Find Research Outputs

Search concepts
Selected filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011

Author

  • Barry Potter
2011

Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11 beta-hydroxysteroid dehydrogenase type 1

Su, X., Pradaux-Caggiano, F., Vicker, N., Thomas, M. P., Halem, H., Culler, M. D. & Potter, B. V. L., 5 Sep 2011, In : ChemMedChem. 6, 9, p. 1616-1629

Research output: Contribution to journalArticle

10 Citations (Scopus)

Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates

Wood, P. M., Woo, L. W. L., Thomas, M. P., Mahon, M. F., Purohit, A. & Potter, B. V. L., 1 Aug 2011, In : ChemMedChem. 6, 8, p. 1423-1438

Research output: Contribution to journalArticle

41 Citations (Scopus)

Crystal structures of II beta-hydroxysteroid dehydrogenase type I and their use in drug discovery

Thomas, M. P. & Potter, B. V. L., Mar 2011, In : Future Medicinal Chemistry. 3, 3, p. 367-390

Research output: Contribution to journalArticle

22 Citations (Scopus)

Development of steroid sulfatase inhibitors

Woo, L. W. L., Purohit, A. & Potter, B. V. L., 4 Jul 2011, In : Molecular and Cellular Endocrinology. 340, 2, p. 175-185

Research output: Contribution to journalArticle

Open Access
File
41 Citations (Scopus)
148 Downloads (Pure)

Discovery of adamantyl heterocyclic ketones as potent 11 beta-hydroxysteroid dehydrogenase type 1 inhibitors

Su, X., Vicker, N., Thomas, M. P., Pradaux-Caggiano, F., Halem, H., Culler, M. D. & Potter, B. V. L., 1 Aug 2011, In : ChemMedChem. 6, 8, p. 1439-1451

Research output: Contribution to journalArticle

8 Citations (Scopus)

Hybrid dual aromatase-steroid sulfatase inhibitors with exquisite picomolar inhibitory activity

Woo, L. W. L., Bubert, C., Purohit, A. & Potter, B. V. L., Mar 2011, In : ACS Medicinal Chemistry Letters. 2, 3, p. 243-247

Research output: Contribution to journalArticle

27 Citations (Scopus)

Novel Inositol Phosphate Derivatives

Falasca, M., Riley, A., Godage, H. & Potter, B., 3 Jun 2011, IPC No. A61K31/661, Patent No. WO2011064559 (A2)

Research output: Patent

Steroid sulfatase: a pivotal player in estrogen synthesis and metabolism

Purohit, A., Woo, L. W. L. & Potter, B. V. L., 4 Jul 2011, In : Molecular and Cellular Endocrinology. 340, 2, p. 154-160

Research output: Contribution to journalArticle

Open Access
File
49 Citations (Scopus)
151 Downloads (Pure)

Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor irosustat (STX64, BN83495)

Woo, L. W. L., Ganeshapillai, D., Thomas, M. P., Sutcliffe, O. B., Malini, B., Mahon, M. F., Purohit, A. & Potter, B. V. L., 4 Nov 2011, In : ChemMedChem. 6, 11, p. 2019-2034 16 p.

Research output: Contribution to journalArticle

Open Access
47 Citations (Scopus)

Structure-activity relationships of C-17-substituted estratriene-3-O-sulfamates as anticancer agents

Jourdan, F., Leese, M. P., Dohle, W., Ferrandis, E., Newman, S. P., Chander, S., Purohit, A. & Potter, B. V. L., 14 Jul 2011, In : Journal of Medicinal Chemistry. 54, 13, p. 4863-4879

Research output: Contribution to journalArticle

15 Citations (Scopus)

Synthesis of cyclic adenosine 5 '-diphosphate ribose analogues: a C2 ' endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor

Moreau, C., Ashamu, G. A., Bailey, V. C., Galione, A., Guse, A. H. & Potter, B. V. L., 2011, In : Organic and Biomolecular Chemistry. 9, 1, p. 278-290

Research output: Contribution to journalArticle

17 Citations (Scopus)

The effects of paclitaxel and STX140 on early-and late-stage breast cancer in tte clinically relevant C3(1)/SV40 mouse model

Newman, S. P., Day, J. M., Potter, B. V. L., Reed, M. J. & Purohit, A., 2011, (Accepted/In press) In : European Journal of Cancer.

Research output: Contribution to journalArticle

The steroid sulfatase inhibitor BN-83495 inhibits the growth of DMBA induced mammary tumors in rats alone or in combination with estradiol receptor blockers

Koob, Z., Perez, A., Bascompta, E., Soulard, C., Caroline, C., Hillairet de Boisferon, M., Woo, L. W. L., Potter, B. V. L., Reed, M. J., Ali, T., Bichat, F. & Prevost, G., 2011, (Accepted/In press) In : Breast Cancer Research and Treatment.

Research output: Contribution to journalArticle

2012

Aberrant cyclization affords a C-6 modified cyclic adenosine 5′-diphosphoribose analogue with biological activity in Jurkat T cells

Moreau, C., Kirchberger, T., Zhang, B., Thomas, M. P., Weber, K., Guse, A. H. & Potter, B. V. L., 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1478-1489

Research output: Contribution to journalArticle

14 Citations (Scopus)

Adamantyl carboxamides and acetamides as potent human 11β- hydroxysteroid dehydrogenase type 1 inhibitors

Su, X., Halem, H. A., Thomas, M. P., Moutrille, C., Culler, M. D., Vicker, N. & Potter, B. V. L., 1 Nov 2012, In : Bioorganic and Medicinal Chemistry. 20, 21, p. 6394-6402

Research output: Contribution to journalArticle

6 Citations (Scopus)

Antagonism of NAADP mediated calcium signaling ameliorates arrythmias in the heart

Nebel, M., Schworer, A., Siebrands, C. C., Limbrock, A-C., Swarbrick, J. M., Hohenegger, M., Geisler, A., Herich, L., Schlegel, S., Carrier, L., Eschenhagen, T., Potter, B. V. L., Ehmke, H. & Guse, A. H., 2012, (Accepted/In press) In : Circulation.

Research output: Contribution to journalArticle

A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery

Mills, S. J., Persson, C., Cozier, G., Thomas, M. P., Trésaugues, L., Erneux, C., Riley, A. M., Nordlund, P. & Potter, B. V. L., 18 May 2012, In : ACS Chemical Biology. 7, 5, p. 822-828

Research output: Contribution to journalArticle

23 Citations (Scopus)

Contribution of phosphates and adenine to the potency of adenophostins at the IP 3 receptor: synthesis of all possible bisphosphates of adenophostin A

Sureshan, K. M., Riley, A. M., Thomas, M. P., Tovey, S. C., Taylor, C. W. & Potter, B. V. L., 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1706-1720

Research output: Contribution to journalArticle

15 Citations (Scopus)

Determination of neo-and D-chiro-inositol hexakisphosphate in soils by solution 31P NMR spectroscopy

Turner, B. L., Cheesman, A. W., Godage, H. Y., Riley, A. M. & Potter, B. V. L., 2012, In : Environmental Science & Technology. 46, 9, p. 4994-5002

Research output: Contribution to journalArticle

90 Citations (Scopus)

Fibrinogen—a possible extracellular target for inositol phosphates

Grint, T., Riley, A. M., Mills, S. J., Potter, B. V. L. & Safrany, S. T., 1 Dec 2012, In : Messenger. 1, 2, p. 160-166

Research output: Contribution to journalArticle

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase

Riley, A. M., Wang, H., Weaver, J. D., Shears, S. B. & Potter, B. V. L., 24 Oct 2012, In : Chemical Communications. 48, 92, p. 11292-11294 3 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Steroidomimetic tetrahydroisoquinolines for the design of new microtubule disruptors

Leese, M. P., Jourdan, F., Dohle, W., Kimberley, M. R., Thomas, M. P., Bai, R., Hamel, E., Ferrandis, E. & Potter, B. V. L., 2012, In : ACS Medicinal Chemistry Letters. 3, 1, p. 5-9

Research output: Contribution to journalArticle

27 Citations (Scopus)

Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors

Woo, L. W. L., Leblond, B., Purohit, A. & Potter, B. V. L., 15 Apr 2012, In : Bioorganic and Medicinal Chemistry. 20, 8, p. 2506-2519

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
149 Downloads (Pure)

Synthesis and evaluation of thiadiazole derivatives as inhibitors of 11β-hydroxysteroid dehydrogenase type 1

Pradaux-Caggiano, F., Su, X., Vicker, N., Thomas, M. P., Smithen, D., Halem, H. A., Culler, M. D. & Potter, B. V. L., 1 Sep 2012, In : MedChemComm. 3, 9, p. 1117-1124

Research output: Contribution to journalArticle

6 Citations (Scopus)

Total synthesis of a cyclic adenosine 5′-diphosphate ribose receptor agonist

Swarbrick, J. M. & Potter, B. V. L., 2012, In : Journal of Organic Chemistry. 77, 9, p. 4191-4197

Research output: Contribution to journalArticle

17 Citations (Scopus)
2013

CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5′-Diphosphate Ribose Template

Moreau, C., Liu, Q., Graeff, R., Wagner, G. K., Thomas, M. P., Swarbrick, J. M., Shuto, S., Lee, H. C., Hao, Q. & Potter, B. V. L., 19 Jun 2013, In : PLoS ONE. 8, 6, 15 p., e66247.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
129 Downloads (Pure)

Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger

Tsuzuki, T., Sakaguchi, N., Kudoh, T., Takano, S., Uehara, M., Murayama, T., Sakurai, T., Hashii, M., Higashida, H., Weber, K., Guse, A. H., Kameda, T., Hirokawa, T., Kumaki, Y., Potter, B. V. L., Fukuda, H., Arisawa, M. & Shuto, S., 24 Jun 2013, In : Angewandte Chemie-International Edition. 52, 26, p. 6633-6637

Research output: Contribution to journalArticle

13 Citations (Scopus)

Inframolecular acid-base and coordination properties towards Na+ and Mg2+ of myo-inositol 1,3,4,5,6-pentakisphosphate: A structural approach to biologically relevant species

Veiga, N., Torres, J., Macho, I., Gómez, K., Godage, H. Y., Riley, A. M., Potter, B. V. L., González, G. & Kremer, C., 7 May 2013, In : Dalton Transactions. 42, 17, p. 6021-6032

Research output: Contribution to journalArticle

6 Citations (Scopus)

Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation

Nebel, M., Schwoerer, A. P., Warszta, D., Siebrands, C. C., Limbrock, A-C., Swarbrick, J. M., Fliegert, R., Weber, K., Bruhn, S., Hohenegger, M., Geisler, A., Herich, L., Schlegel, S., Carrier, L., Eschenhagen, T., Potter, B. V. L., Ehmke, H. & Guse, A. H., 31 May 2013, In : Journal of Biological Chemistry. 288, 22, p. 16017-16030

Research output: Contribution to journalArticle

21 Citations (Scopus)

Regioselective opening of myo-inositol orthoesters: Mechanism and synthetic utility

Godage, H. Y., Riley, A. M., Woodman, T. J., Thomas, M. P., Mahon, M. F. & Potter, B. V. L., 15 Mar 2013, In : Journal of Organic Chemistry. 78, 6, p. 2275-2288

Research output: Contribution to journalArticle

9 Citations (Scopus)

Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by Adenophostin A and its analogues

Saleem, H., Tovey, S. C., Riley, A. M., Potter, B. V. L. & Taylor, C. W., 28 Feb 2013, In : PLoS ONE. 8, 2, e58027.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
83 Downloads (Pure)

Stimulation of Inositol 1,4,5-Trisphosphate (IP3) Receptor Subtypes by Analogues of IP3

Saleem, H., Tovey, S. C., Rahman, T., Riley, A. M., Potter, B. V. L. & Taylor, C. W., 30 Jan 2013, In : PLoS ONE. 8, 1, 54877.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Structure–ativity relationship of adenosine 5′-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists

Moreau, C., Kirchberger, T., Swarbrick, J. M., Bartlett, S. J., Fliegert, R., Yorgan, T., Bauche, A., Harneit, A., Guse, A. H. & Potter, B. V. L., 27 Dec 2013, In : Journal of Medicinal Chemistry. 56, 24, p. 10079-10102

Research output: Contribution to journalArticle

31 Citations (Scopus)

STX2171, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, is efficacious in vivo in a novel hormone-dependent prostate cancer model

Day, J. M., Foster, P. A., Tutill, H. J., Schmidlin, F., Sharland, C. M., Hargrave, J. D., Vicker, N., Potter, B. V. L., Reed, M. J. & Purohit, A., Feb 2013, In : Endocrine-Related Cancer. 20, 1, p. 53-64 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Subtype-selective regulation of IP3 receptors by thimerosal via cysteine residues within the IP3-binding core and suppressor domain

Khan, S. A., Rossi, A. M., Riley, A. M., Potter, B. V. L. & Taylor, C. W., 15 Apr 2013, In : Biochemical Journal. 451, 2, p. 177-184

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
107 Downloads (Pure)

Synthesis and structure-activity relationship studies of derivatives of the dual aromatase-sulfatase inhibitor 4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

Woo, L. W. L., Wood, P. M., Bubert, C., Thomas, M. P., Purohit, A. & Potter, B. V. L., May 2013, In : ChemMedChem. 8, 5, p. 779-799 21 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The structural biology of oestrogen metabolism

Thomas, M. P. & Potter, B. V. L., 2013, In : Journal of Steroid Biochemistry and Molecular Biology. 137, p. 27-49

Research output: Contribution to journalArticle

55 Citations (Scopus)
2014

16- AND 17- DEUTERATED ESTROGEN-3-SULFAMATES AS ESTROGENIC AGENTS

Potter, B., 14 Aug 2014, IPC No. A61K31/565; A61P5/30; C07J41/00;, Patent No. WO2014122480A1, 10 Feb 2014, Priority date 11 Feb 2013, Priority No. 1302368.4

Research output: Patent

Cellular internalisation of an inositol phosphate visualised by using fluorescent InsP5

Riley, A. M., Windhorst, S., Lin, H-Y. & Potter, B. V. L., 3 Jan 2014, In : ChemBiochem. 15, 1, p. 57-67 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

'Click cyclic ADP-ribose': A neutral second messenger mimic

Swarbrick, J. M., Graeff, R., Garnham, C., Thomas, M. P., Galione, A. & Potter, B. V. L., 7 Mar 2014, In : Chemical Communications. 50, 19, p. 2458-2461 4 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
99 Downloads (Pure)

Cyclic adenosine 5′-diphosphate ribose analogs without a southern ribose inhibit ADP-ribosyl cyclase-hydrolase CD38

Swarbrick, J. M., Graeff, R., Zhang, H., Thomas, M. P., Hao, Q. & Potter, B. V. L., 23 Oct 2014, In : Journal of Medicinal Chemistry. 57, 20, p. 8517-8529 13 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
87 Downloads (Pure)

Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response

Pulloor, N. K., Nair, S., Kostic, A. D., Bist, P., Weaver, J. D., Riley, A. M., Tyagi, R., Uchil, P. D., York, J. D., Snyder, S. H., García-Sastre, A., Potter, B. V. L., Lin, R., Shears, S. B., Xavier, R. J. & Krishnan, M. N., 27 Feb 2014, In : PLoS Pathogens. 10, 2, e1003981.

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)

Optimisation of tetrahydroisoquinoline-based chimeric microtubule disruptors

Dohle, W., Leese, M. P., Jourdan, F. L., Chapman, C. J., Hamel, E., Ferrandis, E. & Potter, B. V. L., Aug 2014, In : ChemMedChem. 9, 8, p. 1783-1793 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Synthesis, Antitubulin, and Antiproliferative SAR of C3/C1-Substituted Tetrahydroisoquinolines

Dohle, W., Leese, M. P., Jourdan, F. L., Major, M. R., Bai, R., Hamel, E., Ferrandis, E., Kasprzyk, P. G., Fiore, A., Newman, S. P., Purohit, A. & Potter, B. V. L., Feb 2014, In : ChemMedChem. 9, 2, p. 350-370

Research output: Contribution to journalArticle

12 Citations (Scopus)

Synthesis, anti-tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones

Leese, M. P., Jourdan, F. L., Major, M. R., Dohle, W., Thomas, M. P., Hamel, E., Ferrandis, E., Mahon, M. F., Newman, S. P., Purohit, A. & Potter, B. V. L., Apr 2014, In : ChemMedChem. 9, 4, p. 798-812

Research output: Contribution to journalArticle

11 Citations (Scopus)

Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery

Wang, H., Godage, H. Y., Riley, A. M., Weaver, J. D., Shears, S. B. & Potter, B. V. L., 22 May 2014, In : Chemistry & Biology. 21, 5, p. 689-699 11 p.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)

Synthetic inositol phosphate analogues in complex with PPIP5K2 uncover a substrate capture site as a target for drug discovery

Wang, H., Godage, H., Riley, A., Weaver, J. D., Potter, B. & Shears, S. B., 2014, In : Chemistry & Biology.

Research output: Contribution to journalArticle

Tetrahydroisoquinolinone-based steroidomimetic and chimeric microtubule disruptors

Leese, M. P., Jourdan, F. L., Major, M. R., Dohle, W., Hamel, E., Ferrandis, E., Fiore, A., Kasprzyk, P. G. & Potter, B. V. L., Jan 2014, In : ChemMedChem. 9, 1, p. 85-108 24 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The enzymes of human diphosphoinositol polyphosphate metabolism

Thomas, M. P. & Potter, B. V. L., Jan 2014, In : FEBS Journal. 281, 1, p. 14-33 20 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2015

Calcium Signalling Triggered by NAADP in T Cells Determines Cell Shape and Motility During Immune Synapse Formation

Nebel, M., Zhang, B., Odoardi, F., Flugel, A., Potter, B. & Guse, A. H., 2015, In : Messenger. 4, 1, p. 104-111

Research output: Contribution to journalArticle

Open Access
File
117 Downloads (Pure)