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Author

  • Laurence Hurst
2016

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression

Wang, J., Singh, M., Sun, C., Besser, D., Prigione, A., Ivics, Z., Hurst, L. D. & Izsvák, Z., 1 Feb 2016, In : Nature Protocols. 11, 2, p. 327-346 20 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2011
4 Citations (Scopus)
2017

Male Mutation Bias Is the Main Force Shaping Chromosomal Substitution Rates in Monotreme Mammals

Link, V., Aguilar-Gómez, D., Ramírez-Suástegui, C., Hurst, L. D. & Cortez, D., 1 Sep 2017, In : Genome biology and evolution. 9, 9, p. 2198-2210 13 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

The best way to get children to understand evolution is to teach genetics first, finds study

Hurst, L., Hejmadi, M. & Mead, R., 23 May 2017, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access
2014

Purifying selection on splice-related motifs, not expression level nor RNA folding, explains nearly all constraint on human lincRNAs

Schüler, A., Ghanbarian, A. T. & Hurst, L. D., 1 Dec 2014, In : Molecular Biology and Evolution. 31, 12, p. 3164-3183 20 p.

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)
2011

Birt Hogg-Dube Syndrome-Associated FLCN Mutations Disrupt Protein Stability

Nahorski, M. S., Reiman, A., Lim, D. H. K., Nookala, R. K., Seabra, L., Lu, X. H., Fenton, J., Boora, U., Nordenskjold, M., Latif, F., Hurst, L. D. & Maher, E. R., Aug 2011, In : Human Mutation. 32, 8, p. 921-929 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Metabolic trade-offs and the maintenance of the fittest and the flattest

Beardmore, R. E., Gudelj, I., Lipson, D. A. & Hurst, L. D., 21 Apr 2011, In : Nature. 472, 7343, p. 342-346 5 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2013

Positively charged residues are the major determinants of ribosomal velocity

Charneski, C. A. & Hurst, L. D., 12 Mar 2013, In : PLoS Biology. 11, 3, e1001508.

Research output: Contribution to journalArticle

141 Citations (Scopus)
2019

In eubacteria, unlike eukaryotes, there is no evidence for selection favouring fail-safe 3' additional stop codons

Ho, A. T. & Hurst, L. D., 17 Sep 2019, In : Plos Genetics. 15, 9, p. 1-32 32 p., e1008386.

Research output: Contribution to journalArticle

Open Access
2016

Why is the X chromosome so odd? Traffic analogy helped us crack the mystery

Hurst, L. D. & Huminiecki, L., 11 Jan 2016, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access
2014

Predicting the virulence of MRSA from its genome sequence

Laabei, M., Recker, M., Rudkin, J. K., Aldeljawi, M., Gulay, Z., Sloan, T. J., Williams, P., Endres, J. L., Bayles, K. W., Fey, P. D., Yajjala, V. K., Widhelm, T., Hawkins, E., Lewis, K., Parfett, S., Scowen, L., Peacock, S. J., Holden, M., Wilson, D., Read, T. D. & 6 others, Van Den Elsen, J., Priest, N. K., Feil, E. J., Hurst, L. D., Josefsson, E. & Massey, R. C., 1 May 2014, In : Genome Research. 24, 5, p. 839-849 11 p.

Research output: Contribution to journalArticle

Open Access
83 Citations (Scopus)
59 Downloads (Pure)
2018

Human evolution is still happening – possibly faster than ever

Hurst, L. D., 14 Nov 2018, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access
2013

Evidence for deep phylogenetic conservation of exonic splice-related constraints: Splice-related skews at exonic ends in the brown alga Ectocarpus are common and resemble those seen in humans

Wu, X., Tronholm, A., Fernandez Cáceres, E., Tovar-Corona, J. M., Chen, L., Urrutia, A. O. & Hurst, L. D., 2013, In : Genome biology and evolution. 5, 9, p. 1731-1745 15 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
125 Downloads (Pure)
2012

Late-replicating domains have higher divergence and diversity in Drosophila melanogaster

Weber, C. C., Pink, C. J. & Hurst, L. D., Feb 2012, In : Molecular Biology and Evolution. 29, 2, p. 873-882 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2016
Open Access
File
23 Citations (Scopus)
129 Downloads (Pure)

Pluripotency and the endogenous retrovirus HERVH: conflict or serendipity?

Izsvák, Z., Wang, J., Singh, M., Mager, D. L. & Hurst, L. D., 1 Jan 2016, In : Bioessays. 38, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2020
Open Access
2019

A century of bias in genetics and evolution

Hurst, L., 12 Jun 2019, In : Heredity. 123, 1, p. 33-43 11 p.

Research output: Contribution to journalReview article

Open Access
File
72 Downloads (Pure)
2015

The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome

the FANTOM consortium & Huminiecki, L., 31 Dec 2015, In : PLoS Biology. 13, 12, p. 1-48 48 p., e1002315.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)
46 Downloads (Pure)
2012

Direct and indirect consequences of meiotic recombination: Implications for genome evolution

Webster, M. T. & Hurst, L. D., Mar 2012, In : Trends in Genetics. 28, 3, p. 101-109 9 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)
2018

Faster Evolving Primate Genes Are More Likely to Duplicate

O'Toole, Á. N., Hurst, L. D. & McLysaght, A., 1 Jan 2018, In : Molecular Biology and Evolution. 35, 1, p. 107-118 12 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)
2015

Neighboring genes show correlated evolution in gene expression

Ghanbarian, A. T. & Hurst, L. D., Jul 2015, In : Molecular Biology and Evolution. 32, 7, p. 1748-1766

Research output: Contribution to journalArticle

50 Citations (Scopus)
2017

Teaching genetics prior to teaching evolution improves evolution understanding but not acceptance

Mead, R., Hejmadi, M. & Hurst, L. D., 31 May 2017, In : PLoS Biology. 15, 5, e2002255.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)
2018

Exonic splice regulation imposes strong selection at synonymous sites

Savisaar, R. & Hurst, L., 1 Oct 2018, In : Genome Research. 28, 10, p. 1442-1454 13 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)
2012

Great majority of recombination events in Arabidopsis are gene conversion events

Yang, S., Yuan, Y., Wang, L., Li, J., Wang, W., Liu, H., Chen, J., Hurst, L. D. & Tian, D., 18 Dec 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 51, p. 20992-20997 6 p.

Research output: Contribution to journalArticle

Open Access
File
52 Citations (Scopus)
96 Downloads (Pure)
2019

The architecture of intra-organism mutation rate variation in plants

Hurst, L., 30 Apr 2019, In : PLoS Biology. 17, 4, 29 p., e3000191.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)
2018

Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica

Mühlhausen, S., Schmitt, H. D., Pan, K. T., Plessmann, U., Urlaub, H., Hurst, L. D. & Kollmar, M., 9 Jul 2018, In : Current Biology. 28, 13, p. 2046-2057 18 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2017

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids

Thumann, G., Harmening, N., Prat-Souteyrand, C., Marie, C., Pastor, M., Sebe, A., Miskey, C., Hurst, L. D., Diarra, S., Kropp, M., Walter, P., Scherman, D., Ivics, Z., Izsvák, Z. & Johnen, S., 17 Mar 2017, In : Molecular Therapy - Nucleic Acids. 6, p. 302-314 13 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)
2013
56 Citations (Scopus)
2017

Depletion of somatic mutations in splicing-associated sequences in cancer genomes

Hurst, L. & Batada, N. N., 7 Nov 2017, In : Genome Biology. 18, 1, 12 p., 213.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
2018

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA

Yokoyama, M., Stevens, E., Laabei, M., Bacon, L., Heesom, K., Bayliss, S., Ooi, N., O'Neill, A. J., Murray, E., Williams, P., Lubben, A., Reeksting, S., Meric, G., Pascoe, B., Sheppard, S. K., Recker, M., Hurst, L. D. & Massey, R. C., 18 Jul 2018, In : Genome Biology. 19, 1, p. 1-12 12 p., 94.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)
2015
File
15 Citations (Scopus)
92 Downloads (Pure)
2014

Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients

Yin, S., Yang, J., Lin, B., Deng, W., Zhang, Y., Yi, X., Shi, Y., Tao, Y., Cai, J., Wu, C-I., Zhao, G., Hurst, L. D., Zhang, J., Hu, L. & Kong, X., 12 Aug 2014, In : Scientific Reports. 4, 6036.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
124 Downloads (Pure)
2013

Open questions: A logic (or lack thereof) of genome organization

Hurst, L. D., 28 May 2013, In : BMC Biology. 11, 58.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The form of a trade-off determines the response to competition

Maharjan, R., Nilsson, S., Sung, J., Haynes, K., Beardmore, R. E., Hurst, L. D., Ferenci, T. & Gudelj, I., Oct 2013, In : Ecology Letters. 16, 10, p. 1267-1276 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2012

Competition between transposable elements and mutator genes in bacteria

Feher, T., Bogos, B., Mehi, O., Fekete, G., Csorgo, B., Kovacs, K., Posfai, G., Papp, B., Hurst, L. D. & Pal, C., 1 Oct 2012, In : Molecular Biology and Evolution. 29, 10, p. 3153-3159

Research output: Contribution to journalArticle

21 Citations (Scopus)
2018
Open Access
6 Citations (Scopus)

Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias

Liu, H., Huang, J., Sun, X., Li, J., Hu, Y., Yu, L., Liti, G., Tian, D., Hurst, L. & Yang, S., 1 Jan 2018, In : Nature Ecology & Evolution. 2, 1, p. 164-173 10 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
43 Downloads (Pure)
2020

Codon Usage and Splicing Jointly Influence mRNA Localization

Hurst, L., 22 Apr 2020, In : Cell Systems. 10, 4, p. 351-362

Research output: Contribution to journalArticle

Open Access
2019

Evidence for the Success of a Quantitative Assessment Instrument for Teaching Evolution in Primary Schools in England

Buchan, L., Hejmadi, M. & Hurst, L., 2019, Evolution Education Re-considered. Harms, U. & Reiss, M. (eds.). UK: Springer, p. 21-40 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Duplication and retention biases of essential and non-essential genes revealed by systematic knockdown analyses

Woods, S., Coghlan, A., Rivers, D., Warnecke, T., Jeffries, S. J., Kwon, T., Rogers, A., Hurst, L. & Ahringer, J., 9 May 2013, In : Plos Genetics. 9, 5, e1003330.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2015

Genomic analysis of isolates from the United Kingdom 2012 pertussis outbreak reveals that vaccine antigen genes are unusually fast evolving

Sealey, K. L., Harris, S. R., Fry, N. K., Hurst, L. D., Gorringe, A. R., Parkhill, J. & Preston, A., 15 Jul 2015, In : Journal of Infectious Diseases. 212, 2, p. 294-301 8 p.

Research output: Contribution to journalArticle

Open Access
File
43 Citations (Scopus)
137 Downloads (Pure)
2017

Comparative analyses of selection operating on non-translated intergenic regions of diverse bacterial species

Thorpe, H. A., Bayliss, S. C., Hurst, L. D. & Feil, E. J., 5 May 2017, In : Genetics. 206, 1, p. 363-376 195784.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2018

Scientific aptitude better explains poor responses to teaching of evolution than psychological conflicts

Mead, R., Hejmadi, M. & Hurst, L. D., 1 Feb 2018, In : Nature Ecology & Evolution. 2, 2, p. 388-394 7 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
104 Downloads (Pure)
2019

Conditional expression explains molecular evolution of social genes in a microbe

de Oliveira, J. L., Morales, A. C., Stewart, B., Gruenheit, N., Engelmoer, J., Brown, S. B., de Brito, R. A., Hurst, L. D., Urrutia, A. O., Thompson, C. R. L. & Wolf, J. B., 23 Jul 2019, In : Nature Communications. 10, 1, p. 1-12 12 p., 3284.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2014

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

Wang, J., Xie, G., Singh, M., Tashakkori Ghanbarian, A., Raskó, T., Szvetnik, A., Cai, H., Besser, D., Prigione, A., Fuchs, N. V., Schumann, G. G., Chen, W., Lorincz, M. C., Ivics, Z., Hurst, L. D. & Izsvák, Z., 18 Dec 2014, In : Nature. 516, 7531, p. 405-409 5 p.

Research output: Contribution to journalArticle

Open Access
File
183 Citations (Scopus)
254 Downloads (Pure)
2017

Estimating the prevalence of functional exonic splice regulatory information

Savisaar, R. & Hurst, L. D., 1 Sep 2017, In : Human Molecular Genetics. 136, 9, p. 1059-1078 20 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)
2011
40 Citations (Scopus)
2015

Parent-progeny sequencing indicates higher mutation rates in heterozygotes

Yang, S., Wang, L., Huang, J., Zhang, X., Yuan, Y., Chen, J. Q., Hurst, L. D. & Tian, D., 23 Jul 2015, In : Nature. 523, 7561, p. 463-467 5 p.

Research output: Contribution to journalArticle

Open Access
File
68 Citations (Scopus)
206 Downloads (Pure)