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  • Richard Guy

AFM nanotools for surgery of biological Cells

Beard, J. D., Gordeev, S. N. & Guy, R. H., 2011, In : Journal of Physics: Conference Series. 286, 1, 012003.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access
File
29 Citations (Scopus)
186 Downloads (Pure)

Assessing the safety of cosmetic chemicals: consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern)

Williams, F. M., Rothe, H., Barrett, G., Chiodini, A., Whyte, J., Cronin, M. T. D., Monteiro-Riviere, N. A., Plautz, J., Roper, C., Westerhout, J., Yang, C. & Guy, R. H., 1 Apr 2016, In : Regulatory Toxicology and Pharmacology. 76, p. 174-186 13 p.

Research output: Contribution to journalArticle

Open Access
26 Citations (Scopus)

Assessment of dermal exposure to pesticide residues during re-entry

Belsey, N. A., Cordery, S. F., Bunge, A. L. & Guy, R. H., 15 May 2011, In : Environmental Science & Technology. 45, 10, p. 4609-4615 7 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
141 Downloads (Pure)

Bioequivalence methodologies for topical drug products: in vitro and ex vivo studies with a cortiscosteroid and an anti-fungal drug

Bastos Leal, L., Cordery, S. F., Delgado-Charro, M. B., Bunge, A. L. & Guy, R. H., Apr 2017, In : Pharmaceutical Research. 34, 4, p. 730-737 8 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Biophysical elucidation of the mechanism of enhanced drug release and topical delivery from polymeric film-forming systems

Garvie-Cook, H., Frederiksen, K., Petersson, K., Guy, R. & Gordeev, S., 28 Aug 2015, In : Journal of Controlled Release. 212, p. 103-112 10 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
148 Downloads (Pure)
Open Access
File
32 Citations (Scopus)
164 Downloads (Pure)

Characterisation of skin barrier function using bioengineering and biophysical techniques

Yang, Q. & Guy, R. H., 5 Aug 2014, In : Pharmaceutical Research. 32, 2, p. 445-457

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
162 Downloads (Pure)

Characterization of Topical Film-Forming Systems Using Atomic Force Microscopy and Raman Microspectroscopy

Garvie-cook, H., Frederiksen, K., Petersson, K., Guy, R. H. & Gordeev, S., Mar 2015, In : Molecular Pharmaceutics. 12, 3, p. 751-757 7 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
148 Downloads (Pure)

Choice of moisturiser for eczema treatment (COMET): feasibility study of a randomised controlled parallel group trial in children recruited from primary care

Ridd, M., Garfield, K., Gaunt, D., Hollinghurst, S., Redmond, N., Powell, K., Wilson, V., Guy, R., Ball, N., Shaw, L., Purdy, S. & Metcalfe, C., 16 Nov 2016, In : BMJ Open. 6, 11, 9 p., e012021.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Choice of Moisturiser for Eczema Treatment (COMET): Study protocol for a randomized controlled trial

Ridd, M. J., Redmond, N. M., Hollinghurst, S., Ball, N., Shaw, L., Guy, R., Wilson, V., Metcalfe, C. & Purdy, S., 15 Jul 2015, In : Trials. 16, 304.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
96 Downloads (Pure)

Comparison of gravimetric and spectroscopic approaches to quantify stratum corneum removed by tape-stripping

Mohammed, D., Yang, Q., Guy, R. H., Matts, P. J., Hadgraft, J. & Lane, M. E., Sep 2012, In : European Journal of Pharmaceutics and Biopharmaceutics. 82, 1, p. 171-174

Research output: Contribution to journalArticle

32 Citations (Scopus)

Comparison of patient (POEM), observer (EASI, SASSAD, TIS) and corneometry measures of emollient effectiveness in children with eczema: findings from the COMET feasibility trial

Ridd, M. J., Gaunt, D. M., Guy, R. H., Redmond, N. M., Garfield, K., Hollinghurst, S., Ball, N., Shaw, L., Purdy, S. & Metcalfe, C., 1 Aug 2018, In : British Journal of Dermatology. 179, 2, p. 362-370 9 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
38 Downloads (Pure)

Dermal Absorption of Pesticide Residues

Clarke, J., Cordery, S., Morgan, N. A., Knowles, P. & Guy, R., 17 Dec 2018, In : Chemical Research in Toxicology. 31, 12, p. 1356-1363

Research output: Contribution to journalArticle

File
1 Citation (Scopus)
37 Downloads (Pure)

Development and in vitro evaluation of lipid nanoparticle-based dressings for topical treatment of chronic wounds

Gainza, G., Chu, W. S., Guy, R. H., Pedraz, J. L., Hernandez, R. M., Delgado-Charro, B. & Igartua, M., 25 Jul 2015, In : International Journal of Pharmaceutics. 490, 1-2, p. 404-411 8 p.

Research output: Contribution to journalArticle

File
19 Citations (Scopus)
143 Downloads (Pure)

Drug delivery into microneedle-porated nails from nanoparticle reservoirs

Chiu, W. S., Belsey, N. A., Garrett, N. L., Moger, J., Price, G. J., Delgado-Charro, M. B. & Guy, R. H., 28 Dec 2015, In : Journal of Controlled Release. 220, A, p. 98-106 9 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
131 Downloads (Pure)

Effective use of transdermal drug delivery in children

Delgado-Charro, M. B. & Guy, R. H., 30 Jun 2014, In : Advanced Drug Delivery Reviews. 73, p. 63-82

Research output: Contribution to journalReview article

File
46 Citations (Scopus)
212 Downloads (Pure)
Open Access
File
9 Citations (Scopus)
142 Downloads (Pure)

Evaluation of drug delivery to intact and porated skin by coherent Raman scattering and fluorescence microscopies

Belsey, N. A., Garrett, N. L., Contreras-Rojas, L. R., Pickup-Gerlaugh, A. J., Price, G. J., Moger, J. & Guy, R. H., 28 Jan 2014, In : Journal of Controlled Release. 174, 28, p. 37-42 6 p.

Research output: Contribution to journalArticle

Open Access
File
42 Citations (Scopus)
211 Downloads (Pure)

Femtosecond pulsed laser ablation to enhance drug delivery across the skin

Garvie-Cook, H., Stone, J. M., Yu, F., Guy, R. H. & Gordeev, S. N., 5 Jan 2016, In : Journal of Biophotonics. 9, 1-2, p. 144-154 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
Open Access
File
31 Citations (Scopus)
231 Downloads (Pure)
Open Access
File
10 Citations (Scopus)
204 Downloads (Pure)

Imaging drug delivery to skin with coherent raman scattering microscopy

Belsey, N. A., Contreras-Rojas, L. R. & Guy, R. H., 1 Jan 2014, Non Invasive Diagnostic Techniques in Clinical Dermatology. Springer Berlin Heidelberg, p. 225-231 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Imaging drug delivery to skin with stimulated Raman scattering microscopy

Saar, B. G., Contreras-Rojas, L. R., Xie, X. S. & Guy, R. H., 6 Jun 2011, In : Molecular Pharmaceutics. 8, 3, p. 969-975 7 p.

Research output: Contribution to journalArticle

Open Access
File
113 Citations (Scopus)
160 Downloads (Pure)

In situ detection of salicylate in Ocimum basilicum plant leaves via reverse iontophoresis

González-Sánchez, M. I., Lee, P. T., Guy, R. H. & Compton, R. G., 28 Nov 2015, In : Chemical Communications. 51, 92, p. 16534-16536 3 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
134 Downloads (Pure)

In vitro method to quantify dermal absorption of pesticide residues

Clarke, J. F., Cordery, S. F., Morgan, N. A., Knowles, P. K. & Guy, R. H., 16 Feb 2015, In : Chemical Research in Toxicology. 28, 2, p. 166-168

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
135 Downloads (Pure)

Iontophoresis of minoxidil sulphate loaded microparticles, a strategy for follicular drug targeting?

Gelfuso, G. M., Barros, M. A. D. O., Delgado-Charro, M. B., Guy, R. H. & Lopez, R. F. V., Oct 2015, In : Colloids and Surfaces B: Biointerfaces. 134, p. 408-412 5 p.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
155 Downloads (Pure)

Iontophoresis-targeted, follicular delivery of minoxidil sulfate for the treatment of alopecia

Gelfuso, G. M., Gratieri, T., Delgado-Charro, M. B., Guy, R. H. & Vianna Lopez, R. F., 1 May 2013, In : Journal of Pharmaceutical Sciences. 102, 5, p. 1488-1494

Research output: Contribution to journalArticle

24 Citations (Scopus)

Iontophoretic transdermal sampling of iohexol as a noninvasive tool to assess glomerular filtration rate

Djabri, A., van’t Hoff, W., Brock, P., Wong, I. C. K., Guy, R. & Delgado-Charro, B., 1 Feb 2015, In : Pharmaceutical Research. 32, 2, p. 590-603 14 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
137 Downloads (Pure)

Managing diabetes through the skin: Diagnostic devices

Guy, R., Jun 2016, In : Nature Nanotechnology. 11, 6, p. 493-494 2 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
166 Downloads (Pure)

Mathematical models of skin permeability: An overview

Mitragotri, S., Anissimov, Y. G., Bunge, A. L., Frasch, H. F., Guy, R. H., Hadgraft, J., Kasting, G. B., Lane, M. E. & Roberts, M. S., 10 Oct 2011, In : International Journal of Pharmaceutics. 418, 1, p. 115-129 15 p.

Research output: Contribution to journalArticle

Open Access
File
175 Citations (Scopus)
264 Downloads (Pure)

Mechanical tomography of human corneocytes with a nanoneedle

Beard, J. D., Guy, R. H. & Gordeev, S. N., Jun 2013, In : Journal Of Investigative Dermatology. 133, 6, p. 1565-1571 7 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
117 Downloads (Pure)

Mechanism of human nail poration by high-repetition-rate, femtosecond laser ablation

Vanstone, S., Stone, J., Gordeev, S. & Guy, R., 31 Oct 2019, In : Drug Delivery and Translational Research. 9, 5, p. 956–967 12 p.

Research output: Contribution to journalArticle

Open Access

Metals and the skin: Topical effects and systemic absorption

Guy, R. H., Hostýnek, J. J., Hinz, R. S. & Lorence, C. R., 19 Apr 2016, CRC Press. 431 p.

Research output: Book/ReportBook

4 Citations (Scopus)

Method for non-invasively determining the relative levels of two biological substances. B1

Delgado-Charro, M. & Guy, R., 10 Oct 2012, IPC No. A61N1/30; (IPC1-7): A61N1/30, Patent No. EP1401532 (WO03000340), 17 Jun 2002, Priority date 22 Jun 2001, Priority No. 0114750.1 20010622 ; WO2002EP06637 20020617 ; EP20020747396 20020617

Research output: Patent

Method for non-invasively determining the relative levels of two biological substances. T3

Delgado-Charro, M. & Guy, R., 4 Feb 2013, Patent No. ES2394691T, Priority date 22 Jun 2001, Priority No. EP01114750

Research output: Patent

Modelling drug flux through microporated skin

Rzhevskiy, A. S., Guy, R. H. & Anissimov, Y. G., 10 Nov 2016, In : Journal of Controlled Release. 241, p. 194-199 6 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
134 Downloads (Pure)

Molecular diffusion in the human nail measured by stimulated Raman scattering microscopy

Chiu, W-S., Belsey, N., Garrett, N. L., Moger, J., Delgado-Charro, M. & Guy, R., 23 Jun 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 25, p. 7725-7730 6 p.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
156 Downloads (Pure)

Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform

Lipani, L., Dupont, B. G. R., Doungmene, F., Marken, F., Tyrrell, R. M., Guy, R. H. & Ilie, A., 30 Jun 2018, In : Nature Nanotechnology. 13, 6, p. 504-511 8 p.

Research output: Contribution to journalArticle

Open Access
File
63 Citations (Scopus)
523 Downloads (Pure)

Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies

Russell, L. M. & Guy, R. H., Sep 2012, In : Pharmaceutical Research. 29, 9, p. 2389-2397 9 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
127 Downloads (Pure)

Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies: Proof-of-concept with acyclovir formulations

Russell, L. M. & Guy, R. H., Dec 2012, In : Pharmaceutical Research. 29, 12, p. 3362-3372 11 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
120 Downloads (Pure)

Objective assessment of nanoparticle disposition in mammalian skin after topical exposure

Campbell, C. S. J., Contreras-Rojas, L. R., Delgado-Charro, B. & Guy, R. H., 20 Aug 2012, In : Journal of Controlled Release. 162, 1, p. 201-207 7 p.

Research output: Contribution to journalArticle

Open Access
File
83 Citations (Scopus)
395 Downloads (Pure)

Optimisation of Cosolvent Concentration for Topical Drug Delivery III - Influence of Lipophilic Vehicles on Ibuprofen Permeation

Watkinson, R. M., Guy, R. H., Oliveira, G., Hadgraft, J. & Lane, M. E., 2011, In : Skin Pharmacology and Physiology. 24, 1, p. 22-26 5 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
Open Access
File
17 Citations (Scopus)
142 Downloads (Pure)
File
5 Citations (Scopus)
140 Downloads (Pure)

Potential of iontophoresis as a drug delivery method for midazolam in pediatrics

Djabri, A., Guy, R. & Delgado-Charro, M., 1 Feb 2019, In : European Journal of Pharmaceutical Sciences. 128, p. 137-143 7 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
25 Downloads (Pure)

Precise laser poration to control drug delivery into and through human nail

Vanstone, S., Cordery, S., Stone, J., Gordeev, S. & Guy, R., 28 Dec 2017, In : Journal of Controlled Release. 268, p. 72-77 6 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
156 Downloads (Pure)

Products in "Bounty bags" potentially harm newborn skin

Ridd, M., Guy, R., Ball, N., Roberts, A. & Williams, H., 22 Jun 2013, In : BMJ . 346, 7913, f3895.

Research output: Contribution to journalArticle

Regulatory Science and Innovation Programme for Europe (ReScIPE): A proposed model

Hines, P. A., Guy, R. H., Brand, A., Humphreys, A. J. & Papaluca-Amati, M., 19 Aug 2019, In : British Journal Of Clinical Pharmacology. p. 1-6 6 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
21 Downloads (Pure)

Reverse iontophoretic extraction of metabolites from living plants and their identification by ion-chromatography coupled to high resolution mass spectrometry

Gonzalez-Sanchez, M. I., McCullagh, J., Guy, R. & Compton, R., May 2017, In : Phytochemical Analysis. 28, 3, p. 195-201 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)