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Author

  • Laurence Hurst
2011
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39 Citations (Scopus)
120 Downloads (Pure)
2016

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression

Wang, J., Singh, M., Sun, C., Besser, D., Prigione, A., Ivics, Z., Hurst, L. D. & Izsvák, Z., 1 Feb 2016, In : Nature Protocols. 11, 2, p. 327-346 20 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2014

Purifying selection on splice-related motifs, not expression level nor RNA folding, explains nearly all constraint on human lincRNAs

Schüler, A., Ghanbarian, A. T. & Hurst, L. D., 1 Dec 2014, In : Molecular Biology and Evolution. 31, 12, p. 3164-3183 20 p.

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)
2016

Why is the X chromosome so odd? Traffic analogy helped us crack the mystery

Hurst, L. D. & Huminiecki, L., 11 Jan 2016, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access
2018

Human evolution is still happening – possibly faster than ever

Hurst, L. D., 14 Nov 2018, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access
2016

Pluripotency and the endogenous retrovirus HERVH: conflict or serendipity?

Izsvák, Z., Wang, J., Singh, M., Mager, D. L. & Hurst, L. D., 1 Jan 2016, In : Bioessays. 38, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2015

The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome

the FANTOM consortium & Huminiecki, L., 31 Dec 2015, In : PLoS Biology. 13, 12, p. 1-48 48 p., e1002315.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)
46 Downloads (Pure)
2012

Direct and indirect consequences of meiotic recombination: Implications for genome evolution

Webster, M. T. & Hurst, L. D., Mar 2012, In : Trends in Genetics. 28, 3, p. 101-109 9 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)
2013
56 Citations (Scopus)
2011
4 Citations (Scopus)
2019

Evidence for the Success of a Quantitative Assessment Instrument for Teaching Evolution in Primary Schools in England

Buchan, L., Hejmadi, M. & Hurst, L., 2019, Evolution Education Re-considered. Harms, U. & Reiss, M. (eds.). UK: Springer, p. 21-40 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Duplication and retention biases of essential and non-essential genes revealed by systematic knockdown analyses

Woods, S., Coghlan, A., Rivers, D., Warnecke, T., Jeffries, S. J., Kwon, T., Rogers, A., Hurst, L. & Ahringer, J., 9 May 2013, In : Plos Genetics. 9, 5, e1003330.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Evidence for deep phylogenetic conservation of exonic splice-related constraints: Splice-related skews at exonic ends in the brown alga Ectocarpus are common and resemble those seen in humans

Wu, X., Tronholm, A., Fernandez Cáceres, E., Tovar-Corona, J. M., Chen, L., Urrutia, A. O. & Hurst, L. D., 2013, In : Genome biology and evolution. 5, 9, p. 1731-1745 15 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
130 Downloads (Pure)
2017

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker

Zadora, J., Singh, M., Herse, F., Przybyl, L., Haasse, N., Golic, M., Yung, H. W., Huppertz, B., Cartwright, J. E., Whitley, G., Johnsen, G. M., Levi, G., Isbruch, A., Schulz, H., Luft, F. C., Muller, D. N., Staff, A. C., Hurst, L., Dechend, R. & Izsvak, Z., 7 Nov 2017, In : Circulation. 136, 19, p. 1824-1839 16 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)
2013

Positively charged residues are the major determinants of ribosomal velocity

Charneski, C. A. & Hurst, L. D., 12 Mar 2013, In : PLoS Biology. 11, 3, e1001508.

Research output: Contribution to journalArticle

144 Citations (Scopus)
2017

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids

Thumann, G., Harmening, N., Prat-Souteyrand, C., Marie, C., Pastor, M., Sebe, A., Miskey, C., Hurst, L. D., Diarra, S., Kropp, M., Walter, P., Scherman, D., Ivics, Z., Izsvák, Z. & Johnen, S., 17 Mar 2017, In : Molecular Therapy - Nucleic Acids. 6, p. 302-314 13 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)
2014

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

Wang, J., Xie, G., Singh, M., Tashakkori Ghanbarian, A., Raskó, T., Szvetnik, A., Cai, H., Besser, D., Prigione, A., Fuchs, N. V., Schumann, G. G., Chen, W., Lorincz, M. C., Ivics, Z., Hurst, L. D. & Izsvák, Z., 18 Dec 2014, In : Nature. 516, 7531, p. 405-409 5 p.

Research output: Contribution to journalArticle

Open Access
File
185 Citations (Scopus)
259 Downloads (Pure)

A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators

Hurst, L. D., Sachenkova, O., Daub, C., Forrest, A. R. R. & Huminiecki, L., 31 Jul 2014, In : Genome Biology. 15, 7, 413.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)
2018
Open Access
File
11 Citations (Scopus)
37 Downloads (Pure)
2014

Environmentally responsive genome-wide accumulation of de novo Arabidopsis thaliana mutations and epimutations

Jiang, C., Mithani, A., Belfield, E. J., Mott, R., Hurst, L. D. & Harberd, N. P., 1 Nov 2014, In : Genome Research. 24, 11, p. 1821-1829 9 p.

Research output: Contribution to journalArticle

Open Access
81 Citations (Scopus)
2018

Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias

Liu, H., Huang, J., Sun, X., Li, J., Hu, Y., Yu, L., Liti, G., Tian, D., Hurst, L. & Yang, S., 1 Jan 2018, In : Nature Ecology & Evolution. 2, 1, p. 164-173 10 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
46 Downloads (Pure)

Scientific aptitude better explains poor responses to teaching of evolution than psychological conflicts

Mead, R., Hejmadi, M. & Hurst, L. D., 1 Feb 2018, In : Nature Ecology & Evolution. 2, 2, p. 388-394 7 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
109 Downloads (Pure)
2015

Genomic analysis of isolates from the United Kingdom 2012 pertussis outbreak reveals that vaccine antigen genes are unusually fast evolving

Sealey, K. L., Harris, S. R., Fry, N. K., Hurst, L. D., Gorringe, A. R., Parkhill, J. & Preston, A., 15 Jul 2015, In : Journal of Infectious Diseases. 212, 2, p. 294-301 8 p.

Research output: Contribution to journalArticle

Open Access
File
43 Citations (Scopus)
143 Downloads (Pure)
2017

Both maintenance and avoidance of RNA-binding protein interactions constrain coding region evolution

Savisaar, R. & Hurst, L., 1 May 2017, In : Molecular Biology and Evolution. 34, 5, p. 1110-1126

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
170 Downloads (Pure)
2014

Predicting the virulence of MRSA from its genome sequence

Laabei, M., Recker, M., Rudkin, J. K., Aldeljawi, M., Gulay, Z., Sloan, T. J., Williams, P., Endres, J. L., Bayles, K. W., Fey, P. D., Yajjala, V. K., Widhelm, T., Hawkins, E., Lewis, K., Parfett, S., Scowen, L., Peacock, S. J., Holden, M., Wilson, D., Read, T. D. & 6 others, Van Den Elsen, J., Priest, N. K., Feil, E. J., Hurst, L. D., Josefsson, E. & Massey, R. C., 1 May 2014, In : Genome Research. 24, 5, p. 839-849 11 p.

Research output: Contribution to journalArticle

Open Access
84 Citations (Scopus)
59 Downloads (Pure)
2016

Mutation rate analysis via parent- progeny sequencing of the perennial peach. II. No evidence for recombination associated mutation

Wang, L., Zhang, Y., Qin, C., Tian, D., Yang, S. & Hurst, L. D., 26 Oct 2016, In : Proceedings of the Royal Society B: Biological Sciences. 283, 1841, 20161785.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
198 Downloads (Pure)
2013

Open questions: A logic (or lack thereof) of genome organization

Hurst, L. D., 28 May 2013, In : BMC Biology. 11, 58.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2012

Competition between transposable elements and mutator genes in bacteria

Feher, T., Bogos, B., Mehi, O., Fekete, G., Csorgo, B., Kovacs, K., Posfai, G., Papp, B., Hurst, L. D. & Pal, C., 1 Oct 2012, In : Molecular Biology and Evolution. 29, 10, p. 3153-3159

Research output: Contribution to journalArticle

21 Citations (Scopus)
2011
40 Citations (Scopus)
2017

The best way to get children to understand evolution is to teach genetics first, finds study

Hurst, L., Hejmadi, M. & Mead, R., 23 May 2017, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access

Direct determination of the mutation rate in the bumblebee reveals evidence for weak recombination-associated mutation and an approximate rate constancy in insects

Liu, H., Jia, Y., Sun, X., Tian, D., Hurst, L. D. & Yang, S., 1 Jan 2017, In : Molecular Biology and Evolution. 34, 1, p. 119-130 12 p.

Research output: Contribution to journalArticle

Open Access
21 Citations (Scopus)
2011

Birt Hogg-Dube Syndrome-Associated FLCN Mutations Disrupt Protein Stability

Nahorski, M. S., Reiman, A., Lim, D. H. K., Nookala, R. K., Seabra, L., Lu, X. H., Fenton, J., Boora, U., Nordenskjold, M., Latif, F., Hurst, L. D. & Maher, E. R., Aug 2011, In : Human Mutation. 32, 8, p. 921-929 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Error prevention and mitigation as forces in the evolution of genes and genomes

Warnecke, T. & Hurst, L. D., Dec 2011, In : Nature Reviews Genetics. 12, 12, p. 875-881 7 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
142 Downloads (Pure)
2012

Young intragenic miRNAs are less coexpressed with host genes than old ones: Implications of miRNA-host gene coevolution

He, C., Li, Z., Chen, P., Huang, H., Hurst, L. D. & Chen, J., 2012, In : Nucleic Acids Research. 40, 9, p. 4002-4012 11 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2017

Male Mutation Bias Is the Main Force Shaping Chromosomal Substitution Rates in Monotreme Mammals

Link, V., Aguilar-Gómez, D., Ramírez-Suástegui, C., Hurst, L. D. & Cortez, D., 1 Sep 2017, In : Genome biology and evolution. 9, 9, p. 2198-2210 13 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2016

Purifying selection on exonic splice enhancers in intronless genes

Savisaar, R. & Hurst, L. D., Jun 2016, In : Molecular Biology and Evolution. 33, 6, p. 1396-1418

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
144 Downloads (Pure)
2015

Parent-progeny sequencing indicates higher mutation rates in heterozygotes

Yang, S., Wang, L., Huang, J., Zhang, X., Yuan, Y., Chen, J. Q., Hurst, L. D. & Tian, D., 23 Jul 2015, In : Nature. 523, 7561, p. 463-467 5 p.

Research output: Contribution to journalArticle

Open Access
File
70 Citations (Scopus)
216 Downloads (Pure)
2017

Teaching genetics prior to teaching evolution improves evolution understanding but not acceptance

Mead, R., Hejmadi, M. & Hurst, L. D., 31 May 2017, In : PLoS Biology. 15, 5, e2002255.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)
2018

Faster Evolving Primate Genes Are More Likely to Duplicate

O'Toole, Á. N., Hurst, L. D. & McLysaght, A., 1 Jan 2018, In : Molecular Biology and Evolution. 35, 1, p. 107-118 12 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)
2019

Conditional expression explains molecular evolution of social genes in a microbe

de Oliveira, J. L., Morales, A. C., Stewart, B., Gruenheit, N., Engelmoer, J., Brown, S. B., de Brito, R. A., Hurst, L. D., Urrutia, A. O., Thompson, C. R. L. & Wolf, J. B., 23 Jul 2019, In : Nature Communications. 10, 1, p. 1-12 12 p., 3284.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Exonic splice regulation imposes strong selection at synonymous sites

Savisaar, R. & Hurst, L., 1 Oct 2018, In : Genome Research. 28, 10, p. 1442-1454 13 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)
2017

Estimating the prevalence of functional exonic splice regulatory information

Savisaar, R. & Hurst, L. D., 1 Sep 2017, In : Human Molecular Genetics. 136, 9, p. 1059-1078 20 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)
2018

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA

Yokoyama, M., Stevens, E., Laabei, M., Bacon, L., Heesom, K., Bayliss, S., Ooi, N., O'Neill, A. J., Murray, E., Williams, P., Lubben, A., Reeksting, S., Meric, G., Pascoe, B., Sheppard, S. K., Recker, M., Hurst, L. D. & Massey, R. C., 18 Jul 2018, In : Genome Biology. 19, 1, p. 1-12 12 p., 94.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)
2017

Comparative analyses of selection operating on non-translated intergenic regions of diverse bacterial species

Thorpe, H. A., Bayliss, S. C., Hurst, L. D. & Feil, E. J., 5 May 2017, In : Genetics. 206, 1, p. 363-376 195784.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2011

Molecular genetics: The sound of silence

Hurst, L. D., 31 Mar 2011, In : Nature. 471, 7340, p. 582-583 2 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Atypical AT skew in firmicute genomes results from selection and not from mutation

Charneski, C. A., Honti, F., Bryant, J. M., Hurst, L. D. & Feil, E. J., 15 Sep 2011, In : Plos Genetics. 7, 9, 14 p., e1002283.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2016

Why did sex evolve? Researchers edge closer to solving longstanding mystery

Hurst, L., 29 Feb 2016, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access
2019

ENDOGENOUS RETROVIRUS TRANSCRIPTION AS A MARKER FOR PRIMATE NAÏVE PLURIPOTENT STEM CELLS

Wang, J., Izsvák, Z. & Hurst, L., 2019, Patent No. WO 2016/055519 A1(EP3204490, US2017313978), 7 Oct 2015, Priority date 7 Oct 2014, Priority No. 10 2014 114 558.5

Research output: Patent

2011

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

Garfield, A. S., Cowley, M., Smith, F. M., Moorwood, K., Stewart-Cox, J. E., Gilroy, K., Baker, S., Xia, J., Dalley, J. W., Hurst, L. D., Wilkinson, L. S., Isles, A. R. & Ward, A., 27 Jan 2011, In : Nature. 469, 7331, p. 534-538 5 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)
2012

Late-replicating domains have higher divergence and diversity in Drosophila melanogaster

Weber, C. C., Pink, C. J. & Hurst, L. D., Feb 2012, In : Molecular Biology and Evolution. 29, 2, p. 873-882 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)