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  • Laurence Hurst

A century of bias in genetics and evolution

Hurst, L., 12 Jun 2019, In : Heredity. 123, 1, p. 33-43 11 p.

Research output: Contribution to journalReview article

Open Access
File
22 Downloads (Pure)
Open Access
3 Citations (Scopus)
Open Access

A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators

Hurst, L. D., Sachenkova, O., Daub, C., Forrest, A. R. R. & Huminiecki, L., 31 Jul 2014, In : Genome Biology. 15, 7, 413.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Atypical AT skew in firmicute genomes results from selection and not from mutation

Charneski, C. A., Honti, F., Bryant, J. M., Hurst, L. D. & Feil, E. J., 15 Sep 2011, In : Plos Genetics. 7, 9, 14 p., e1002283.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Birt Hogg-Dube Syndrome-Associated FLCN Mutations Disrupt Protein Stability

Nahorski, M. S., Reiman, A., Lim, D. H. K., Nookala, R. K., Seabra, L., Lu, X. H., Fenton, J., Boora, U., Nordenskjold, M., Latif, F., Hurst, L. D. & Maher, E. R., Aug 2011, In : Human Mutation. 32, 8, p. 921-929 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Both maintenance and avoidance of RNA-binding protein interactions constrain coding region evolution

Savisaar, R. & Hurst, L., 1 May 2017, In : Molecular Biology and Evolution. 34, 5, p. 1110-1126

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
154 Downloads (Pure)

Codon Usage and Splicing Jointly Influence mRNA Localization

Hurst, L., 22 Apr 2020, In : Cell Systems. 10, 4, p. 351-362

Research output: Contribution to journalArticle

Open Access

Comparative analyses of selection operating on non-translated intergenic regions of diverse bacterial species

Thorpe, H. A., Bayliss, S. C., Hurst, L. D. & Feil, E. J., 5 May 2017, In : Genetics. 206, 1, p. 363-376 195784.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Competition between transposable elements and mutator genes in bacteria

Feher, T., Bogos, B., Mehi, O., Fekete, G., Csorgo, B., Kovacs, K., Posfai, G., Papp, B., Hurst, L. D. & Pal, C., 1 Oct 2012, In : Molecular Biology and Evolution. 29, 10, p. 3153-3159

Research output: Contribution to journalArticle

20 Citations (Scopus)

Conditional expression explains molecular evolution of social genes in a microbe

de Oliveira, J. L., Morales, A. C., Stewart, B., Gruenheit, N., Engelmoer, J., Brown, S. B., de Brito, R. A., Hurst, L. D., Urrutia, A. O., Thompson, C. R. L. & Wolf, J. B., 23 Jul 2019, In : Nature Communications. 10, 1, p. 1-12 12 p., 3284.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Depletion of somatic mutations in splicing-associated sequences in cancer genomes

Hurst, L. & Batada, N. N., 7 Nov 2017, In : Genome Biology. 18, 1, 12 p., 213.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
Open Access
File
23 Citations (Scopus)
125 Downloads (Pure)

Direct and indirect consequences of meiotic recombination: Implications for genome evolution

Webster, M. T. & Hurst, L. D., Mar 2012, In : Trends in Genetics. 28, 3, p. 101-109 9 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Direct determination of the mutation rate in the bumblebee reveals evidence for weak recombination-associated mutation and an approximate rate constancy in insects

Liu, H., Jia, Y., Sun, X., Tian, D., Hurst, L. D. & Yang, S., 1 Jan 2017, In : Molecular Biology and Evolution. 34, 1, p. 119-130 12 p.

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

Garfield, A. S., Cowley, M., Smith, F. M., Moorwood, K., Stewart-Cox, J. E., Gilroy, K., Baker, S., Xia, J., Dalley, J. W., Hurst, L. D., Wilkinson, L. S., Isles, A. R. & Ward, A., 27 Jan 2011, In : Nature. 469, 7331, p. 534-538 5 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker

Zadora, J., Singh, M., Herse, F., Przybyl, L., Haasse, N., Golic, M., Yung, H. W., Huppertz, B., Cartwright, J. E., Whitley, G., Johnsen, G. M., Levi, G., Isbruch, A., Schulz, H., Luft, F. C., Muller, D. N., Staff, A. C., Hurst, L., Dechend, R. & Izsvak, Z., 7 Nov 2017, In : Circulation. 136, 19, p. 1824-1839 16 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Duplication and retention biases of essential and non-essential genes revealed by systematic knockdown analyses

Woods, S., Coghlan, A., Rivers, D., Warnecke, T., Jeffries, S. J., Kwon, T., Rogers, A., Hurst, L. & Ahringer, J., 9 May 2013, In : Plos Genetics. 9, 5, e1003330.

Research output: Contribution to journalArticle

21 Citations (Scopus)

ENDOGENOUS RETROVIRUS TRANSCRIPTION AS A MARKER FOR PRIMATE NAÏVE PLURIPOTENT STEM CELLS

Wang, J., Izsvák, Z. & Hurst, L., 2019, Patent No. WO 2016/055519 A1(EP3204490, US2017313978), 7 Oct 2015, Priority date 7 Oct 2014, Priority No. 10 2014 114 558.5

Research output: Patent

Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica

Mühlhausen, S., Schmitt, H. D., Pan, K. T., Plessmann, U., Urlaub, H., Hurst, L. D. & Kollmar, M., 9 Jul 2018, In : Current Biology. 28, 13, p. 2046-2057 18 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids

Thumann, G., Harmening, N., Prat-Souteyrand, C., Marie, C., Pastor, M., Sebe, A., Miskey, C., Hurst, L. D., Diarra, S., Kropp, M., Walter, P., Scherman, D., Ivics, Z., Izsvák, Z. & Johnen, S., 17 Mar 2017, In : Molecular Therapy - Nucleic Acids. 6, p. 302-314 13 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Environmentally responsive genome-wide accumulation of de novo Arabidopsis thaliana mutations and epimutations

Jiang, C., Mithani, A., Belfield, E. J., Mott, R., Hurst, L. D. & Harberd, N. P., 1 Nov 2014, In : Genome Research. 24, 11, p. 1821-1829 9 p.

Research output: Contribution to journalArticle

Open Access
74 Citations (Scopus)

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA

Yokoyama, M., Stevens, E., Laabei, M., Bacon, L., Heesom, K., Bayliss, S., Ooi, N., O'Neill, A. J., Murray, E., Williams, P., Lubben, A., Reeksting, S., Meric, G., Pascoe, B., Sheppard, S. K., Recker, M., Hurst, L. D. & Massey, R. C., 18 Jul 2018, In : Genome Biology. 19, 1, p. 1-12 12 p., 94.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Error prevention and mitigation as forces in the evolution of genes and genomes

Warnecke, T. & Hurst, L. D., Dec 2011, In : Nature Reviews Genetics. 12, 12, p. 875-881 7 p.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
131 Downloads (Pure)

Estimating the prevalence of functional exonic splice regulatory information

Savisaar, R. & Hurst, L. D., 1 Sep 2017, In : Human Molecular Genetics. 136, 9, p. 1059-1078 20 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Evidence for deep phylogenetic conservation of exonic splice-related constraints: Splice-related skews at exonic ends in the brown alga Ectocarpus are common and resemble those seen in humans

Wu, X., Tronholm, A., Fernandez Cáceres, E., Tovar-Corona, J. M., Chen, L., Urrutia, A. O. & Hurst, L. D., 2013, In : Genome biology and evolution. 5, 9, p. 1731-1745 15 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
120 Downloads (Pure)

Evidence for the Success of a Quantitative Assessment Instrument for Teaching Evolution in Primary Schools in England

Buchan, L., Hejmadi, M. & Hurst, L., 2019, Evolution Education Re-considered. Harms, U. & Reiss, M. (eds.). UK: Springer, p. 21-40 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients

Yin, S., Yang, J., Lin, B., Deng, W., Zhang, Y., Yi, X., Shi, Y., Tao, Y., Cai, J., Wu, C-I., Zhao, G., Hurst, L. D., Zhang, J., Hu, L. & Kong, X., 12 Aug 2014, In : Scientific Reports. 4, 6036.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
119 Downloads (Pure)

Exonic splice regulation imposes strong selection at synonymous sites

Savisaar, R. & Hurst, L., 1 Oct 2018, In : Genome Research. 28, 10, p. 1442-1454 13 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Faster Evolving Primate Genes Are More Likely to Duplicate

O'Toole, Á. N., Hurst, L. D. & McLysaght, A., 1 Jan 2018, In : Molecular Biology and Evolution. 35, 1, p. 107-118 12 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)
56 Citations (Scopus)

Genomic analysis of isolates from the United Kingdom 2012 pertussis outbreak reveals that vaccine antigen genes are unusually fast evolving

Sealey, K. L., Harris, S. R., Fry, N. K., Hurst, L. D., Gorringe, A. R., Parkhill, J. & Preston, A., 15 Jul 2015, In : Journal of Infectious Diseases. 212, 2, p. 294-301 8 p.

Research output: Contribution to journalArticle

Open Access
File
42 Citations (Scopus)
132 Downloads (Pure)

Great majority of recombination events in Arabidopsis are gene conversion events

Yang, S., Yuan, Y., Wang, L., Li, J., Wang, W., Liu, H., Chen, J., Hurst, L. D. & Tian, D., 18 Dec 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 51, p. 20992-20997 6 p.

Research output: Contribution to journalArticle

Open Access
File
50 Citations (Scopus)
92 Downloads (Pure)

Human evolution is still happening – possibly faster than ever

Hurst, L. D., 14 Nov 2018, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access
Open Access
File
9 Citations (Scopus)
34 Downloads (Pure)

In eubacteria, unlike eukaryotes, there is no evidence for selection favouring fail-safe 3' additional stop codons

Ho, A. T. & Hurst, L. D., 17 Sep 2019, In : Plos Genetics. 15, 9, p. 1-32 32 p., e1008386.

Research output: Contribution to journalArticle

Open Access

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression

Wang, J., Singh, M., Sun, C., Besser, D., Prigione, A., Ivics, Z., Hurst, L. D. & Izsvák, Z., 1 Feb 2016, In : Nature Protocols. 11, 2, p. 327-346 20 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
4 Citations (Scopus)

Late-replicating domains have higher divergence and diversity in Drosophila melanogaster

Weber, C. C., Pink, C. J. & Hurst, L. D., Feb 2012, In : Molecular Biology and Evolution. 29, 2, p. 873-882 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Male Mutation Bias Is the Main Force Shaping Chromosomal Substitution Rates in Monotreme Mammals

Link, V., Aguilar-Gómez, D., Ramírez-Suástegui, C., Hurst, L. D. & Cortez, D., 1 Sep 2017, In : Genome biology and evolution. 9, 9, p. 2198-2210 13 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Metabolic trade-offs and the maintenance of the fittest and the flattest

Beardmore, R. E., Gudelj, I., Lipson, D. A. & Hurst, L. D., 21 Apr 2011, In : Nature. 472, 7343, p. 342-346 5 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Molecular genetics: The sound of silence

Hurst, L. D., 31 Mar 2011, In : Nature. 471, 7340, p. 582-583 2 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Mutation rate analysis via parent– progeny sequencing of the perennial peach. I. A low rate in woody perennials and a higher mutagenicity in hybrids

Xie, Z., Wang, L., Wang, L., Wang, Z., Lu, Z., Tian, D., Yang, S. & Hurst, L. D., 26 Oct 2016, In : Proceedings of the Royal Society B: Biological Sciences. 283, 1841, 20161016.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
112 Downloads (Pure)

Mutation rate analysis via parent- progeny sequencing of the perennial peach. II. No evidence for recombination associated mutation

Wang, L., Zhang, Y., Qin, C., Tian, D., Yang, S. & Hurst, L. D., 26 Oct 2016, In : Proceedings of the Royal Society B: Biological Sciences. 283, 1841, 20161785.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
120 Downloads (Pure)

Neighboring genes show correlated evolution in gene expression

Ghanbarian, A. T. & Hurst, L. D., Jul 2015, In : Molecular Biology and Evolution. 32, 7, p. 1748-1766

Research output: Contribution to journalArticle

48 Citations (Scopus)

Open questions: A logic (or lack thereof) of genome organization

Hurst, L. D., 28 May 2013, In : BMC Biology. 11, 58.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Parent-progeny sequencing indicates higher mutation rates in heterozygotes

Yang, S., Wang, L., Huang, J., Zhang, X., Yuan, Y., Chen, J. Q., Hurst, L. D. & Tian, D., 23 Jul 2015, In : Nature. 523, 7561, p. 463-467 5 p.

Research output: Contribution to journalArticle

Open Access
File
67 Citations (Scopus)
189 Downloads (Pure)

Pluripotency and the endogenous retrovirus HERVH: conflict or serendipity?

Izsvák, Z., Wang, J., Singh, M., Mager, D. L. & Hurst, L. D., 1 Jan 2016, In : Bioessays. 38, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Positive charge loading at protein termini is due to membrane protein topology, not a translational ramp

Charneski, C. A. & Hurst, L. D., Jan 2014, In : Molecular Biology and Evolution. 31, 1, p. 70-84 15 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
136 Downloads (Pure)

Positively charged residues are the major determinants of ribosomal velocity

Charneski, C. A. & Hurst, L. D., 12 Mar 2013, In : PLoS Biology. 11, 3, e1001508.

Research output: Contribution to journalArticle

139 Citations (Scopus)