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Author

  • Barry Potter
2013

Regioselective opening of myo-inositol orthoesters: Mechanism and synthetic utility

Godage, H. Y., Riley, A. M., Woodman, T. J., Thomas, M. P., Mahon, M. F. & Potter, B. V. L., 15 Mar 2013, In : Journal of Organic Chemistry. 78, 6, p. 2275-2288

Research output: Contribution to journalArticle

9 Citations (Scopus)
2015

Estrogen O-sulfamates and their analogues: clinical steroid sulfatase inhibitors with broad potential

Thomas, M. P. & Potter, B. V. L., 1 Sep 2015, In : Journal of Steroid Biochemistry and Molecular Biology. 153, p. 160-169 10 p., 4391.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2014

The enzymes of human diphosphoinositol polyphosphate metabolism

Thomas, M. P. & Potter, B. V. L., Jan 2014, In : FEBS Journal. 281, 1, p. 14-33 20 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2013

Inframolecular acid-base and coordination properties towards Na+ and Mg2+ of myo-inositol 1,3,4,5,6-pentakisphosphate: A structural approach to biologically relevant species

Veiga, N., Torres, J., Macho, I., Gómez, K., Godage, H. Y., Riley, A. M., Potter, B. V. L., González, G. & Kremer, C., 7 May 2013, In : Dalton Transactions. 42, 17, p. 6021-6032

Research output: Contribution to journalArticle

6 Citations (Scopus)
2012

Antagonism of NAADP mediated calcium signaling ameliorates arrythmias in the heart

Nebel, M., Schworer, A., Siebrands, C. C., Limbrock, A-C., Swarbrick, J. M., Hohenegger, M., Geisler, A., Herich, L., Schlegel, S., Carrier, L., Eschenhagen, T., Potter, B. V. L., Ehmke, H. & Guse, A. H., 2012, (Acceptance date) In : Circulation.

Research output: Contribution to journalArticle

2015

The in vitro and in vivo activity of the microtubule disruptor STX140 is mediated by Hif-1 alpha and CAIX expression

Stengel, C., Newman, S. P., Leese, M. P., Thomas, M. P., Potter, B. V. L., Reed, M. J., Purohit, A. & Foster, P. A., 1 Oct 2015, In : Anticancer Research. 35, 10, p. 5249-5262 14 p.

Research output: Contribution to journalArticle

2013

Stimulation of Inositol 1,4,5-Trisphosphate (IP3) Receptor Subtypes by Analogues of IP3

Saleem, H., Tovey, S. C., Rahman, T., Riley, A. M., Potter, B. V. L. & Taylor, C. W., 30 Jan 2013, In : PLoS ONE. 8, 1, 54877.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2015

Calcium Signalling Triggered by NAADP in T Cells Determines Cell Shape and Motility During Immune Synapse Formation

Nebel, M., Zhang, B., Odoardi, F., Flugel, A., Potter, B. & Guse, A. H., 2015, In : Messenger. 4, 1, p. 104-111

Research output: Contribution to journalArticle

Open Access
File
121 Downloads (Pure)
2014

Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response

Pulloor, N. K., Nair, S., Kostic, A. D., Bist, P., Weaver, J. D., Riley, A. M., Tyagi, R., Uchil, P. D., York, J. D., Snyder, S. H., García-Sastre, A., Potter, B. V. L., Lin, R., Shears, S. B., Xavier, R. J. & Krishnan, M. N., 27 Feb 2014, In : PLoS Pathogens. 10, 2, e1003981.

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)
2013

Synthesis and structure-activity relationship studies of derivatives of the dual aromatase-sulfatase inhibitor 4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

Woo, L. W. L., Wood, P. M., Bubert, C., Thomas, M. P., Purohit, A. & Potter, B. V. L., May 2013, In : ChemMedChem. 8, 5, p. 779-799 21 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2011

The effects of paclitaxel and STX140 on early-and late-stage breast cancer in tte clinically relevant C3(1)/SV40 mouse model

Newman, S. P., Day, J. M., Potter, B. V. L., Reed, M. J. & Purohit, A., 2011, (Acceptance date) In : European Journal of Cancer.

Research output: Contribution to journalArticle

2012

A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery

Mills, S. J., Persson, C., Cozier, G., Thomas, M. P., Trésaugues, L., Erneux, C., Riley, A. M., Nordlund, P. & Potter, B. V. L., 18 May 2012, In : ACS Chemical Biology. 7, 5, p. 822-828

Research output: Contribution to journalArticle

24 Citations (Scopus)

Fibrinogen—a possible extracellular target for inositol phosphates

Grint, T., Riley, A. M., Mills, S. J., Potter, B. V. L. & Safrany, S. T., 1 Dec 2012, In : Messenger. 1, 2, p. 160-166

Research output: Contribution to journalArticle

Steroidomimetic tetrahydroisoquinolines for the design of new microtubule disruptors

Leese, M. P., Jourdan, F., Dohle, W., Kimberley, M. R., Thomas, M. P., Bai, R., Hamel, E., Ferrandis, E. & Potter, B. V. L., 2012, In : ACS Medicinal Chemistry Letters. 3, 1, p. 5-9

Research output: Contribution to journalArticle

27 Citations (Scopus)
2018

Quinazolinone-based Anticancer Agents: Synthesis, Anti-proliferative SAR, Anti-tubulin Activity and Tubulin Co-crystal Structure

Dohle, W., Jourdan, F., Menchon, G., Prota, A., Foster, P. A., Mannion, P., Hamel, E., Thomas, M., Kasprzyk, P. G., Ferrandis, E., Steinmetz, M. O., Leese, M. & Potter, B., 2018, (Unpublished) In : Journal of Medicinal Chemistry. 49 p.

Research output: Contribution to journalArticle

2017

Ligand induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg 1433 and Tyr 1349

Fliegert, R., Watt, J. M., Schöbel, A., Rozewitz, M. D., Moreau, C., Kirchberger, T., Thomas, M. P., Sick, W., Araujo, A. C., Harneit, A., Potter, B. V. L. & Guse, A. H., 16 Jun 2017, In : Biochemical Journal. 474, 13, p. 2159-2175 BCJ20170091.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)
2014

Synthesis, Antitubulin, and Antiproliferative SAR of C3/C1-Substituted Tetrahydroisoquinolines

Dohle, W., Leese, M. P., Jourdan, F. L., Major, M. R., Bai, R., Hamel, E., Ferrandis, E., Kasprzyk, P. G., Fiore, A., Newman, S. P., Purohit, A. & Potter, B. V. L., Feb 2014, In : ChemMedChem. 9, 2, p. 350-370

Research output: Contribution to journalArticle

12 Citations (Scopus)
2015

Designer small molecules to target calcium signalling

Swarbrick, J. M., Riley, A. M., Mills, S. J. & Potter, B. V. L., 1 Jun 2015, In : Biochemical Society Transactions. 43, 3, p. 417-425 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2011

Crystal structures of II beta-hydroxysteroid dehydrogenase type I and their use in drug discovery

Thomas, M. P. & Potter, B. V. L., Mar 2011, In : Future Medicinal Chemistry. 3, 3, p. 367-390

Research output: Contribution to journalArticle

22 Citations (Scopus)
2015

Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol

Shen, Y. C., Upadhyayula, R., Cevallos, S., Messick, R. J., Hsia, T., Leese, M. P., Jewett, D. M., Ferrer-Torres, D., Roth, T. M., Dohle, W., Potter, B. V. L. & Barald, K. F., 20 Oct 2015, In : British Journal of Cancer. 113, 8, p. 1158-1167 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2013

Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by Adenophostin A and its analogues

Saleem, H., Tovey, S. C., Riley, A. M., Potter, B. V. L. & Taylor, C. W., 28 Feb 2013, In : PLoS ONE. 8, 2, e58027.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
85 Downloads (Pure)
2014

Optimisation of tetrahydroisoquinoline-based chimeric microtubule disruptors

Dohle, W., Leese, M. P., Jourdan, F. L., Chapman, C. J., Hamel, E., Ferrandis, E. & Potter, B. V. L., Aug 2014, In : ChemMedChem. 9, 8, p. 1783-1793 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2011

Steroid sulfatase: a pivotal player in estrogen synthesis and metabolism

Purohit, A., Woo, L. W. L. & Potter, B. V. L., 4 Jul 2011, In : Molecular and Cellular Endocrinology. 340, 2, p. 154-160

Research output: Contribution to journalArticle

Open Access
File
49 Citations (Scopus)
166 Downloads (Pure)
2014

'Click cyclic ADP-ribose': A neutral second messenger mimic

Swarbrick, J. M., Graeff, R., Garnham, C., Thomas, M. P., Galione, A. & Potter, B. V. L., 7 Mar 2014, In : Chemical Communications. 50, 19, p. 2458-2461 4 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
105 Downloads (Pure)
2017

Simple synthesis of 32P-labelled inositol hexakisphosphates for study of phosphate transformations

Whitfield, H., Riley, A. M., Diogenous, S., Godage, H. Y., Potter, B. & Brearley, C. A., 27 Jun 2017, In : Plant and Soil.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2011

Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11 beta-hydroxysteroid dehydrogenase type 1

Su, X., Pradaux-Caggiano, F., Vicker, N., Thomas, M. P., Halem, H., Culler, M. D. & Potter, B. V. L., 5 Sep 2011, In : ChemMedChem. 6, 9, p. 1616-1629

Research output: Contribution to journalArticle

10 Citations (Scopus)
2017

SHIP2: structure, function and inhibition

Thomas, M. P., Erneux, C. & Potter, B. V. L., 1 Feb 2017, In : ChemBiochem. 18, 3, p. 233-247

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
268 Downloads (Pure)
2013

Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger

Tsuzuki, T., Sakaguchi, N., Kudoh, T., Takano, S., Uehara, M., Murayama, T., Sakurai, T., Hashii, M., Higashida, H., Weber, K., Guse, A. H., Kameda, T., Hirokawa, T., Kumaki, Y., Potter, B. V. L., Fukuda, H., Arisawa, M. & Shuto, S., 24 Jun 2013, In : Angewandte Chemie-International Edition. 52, 26, p. 6633-6637

Research output: Contribution to journalArticle

13 Citations (Scopus)
2012

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase

Riley, A. M., Wang, H., Weaver, J. D., Shears, S. B. & Potter, B. V. L., 24 Oct 2012, In : Chemical Communications. 48, 92, p. 11292-11294 3 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2018

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers

Watt, J. M., Thomas, M. & Potter, B., 15 Oct 2018, In : Scientific Reports. 8, 15268.

Research output: Contribution to journalArticle

Open Access
2017

Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5'-diphosphate ribose”

Watt, J. M., Graeff, R., Thomas, M. P. & Potter, B., 23 Nov 2017, In : Scientific Reports. 7, 16100.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
36 Downloads (Pure)
2020

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5'-diphosphate ribose (ADPR)

Potter, B., Watt, J. M. & Baszczynski, O., 2020, In : RSC Advances. 10, 3, p. 1776-1785

Research output: Contribution to journalArticle

Open Access
2018

Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease

Zhang, B., Watt, J. M., Cordiglieri, C., Dammermann, W., Mahon, M., Flugel, A., Guse, A. H. & Potter, B., 13 Nov 2018, In : Scientific Reports. 8, 17 p., 16775.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2014

Cellular internalisation of an inositol phosphate visualised by using fluorescent InsP5

Riley, A. M., Windhorst, S., Lin, H-Y. & Potter, B. V. L., 3 Jan 2014, In : ChemBiochem. 15, 1, p. 57-67 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2017
Open Access
3 Citations (Scopus)
2011

Development of steroid sulfatase inhibitors

Woo, L. W. L., Purohit, A. & Potter, B. V. L., 4 Jul 2011, In : Molecular and Cellular Endocrinology. 340, 2, p. 175-185

Research output: Contribution to journalArticle

Open Access
File
42 Citations (Scopus)
155 Downloads (Pure)
2018

A Fluorescent Probe Identifies Active Site Ligands of Inositol Pentakisphosphate 2-Kinase

Potter, B. & Godage, H., 11 Oct 2018, In : Journal of Medicinal Chemistry. 61, 19, p. 8838-8846 9 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
35 Downloads (Pure)
2014

Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery

Wang, H., Godage, H. Y., Riley, A. M., Weaver, J. D., Shears, S. B. & Potter, B. V. L., 22 May 2014, In : Chemistry & Biology. 21, 5, p. 689-699 11 p.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)
2011

Hybrid dual aromatase-steroid sulfatase inhibitors with exquisite picomolar inhibitory activity

Woo, L. W. L., Bubert, C., Purohit, A. & Potter, B. V. L., Mar 2011, In : ACS Medicinal Chemistry Letters. 2, 3, p. 243-247

Research output: Contribution to journalArticle

27 Citations (Scopus)
2013

Subtype-selective regulation of IP3 receptors by thimerosal via cysteine residues within the IP3-binding core and suppressor domain

Khan, S. A., Rossi, A. M., Riley, A. M., Potter, B. V. L. & Taylor, C. W., 15 Apr 2013, In : Biochemical Journal. 451, 2, p. 177-184

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
110 Downloads (Pure)
2014

Synthetic inositol phosphate analogues in complex with PPIP5K2 uncover a substrate capture site as a target for drug discovery

Wang, H., Godage, H., Riley, A., Weaver, J. D., Potter, B. & Shears, S. B., 2014, In : Chemistry & Biology.

Research output: Contribution to journalArticle

2018

Steroid sulphatase inhibition via aryl sulphamates: Clinical progress, mechanism and future prospects

Potter, B. V. L., 1 Aug 2018, In : Journal of Molecular Endocrinology. 61, 2, p. T233-T252 20 p.

Research output: Contribution to journalReview article

Open Access
20 Citations (Scopus)
2013

Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation

Nebel, M., Schwoerer, A. P., Warszta, D., Siebrands, C. C., Limbrock, A-C., Swarbrick, J. M., Fliegert, R., Weber, K., Bruhn, S., Hohenegger, M., Geisler, A., Herich, L., Schlegel, S., Carrier, L., Eschenhagen, T., Potter, B. V. L., Ehmke, H. & Guse, A. H., 31 May 2013, In : Journal of Biological Chemistry. 288, 22, p. 16017-16030

Research output: Contribution to journalArticle

22 Citations (Scopus)

CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5′-Diphosphate Ribose Template

Moreau, C., Liu, Q., Graeff, R., Wagner, G. K., Thomas, M. P., Swarbrick, J. M., Shuto, S., Lee, H. C., Hao, Q. & Potter, B. V. L., 19 Jun 2013, In : PLoS ONE. 8, 6, 15 p., e66247.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
134 Downloads (Pure)
2014

Cyclic adenosine 5′-diphosphate ribose analogs without a southern ribose inhibit ADP-ribosyl cyclase-hydrolase CD38

Swarbrick, J. M., Graeff, R., Zhang, H., Thomas, M. P., Hao, Q. & Potter, B. V. L., 23 Oct 2014, In : Journal of Medicinal Chemistry. 57, 20, p. 8517-8529 13 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
91 Downloads (Pure)
2016

A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion

Raimondi, C., Calleja, V., Ferro, R., Fantin, A., Riley, A. M., Potter, B. V. L., Brennan, C. H., Maffucci, T., Larijani, B. & Falasca, M., 20 May 2016, In : Scientific Reports. 6, 26142.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
85 Downloads (Pure)
2014

16- AND 17- DEUTERATED ESTROGEN-3-SULFAMATES AS ESTROGENIC AGENTS

Potter, B., 14 Aug 2014, IPC No. A61K31/565; A61P5/30; C07J41/00;, Patent No. WO2014122480A1, 10 Feb 2014, Priority date 11 Feb 2013, Priority No. 1302368.4

Research output: Patent

2011

Synthesis of cyclic adenosine 5 '-diphosphate ribose analogues: a C2 ' endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor

Moreau, C., Ashamu, G. A., Bailey, V. C., Galione, A., Guse, A. H. & Potter, B. V. L., 2011, In : Organic and Biomolecular Chemistry. 9, 1, p. 278-290

Research output: Contribution to journalArticle

17 Citations (Scopus)
2014

Tetrahydroisoquinolinone-based steroidomimetic and chimeric microtubule disruptors

Leese, M. P., Jourdan, F. L., Major, M. R., Dohle, W., Hamel, E., Ferrandis, E., Fiore, A., Kasprzyk, P. G. & Potter, B. V. L., Jan 2014, In : ChemMedChem. 9, 1, p. 85-108 24 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2015

Designer small molecules to target calcium signalling

Swarbrick, J., Riley, A., Mills, S. & Potter, B., 2015.

Research output: Contribution to conferencePaper

File
4 Citations (Scopus)
120 Downloads (Pure)