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  • Barry Potter
2012

Fibrinogen—a possible extracellular target for inositol phosphates

Grint, T., Riley, A. M., Mills, S. J., Potter, B. V. L. & Safrany, S. T., 1 Dec 2012, In : Messenger. 1, 2, p. 160-166

Research output: Contribution to journalArticle

2020

THERAPEUTICS USE OF PYRIDINIUM COMPOUNDS TO MODULATE NAADP ACTIVITY

Dowden, J., Galione, A. & Potter, B., 2020, IPC No. A61K31/4425; A61K31/4439; A61K45/06; C07D213/20; C07D213/80; C07D495/04;, Patent No. WO2005054198A3, 6 Dec 2004, Priority date 5 Dec 2003, Priority No. 0328134.0

Research output: Patent

2015

Design, Synthesis, and Chemical and Biological Properties of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose

Tsuzuki, T., Takano, S., Sakaguchi, N., Kudoh, T., Murayama, T., Sakurai, T., Higashida, H., Weber, K., Guse, A. H., Kameda, T., Hirokawa, T., Kumaki, Y., Arisawa, M., Potter, B. & Shuto, S., Jun 2015, In : Messenger. 3, 1-2, p. 35-51 17 p.

Research output: Contribution to journalArticle

Open Access
File
128 Downloads (Pure)
2012

Aberrant cyclization affords a C-6 modified cyclic adenosine 5′-diphosphoribose analogue with biological activity in Jurkat T cells

Moreau, C., Kirchberger, T., Zhang, B., Thomas, M. P., Weber, K., Guse, A. H. & Potter, B. V. L., 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1478-1489

Research output: Contribution to journalArticle

14 Citations (Scopus)
2013

Regioselective opening of myo-inositol orthoesters: Mechanism and synthetic utility

Godage, H. Y., Riley, A. M., Woodman, T. J., Thomas, M. P., Mahon, M. F. & Potter, B. V. L., 15 Mar 2013, In : Journal of Organic Chemistry. 78, 6, p. 2275-2288

Research output: Contribution to journalArticle

9 Citations (Scopus)
2011

Structure-activity relationships of C-17-substituted estratriene-3-O-sulfamates as anticancer agents

Jourdan, F., Leese, M. P., Dohle, W., Ferrandis, E., Newman, S. P., Chander, S., Purohit, A. & Potter, B. V. L., 14 Jul 2011, In : Journal of Medicinal Chemistry. 54, 13, p. 4863-4879

Research output: Contribution to journalArticle

15 Citations (Scopus)
2013

The structural biology of oestrogen metabolism

Thomas, M. P. & Potter, B. V. L., 2013, In : Journal of Steroid Biochemistry and Molecular Biology. 137, p. 27-49

Research output: Contribution to journalArticle

55 Citations (Scopus)
2020

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5'-diphosphate ribose (ADPR)

Potter, B., Watt, J. M. & Baszczynski, O., 2020, In : RSC Advances. 10, 3, p. 1776-1785

Research output: Contribution to journalArticle

Open Access
2013

Structure–ativity relationship of adenosine 5′-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists

Moreau, C., Kirchberger, T., Swarbrick, J. M., Bartlett, S. J., Fliegert, R., Yorgan, T., Bauche, A., Harneit, A., Guse, A. H. & Potter, B. V. L., 27 Dec 2013, In : Journal of Medicinal Chemistry. 56, 24, p. 10079-10102

Research output: Contribution to journalArticle

32 Citations (Scopus)
2019

Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2

Potter, B., Watt, J. M. & Baszczynski, O., 17 May 2019, In : Journal of Organic Chemistry. 84, 10, p. 6143-6157 15 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
10 Downloads (Pure)
2011

Discovery of adamantyl heterocyclic ketones as potent 11 beta-hydroxysteroid dehydrogenase type 1 inhibitors

Su, X., Vicker, N., Thomas, M. P., Pradaux-Caggiano, F., Halem, H., Culler, M. D. & Potter, B. V. L., 1 Aug 2011, In : ChemMedChem. 6, 8, p. 1439-1451

Research output: Contribution to journalArticle

8 Citations (Scopus)
2015

The in vitro and in vivo activity of the microtubule disruptor STX140 is mediated by Hif-1 alpha and CAIX expression

Stengel, C., Newman, S. P., Leese, M. P., Thomas, M. P., Potter, B. V. L., Reed, M. J., Purohit, A. & Foster, P. A., 1 Oct 2015, In : Anticancer Research. 35, 10, p. 5249-5262 14 p.

Research output: Contribution to journalArticle

2011

The steroid sulfatase inhibitor BN-83495 inhibits the growth of DMBA induced mammary tumors in rats alone or in combination with estradiol receptor blockers

Koob, Z., Perez, A., Bascompta, E., Soulard, C., Caroline, C., Hillairet de Boisferon, M., Woo, L. W. L., Potter, B. V. L., Reed, M. J., Ali, T., Bichat, F. & Prevost, G., 2011, (Acceptance date) In : Breast Cancer Research and Treatment.

Research output: Contribution to journalArticle

Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor irosustat (STX64, BN83495)

Woo, L. W. L., Ganeshapillai, D., Thomas, M. P., Sutcliffe, O. B., Malini, B., Mahon, M. F., Purohit, A. & Potter, B. V. L., 4 Nov 2011, In : ChemMedChem. 6, 11, p. 2019-2034 16 p.

Research output: Contribution to journalArticle

Open Access
47 Citations (Scopus)
2014

The enzymes of human diphosphoinositol polyphosphate metabolism

Thomas, M. P. & Potter, B. V. L., Jan 2014, In : FEBS Journal. 281, 1, p. 14-33 20 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2017

SHIP2: structure, function and inhibition

Thomas, M. P., Erneux, C. & Potter, B. V. L., 1 Feb 2017, In : ChemBiochem. 18, 3, p. 233-247

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
255 Downloads (Pure)
2013

Stimulation of Inositol 1,4,5-Trisphosphate (IP3) Receptor Subtypes by Analogues of IP3

Saleem, H., Tovey, S. C., Rahman, T., Riley, A. M., Potter, B. V. L. & Taylor, C. W., 30 Jan 2013, In : PLoS ONE. 8, 1, 54877.

Research output: Contribution to journalArticle

15 Citations (Scopus)

STX2171, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, is efficacious in vivo in a novel hormone-dependent prostate cancer model

Day, J. M., Foster, P. A., Tutill, H. J., Schmidlin, F., Sharland, C. M., Hargrave, J. D., Vicker, N., Potter, B. V. L., Reed, M. J. & Purohit, A., Feb 2013, In : Endocrine-Related Cancer. 20, 1, p. 53-64 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2011

The effects of paclitaxel and STX140 on early-and late-stage breast cancer in tte clinically relevant C3(1)/SV40 mouse model

Newman, S. P., Day, J. M., Potter, B. V. L., Reed, M. J. & Purohit, A., 2011, (Acceptance date) In : European Journal of Cancer.

Research output: Contribution to journalArticle

2015

In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer

Stengel, C., Newman, S. P., Day, J. M., Chander, S. K., Jourdan, F. L., Leese, M. P., Ferrandis, E., Regis-lydi, S., Potter, B. V. L., Reed, M. J., Purohit, A. & Foster, P. A., 15 Jul 2015, In : British Journal of Cancer. 111, 2, p. 300-308

Research output: Contribution to journalArticle

10 Citations (Scopus)
2012

Adamantyl carboxamides and acetamides as potent human 11β- hydroxysteroid dehydrogenase type 1 inhibitors

Su, X., Halem, H. A., Thomas, M. P., Moutrille, C., Culler, M. D., Vicker, N. & Potter, B. V. L., 1 Nov 2012, In : Bioorganic and Medicinal Chemistry. 20, 21, p. 6394-6402

Research output: Contribution to journalArticle

6 Citations (Scopus)
2017
Open Access
3 Citations (Scopus)

Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5'-diphosphate ribose”

Watt, J. M., Graeff, R., Thomas, M. P. & Potter, B., 23 Nov 2017, In : Scientific Reports. 7, 16100.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
35 Downloads (Pure)
2012

A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery

Mills, S. J., Persson, C., Cozier, G., Thomas, M. P., Trésaugues, L., Erneux, C., Riley, A. M., Nordlund, P. & Potter, B. V. L., 18 May 2012, In : ACS Chemical Biology. 7, 5, p. 822-828

Research output: Contribution to journalArticle

24 Citations (Scopus)
2018

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers

Watt, J. M., Thomas, M. & Potter, B., 15 Oct 2018, In : Scientific Reports. 8, 15268.

Research output: Contribution to journalArticle

Open Access
2016

Crystal structures of type-II inositol polyphosphate 5-phosphatase INPP5B with synthetic inositol polyphosphate surrogates reveal new mechanistic insights for the inositol 5-phosphatase family

Mills, S. J., Silvander, C., Cozier, G., Trésaugues, L., Nordlund, P. & Potter, B. V. L., 8 Mar 2016, In : Biochemistry. 55, 9, p. 1384-1397

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
128 Downloads (Pure)
2014

16- AND 17- DEUTERATED ESTROGEN-3-SULFAMATES AS ESTROGENIC AGENTS

Potter, B., 14 Aug 2014, IPC No. A61K31/565; A61P5/30; C07J41/00;, Patent No. WO2014122480A1, 10 Feb 2014, Priority date 11 Feb 2013, Priority No. 1302368.4

Research output: Patent

2011

Novel Inositol Phosphate Derivatives

Falasca, M., Riley, A., Godage, H. & Potter, B., 3 Jun 2011, IPC No. A61K31/661, Patent No. WO2011064559 (A2)

Research output: Patent

2014

Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery

Wang, H., Godage, H. Y., Riley, A. M., Weaver, J. D., Shears, S. B. & Potter, B. V. L., 22 May 2014, In : Chemistry & Biology. 21, 5, p. 689-699 11 p.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)
2015

Calcium Signalling Triggered by NAADP in T Cells Determines Cell Shape and Motility During Immune Synapse Formation

Nebel, M., Zhang, B., Odoardi, F., Flugel, A., Potter, B. & Guse, A. H., 2015, In : Messenger. 4, 1, p. 104-111

Research output: Contribution to journalArticle

Open Access
File
119 Downloads (Pure)

Estrogen O-sulfamates and their analogues: clinical steroid sulfatase inhibitors with broad potential

Thomas, M. P. & Potter, B. V. L., 1 Sep 2015, In : Journal of Steroid Biochemistry and Molecular Biology. 153, p. 160-169 10 p., 4391.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2016

Insights into the activation mechanism of class I HDAC complexes by inositol phosphates

Watson, P. J., Millard, C. J., Riley, A. M., Robertson, N. S., Wright, L. C., Godage, H. Y., Cowley, S. M., Jamieson, A. G., Potter, B. V. L. & Schwabe, J. W. R., 25 Apr 2016, In : Nature Communications. 7, 11262.

Research output: Contribution to journalArticle

Open Access
File
71 Citations (Scopus)
114 Downloads (Pure)
2011

Steroid sulfatase: a pivotal player in estrogen synthesis and metabolism

Purohit, A., Woo, L. W. L. & Potter, B. V. L., 4 Jul 2011, In : Molecular and Cellular Endocrinology. 340, 2, p. 154-160

Research output: Contribution to journalArticle

Open Access
File
49 Citations (Scopus)
161 Downloads (Pure)
2018

Steroid sulphatase inhibition via aryl sulphamates: Clinical progress, mechanism and future prospects

Potter, B. V. L., 1 Aug 2018, In : Journal of Molecular Endocrinology. 61, 2, p. T233-T252 20 p.

Research output: Contribution to journalReview article

Open Access
19 Citations (Scopus)
2015

Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Womens Health

Thomas, M. P. & Potter, B. V. L., 8 Oct 2015, In : Journal of Medicinal Chemistry. 58, 19, p. 7634-7658 25 p.

Research output: Contribution to journalReview article

36 Citations (Scopus)
2018

Quinazolinone-based Anticancer Agents: Synthesis, Anti-proliferative SAR, Anti-tubulin Activity and Tubulin Co-crystal Structure

Dohle, W., Jourdan, F., Menchon, G., Prota, A., Foster, P. A., Mannion, P., Hamel, E., Thomas, M., Kasprzyk, P. G., Ferrandis, E., Steinmetz, M. O., Leese, M. & Potter, B., 2018, (Unpublished) In : Journal of Medicinal Chemistry. 49 p.

Research output: Contribution to journalArticle

A Fluorescent Probe Identifies Active Site Ligands of Inositol Pentakisphosphate 2-Kinase

Potter, B. & Godage, H., 11 Oct 2018, In : Journal of Medicinal Chemistry. 61, 19, p. 8838-8846 9 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
30 Downloads (Pure)
2011

Synthesis of cyclic adenosine 5 '-diphosphate ribose analogues: a C2 ' endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor

Moreau, C., Ashamu, G. A., Bailey, V. C., Galione, A., Guse, A. H. & Potter, B. V. L., 2011, In : Organic and Biomolecular Chemistry. 9, 1, p. 278-290

Research output: Contribution to journalArticle

17 Citations (Scopus)
2017

2ʹ-Deoxyadenosine 5ʹ-diphosphoribose is an endogenous TRPM2 superagonist

Fliegert, R., Bauche, A., Wolf Pérez, A-M., Watt, J. M., Rozewitz, M. D., Winzer, R., Janus, M., Gu, F., Rosche, A., Harneit, A., Flato, M., Moreau, C., Kirchberger, T., Wolters, V., Potter, B. V. L. & Guse, A. H., 1 Sep 2017, In : Nature Chemical Biology. 13, p. 1036-1044 9 p.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
152 Downloads (Pure)
2012

Total synthesis of a cyclic adenosine 5′-diphosphate ribose receptor agonist

Swarbrick, J. M. & Potter, B. V. L., 2012, In : Journal of Organic Chemistry. 77, 9, p. 4191-4197

Research output: Contribution to journalArticle

17 Citations (Scopus)

Antagonism of NAADP mediated calcium signaling ameliorates arrythmias in the heart

Nebel, M., Schworer, A., Siebrands, C. C., Limbrock, A-C., Swarbrick, J. M., Hohenegger, M., Geisler, A., Herich, L., Schlegel, S., Carrier, L., Eschenhagen, T., Potter, B. V. L., Ehmke, H. & Guse, A. H., 2012, (Acceptance date) In : Circulation.

Research output: Contribution to journalArticle

Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors

Woo, L. W. L., Leblond, B., Purohit, A. & Potter, B. V. L., 15 Apr 2012, In : Bioorganic and Medicinal Chemistry. 20, 8, p. 2506-2519

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
151 Downloads (Pure)
2015

Synthetic tools for studying the chemical biology of InsP8

Riley, A. M., Wang, H., Shears, S. B. & Potter, B. V. L., 14 Aug 2015, In : Chemical Communications. 51, 63, p. 12605-12608 4 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
107 Downloads (Pure)
2012

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase

Riley, A. M., Wang, H., Weaver, J. D., Shears, S. B. & Potter, B. V. L., 24 Oct 2012, In : Chemical Communications. 48, 92, p. 11292-11294 3 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2018

Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease

Zhang, B., Watt, J. M., Cordiglieri, C., Dammermann, W., Mahon, M., Flugel, A., Guse, A. H. & Potter, B., 13 Nov 2018, In : Scientific Reports. 8, 17 p., 16775.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2013

Synthesis and structure-activity relationship studies of derivatives of the dual aromatase-sulfatase inhibitor 4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

Woo, L. W. L., Wood, P. M., Bubert, C., Thomas, M. P., Purohit, A. & Potter, B. V. L., May 2013, In : ChemMedChem. 8, 5, p. 779-799 21 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2015

Designer small molecules to target calcium signalling

Swarbrick, J. M., Riley, A. M., Mills, S. J. & Potter, B. V. L., 1 Jun 2015, In : Biochemical Society Transactions. 43, 3, p. 417-425 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

Simple synthesis of 32P-labelled inositol hexakisphosphates for study of phosphate transformations

Whitfield, H., Riley, A. M., Diogenous, S., Godage, H. Y., Potter, B. & Brearley, C. A., 27 Jun 2017, In : Plant and Soil.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2012

Steroidomimetic tetrahydroisoquinolines for the design of new microtubule disruptors

Leese, M. P., Jourdan, F., Dohle, W., Kimberley, M. R., Thomas, M. P., Bai, R., Hamel, E., Ferrandis, E. & Potter, B. V. L., 2012, In : ACS Medicinal Chemistry Letters. 3, 1, p. 5-9

Research output: Contribution to journalArticle

27 Citations (Scopus)
2011

Crystal structures of II beta-hydroxysteroid dehydrogenase type I and their use in drug discovery

Thomas, M. P. & Potter, B. V. L., Mar 2011, In : Future Medicinal Chemistry. 3, 3, p. 367-390

Research output: Contribution to journalArticle

22 Citations (Scopus)