaling ameliorates arrythmias in the heart

Nebel, M., Schworer, A., Siebrands, C. C., Limbrock, A-C., Swarbrick, J. M., Hohenegger, M., Geisler, A., Herich, L., Schlegel, S., Carrier, L., Eschenhagen, T., Potter, B. V. L., Ehmke, H. & Guse, A. H., 2012, (Accepted/In press) In : Circulation.

Research output: Contribution to journalArticle

Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates

Wood, P. M., Woo, L. W. L., Thomas, M. P., Mahon, M. F., Purohit, A. & Potter, B. V. L., 1 Aug 2011, In : ChemMedChem. 6, 8, p. 1423-1438

Research output: Contribution to journalArticle

41 Citations (Scopus)

A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion

Raimondi, C., Calleja, V., Ferro, R., Fantin, A., Riley, A. M., Potter, B. V. L., Brennan, C. H., Maffucci, T., Larijani, B. & Falasca, M., 20 May 2016, In : Scientific Reports. 6, 26142.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
82 Downloads (Pure)

A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery

Mills, S. J., Persson, C., Cozier, G., Thomas, M. P., Trésaugues, L., Erneux, C., Riley, A. M., Nordlund, P. & Potter, B. V. L., 18 May 2012, In : ACS Chemical Biology. 7, 5, p. 822-828

Research output: Contribution to journalArticle

23 Citations (Scopus)

Calcium Signalling Triggered by NAADP in T Cells Determines Cell Shape and Motility During Immune Synapse Formation

Nebel, M., Zhang, B., Odoardi, F., Flugel, A., Potter, B. & Guse, A. H., 2015, In : Messenger. 4, 1, p. 104-111

Research output: Contribution to journalArticle

Open Access
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117 Downloads (Pure)

CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5′-Diphosphate Ribose Template

Moreau, C., Liu, Q., Graeff, R., Wagner, G. K., Thomas, M. P., Swarbrick, J. M., Shuto, S., Lee, H. C., Hao, Q. & Potter, B. V. L., 19 Jun 2013, In : PLoS ONE. 8, 6, 15 p., e66247.

Research output: Contribution to journalArticle

Open Access
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20 Citations (Scopus)
129 Downloads (Pure)

Cellular internalisation of an inositol phosphate visualised by using fluorescent InsP5

Riley, A. M., Windhorst, S., Lin, H-Y. & Potter, B. V. L., 3 Jan 2014, In : ChemBiochem. 15, 1, p. 57-67 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

'Click cyclic ADP-ribose': A neutral second messenger mimic

Swarbrick, J. M., Graeff, R., Garnham, C., Thomas, M. P., Galione, A. & Potter, B. V. L., 7 Mar 2014, In : Chemical Communications. 50, 19, p. 2458-2461 4 p.

Research output: Contribution to journalArticle

Open Access
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21 Citations (Scopus)
99 Downloads (Pure)

Contribution of phosphates and adenine to the potency of adenophostins at the IP 3 receptor: synthesis of all possible bisphosphates of adenophostin A

Sureshan, K. M., Riley, A. M., Thomas, M. P., Tovey, S. C., Taylor, C. W. & Potter, B. V. L., 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1706-1720

Research output: Contribution to journalArticle

15 Citations (Scopus)

Crystal structures of II beta-hydroxysteroid dehydrogenase type I and their use in drug discovery

Thomas, M. P. & Potter, B. V. L., Mar 2011, In : Future Medicinal Chemistry. 3, 3, p. 367-390

Research output: Contribution to journalArticle

22 Citations (Scopus)

Crystal structures of type-II inositol polyphosphate 5-phosphatase INPP5B with synthetic inositol polyphosphate surrogates reveal new mechanistic insights for the inositol 5-phosphatase family

Mills, S. J., Silvander, C., Cozier, G., Trésaugues, L., Nordlund, P. & Potter, B. V. L., 8 Mar 2016, In : Biochemistry. 55, 9, p. 1384-1397

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
124 Downloads (Pure)

Cyclic adenosine 5′-diphosphate ribose analogs without a southern ribose inhibit ADP-ribosyl cyclase-hydrolase CD38

Swarbrick, J. M., Graeff, R., Zhang, H., Thomas, M. P., Hao, Q. & Potter, B. V. L., 23 Oct 2014, In : Journal of Medicinal Chemistry. 57, 20, p. 8517-8529 13 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
86 Downloads (Pure)

Design, Synthesis, and Chemical and Biological Properties of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose

Tsuzuki, T., Takano, S., Sakaguchi, N., Kudoh, T., Murayama, T., Sakurai, T., Higashida, H., Weber, K., Guse, A. H., Kameda, T., Hirokawa, T., Kumaki, Y., Arisawa, M., Potter, B. & Shuto, S., Jun 2015, In : Messenger. 3, 1-2, p. 35-51 17 p.

Research output: Contribution to journalArticle

Open Access
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125 Downloads (Pure)

Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger

Tsuzuki, T., Sakaguchi, N., Kudoh, T., Takano, S., Uehara, M., Murayama, T., Sakurai, T., Hashii, M., Higashida, H., Weber, K., Guse, A. H., Kameda, T., Hirokawa, T., Kumaki, Y., Potter, B. V. L., Fukuda, H., Arisawa, M. & Shuto, S., 24 Jun 2013, In : Angewandte Chemie-International Edition. 52, 26, p. 6633-6637

Research output: Contribution to journalArticle

13 Citations (Scopus)

Designer small molecules to target calcium signalling

Swarbrick, J. M., Riley, A. M., Mills, S. J. & Potter, B. V. L., 1 Jun 2015, In : Biochemical Society Transactions. 43, 3, p. 417-425 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Designer small molecules to target calcium signalling

Swarbrick, J., Riley, A., Mills, S. & Potter, B., 2015.

Research output: Contribution to conferencePaper

File
4 Citations (Scopus)
108 Downloads (Pure)

Determination of neo-and D-chiro-inositol hexakisphosphate in soils by solution 31P NMR spectroscopy

Turner, B. L., Cheesman, A. W., Godage, H. Y., Riley, A. M. & Potter, B. V. L., 2012, In : Environmental Science & Technology. 46, 9, p. 4994-5002

Research output: Contribution to journalArticle

90 Citations (Scopus)

Development of steroid sulfatase inhibitors

Woo, L. W. L., Purohit, A. & Potter, B. V. L., 4 Jul 2011, In : Molecular and Cellular Endocrinology. 340, 2, p. 175-185

Research output: Contribution to journalArticle

Open Access
File
41 Citations (Scopus)
146 Downloads (Pure)

Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR

Kühn, F. J. P., Watt, J. M., Potter, B. V. L. & Lückhoff, A., 21 Mar 2019, In : Scientific Reports. 9, 1, p. 1-12 12 p., 4985.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Womens Health

Thomas, M. P. & Potter, B. V. L., 8 Oct 2015, In : Journal of Medicinal Chemistry. 58, 19, p. 7634-7658 25 p.

Research output: Contribution to journalReview article

36 Citations (Scopus)

Discovery of adamantyl heterocyclic ketones as potent 11 beta-hydroxysteroid dehydrogenase type 1 inhibitors

Su, X., Vicker, N., Thomas, M. P., Pradaux-Caggiano, F., Halem, H., Culler, M. D. & Potter, B. V. L., 1 Aug 2011, In : ChemMedChem. 6, 8, p. 1439-1451

Research output: Contribution to journalArticle

8 Citations (Scopus)

Estrogen O-sulfamates and their analogues: clinical steroid sulfatase inhibitors with broad potential

Thomas, M. P. & Potter, B. V. L., 1 Sep 2015, In : Journal of Steroid Biochemistry and Molecular Biology. 153, p. 160-169 10 p., 4391.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Fibrinogen—a possible extracellular target for inositol phosphates

Grint, T., Riley, A. M., Mills, S. J., Potter, B. V. L. & Safrany, S. T., 1 Dec 2012, In : Messenger. 1, 2, p. 160-166

Research output: Contribution to journalArticle

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase

Riley, A. M., Wang, H., Weaver, J. D., Shears, S. B. & Potter, B. V. L., 24 Oct 2012, In : Chemical Communications. 48, 92, p. 11292-11294 3 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response

Pulloor, N. K., Nair, S., Kostic, A. D., Bist, P., Weaver, J. D., Riley, A. M., Tyagi, R., Uchil, P. D., York, J. D., Snyder, S. H., García-Sastre, A., Potter, B. V. L., Lin, R., Shears, S. B., Xavier, R. J. & Krishnan, M. N., 27 Feb 2014, In : PLoS Pathogens. 10, 2, e1003981.

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)

Hybrid dual aromatase-steroid sulfatase inhibitors with exquisite picomolar inhibitory activity

Woo, L. W. L., Bubert, C., Purohit, A. & Potter, B. V. L., Mar 2011, In : ACS Medicinal Chemistry Letters. 2, 3, p. 243-247

Research output: Contribution to journalArticle

27 Citations (Scopus)

Inframolecular acid-base and coordination properties towards Na+ and Mg2+ of myo-inositol 1,3,4,5,6-pentakisphosphate: A structural approach to biologically relevant species

Veiga, N., Torres, J., Macho, I., Gómez, K., Godage, H. Y., Riley, A. M., Potter, B. V. L., González, G. & Kremer, C., 7 May 2013, In : Dalton Transactions. 42, 17, p. 6021-6032

Research output: Contribution to journalArticle

6 Citations (Scopus)

Insights into the activation mechanism of class I HDAC complexes by inositol phosphates

Watson, P. J., Millard, C. J., Riley, A. M., Robertson, N. S., Wright, L. C., Godage, H. Y., Cowley, S. M., Jamieson, A. G., Potter, B. V. L. & Schwabe, J. W. R., 25 Apr 2016, In : Nature Communications. 7, 11262.

Research output: Contribution to journalArticle

Open Access
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69 Citations (Scopus)
111 Downloads (Pure)

In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer

Stengel, C., Newman, S. P., Day, J. M., Chander, S. K., Jourdan, F. L., Leese, M. P., Ferrandis, E., Regis-lydi, S., Potter, B. V. L., Reed, M. J., Purohit, A. & Foster, P. A., 15 Jul 2015, In : British Journal of Cancer. 111, 2, p. 300-308

Research output: Contribution to journalArticle

10 Citations (Scopus)

Ligand induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg 1433 and Tyr 1349

Fliegert, R., Watt, J. M., Schöbel, A., Rozewitz, M. D., Moreau, C., Kirchberger, T., Thomas, M. P., Sick, W., Araujo, A. C., Harneit, A., Potter, B. V. L. & Guse, A. H., 16 Jun 2017, In : Biochemical Journal. 474, 13, p. 2159-2175 BCJ20170091.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation

Nebel, M., Schwoerer, A. P., Warszta, D., Siebrands, C. C., Limbrock, A-C., Swarbrick, J. M., Fliegert, R., Weber, K., Bruhn, S., Hohenegger, M., Geisler, A., Herich, L., Schlegel, S., Carrier, L., Eschenhagen, T., Potter, B. V. L., Ehmke, H. & Guse, A. H., 31 May 2013, In : Journal of Biological Chemistry. 288, 22, p. 16017-16030

Research output: Contribution to journalArticle

21 Citations (Scopus)

Novel Inositol Phosphate Derivatives

Falasca, M., Riley, A., Godage, H. & Potter, B., 3 Jun 2011, IPC No. A61K31/661, Patent No. WO2011064559 (A2)

Research output: Patent

Optimisation of tetrahydroisoquinoline-based chimeric microtubule disruptors

Dohle, W., Leese, M. P., Jourdan, F. L., Chapman, C. J., Hamel, E., Ferrandis, E. & Potter, B. V. L., Aug 2014, In : ChemMedChem. 9, 8, p. 1783-1793 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Quinazolinone-based Anticancer Agents: Synthesis, Anti-proliferative SAR, Anti-tubulin Activity and Tubulin Co-crystal Structure

Dohle, W., Jourdan, F., Menchon, G., Prota, A., Foster, P. A., Mannion, P., Hamel, E., Thomas, M., Kasprzyk, P. G., Ferrandis, E., Steinmetz, M. O., Leese, M. & Potter, B., 2018, (Unpublished) In : Journal of Medicinal Chemistry. 49 p.

Research output: Contribution to journalArticle

Regioselective opening of myo-inositol orthoesters: Mechanism and synthetic utility

Godage, H. Y., Riley, A. M., Woodman, T. J., Thomas, M. P., Mahon, M. F. & Potter, B. V. L., 15 Mar 2013, In : Journal of Organic Chemistry. 78, 6, p. 2275-2288

Research output: Contribution to journalArticle

9 Citations (Scopus)

Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5'-diphosphate ribose”

Watt, J. M., Graeff, R., Thomas, M. P. & Potter, B., 23 Nov 2017, In : Scientific Reports. 7, 16100.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
35 Downloads (Pure)

SHIP2: structure, function and inhibition

Thomas, M. P., Erneux, C. & Potter, B. V. L., 1 Feb 2017, In : ChemBiochem. 18, 3, p. 233-247

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
249 Downloads (Pure)

Simple synthesis of 32P-labelled inositol hexakisphosphates for study of phosphate transformations

Whitfield, H., Riley, A. M., Diogenous, S., Godage, H. Y., Potter, B. & Brearley, C. A., 27 Jun 2017, In : Plant and Soil.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease

Zhang, B., Watt, J. M., Cordiglieri, C., Dammermann, W., Mahon, M., Flugel, A., Guse, A. H. & Potter, B., 13 Nov 2018, In : Scientific Reports. 8, 17 p., 16775.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Steroidomimetic tetrahydroisoquinolines for the design of new microtubule disruptors

Leese, M. P., Jourdan, F., Dohle, W., Kimberley, M. R., Thomas, M. P., Bai, R., Hamel, E., Ferrandis, E. & Potter, B. V. L., 2012, In : ACS Medicinal Chemistry Letters. 3, 1, p. 5-9

Research output: Contribution to journalArticle

27 Citations (Scopus)

Steroid sulfatase: a pivotal player in estrogen synthesis and metabolism

Purohit, A., Woo, L. W. L. & Potter, B. V. L., 4 Jul 2011, In : Molecular and Cellular Endocrinology. 340, 2, p. 154-160

Research output: Contribution to journalArticle

Open Access
File
49 Citations (Scopus)
150 Downloads (Pure)

Steroid sulphatase inhibition via aryl sulphamates: Clinical progress, mechanism and future prospects

Potter, B. V. L., 1 Aug 2018, In : Journal of Molecular Endocrinology. 61, 2, p. T233-T252 20 p.

Research output: Contribution to journalReview article

Open Access
19 Citations (Scopus)

Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by Adenophostin A and its analogues

Saleem, H., Tovey, S. C., Riley, A. M., Potter, B. V. L. & Taylor, C. W., 28 Feb 2013, In : PLoS ONE. 8, 2, e58027.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
83 Downloads (Pure)