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Author

  • Laurence Hurst
2011

Atypical AT skew in firmicute genomes results from selection and not from mutation

Charneski, C. A., Honti, F., Bryant, J. M., Hurst, L. D. & Feil, E. J., 15 Sep 2011, In : Plos Genetics. 7, 9, 14 p., e1002283.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Birt Hogg-Dube Syndrome-Associated FLCN Mutations Disrupt Protein Stability

Nahorski, M. S., Reiman, A., Lim, D. H. K., Nookala, R. K., Seabra, L., Lu, X. H., Fenton, J., Boora, U., Nordenskjold, M., Latif, F., Hurst, L. D. & Maher, E. R., Aug 2011, In : Human Mutation. 32, 8, p. 921-929 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

Garfield, A. S., Cowley, M., Smith, F. M., Moorwood, K., Stewart-Cox, J. E., Gilroy, K., Baker, S., Xia, J., Dalley, J. W., Hurst, L. D., Wilkinson, L. S., Isles, A. R. & Ward, A., 27 Jan 2011, In : Nature. 469, 7331, p. 534-538 5 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)

Error prevention and mitigation as forces in the evolution of genes and genomes

Warnecke, T. & Hurst, L. D., Dec 2011, In : Nature Reviews Genetics. 12, 12, p. 875-881 7 p.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
133 Downloads (Pure)
4 Citations (Scopus)

Metabolic trade-offs and the maintenance of the fittest and the flattest

Beardmore, R. E., Gudelj, I., Lipson, D. A. & Hurst, L. D., 21 Apr 2011, In : Nature. 472, 7343, p. 342-346 5 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Molecular genetics: The sound of silence

Hurst, L. D., 31 Mar 2011, In : Nature. 471, 7340, p. 582-583 2 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
40 Citations (Scopus)
File
38 Citations (Scopus)
111 Downloads (Pure)
2012

Competition between transposable elements and mutator genes in bacteria

Feher, T., Bogos, B., Mehi, O., Fekete, G., Csorgo, B., Kovacs, K., Posfai, G., Papp, B., Hurst, L. D. & Pal, C., 1 Oct 2012, In : Molecular Biology and Evolution. 29, 10, p. 3153-3159

Research output: Contribution to journalArticle

21 Citations (Scopus)

Direct and indirect consequences of meiotic recombination: Implications for genome evolution

Webster, M. T. & Hurst, L. D., Mar 2012, In : Trends in Genetics. 28, 3, p. 101-109 9 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Great majority of recombination events in Arabidopsis are gene conversion events

Yang, S., Yuan, Y., Wang, L., Li, J., Wang, W., Liu, H., Chen, J., Hurst, L. D. & Tian, D., 18 Dec 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 51, p. 20992-20997 6 p.

Research output: Contribution to journalArticle

Open Access
File
50 Citations (Scopus)
93 Downloads (Pure)

Late-replicating domains have higher divergence and diversity in Drosophila melanogaster

Weber, C. C., Pink, C. J. & Hurst, L. D., Feb 2012, In : Molecular Biology and Evolution. 29, 2, p. 873-882 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Young intragenic miRNAs are less coexpressed with host genes than old ones: Implications of miRNA-host gene coevolution

He, C., Li, Z., Chen, P., Huang, H., Hurst, L. D. & Chen, J., 2012, In : Nucleic Acids Research. 40, 9, p. 4002-4012 11 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2013

Duplication and retention biases of essential and non-essential genes revealed by systematic knockdown analyses

Woods, S., Coghlan, A., Rivers, D., Warnecke, T., Jeffries, S. J., Kwon, T., Rogers, A., Hurst, L. & Ahringer, J., 9 May 2013, In : Plos Genetics. 9, 5, e1003330.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Evidence for deep phylogenetic conservation of exonic splice-related constraints: Splice-related skews at exonic ends in the brown alga Ectocarpus are common and resemble those seen in humans

Wu, X., Tronholm, A., Fernandez Cáceres, E., Tovar-Corona, J. M., Chen, L., Urrutia, A. O. & Hurst, L. D., 2013, In : Genome biology and evolution. 5, 9, p. 1731-1745 15 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
121 Downloads (Pure)
56 Citations (Scopus)

Open questions: A logic (or lack thereof) of genome organization

Hurst, L. D., 28 May 2013, In : BMC Biology. 11, 58.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Positively charged residues are the major determinants of ribosomal velocity

Charneski, C. A. & Hurst, L. D., 12 Mar 2013, In : PLoS Biology. 11, 3, e1001508.

Research output: Contribution to journalArticle

139 Citations (Scopus)

The form of a trade-off determines the response to competition

Maharjan, R., Nilsson, S., Sung, J., Haynes, K., Beardmore, R. E., Hurst, L. D., Ferenci, T. & Gudelj, I., Oct 2013, In : Ecology Letters. 16, 10, p. 1267-1276 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2014

A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators

Hurst, L. D., Sachenkova, O., Daub, C., Forrest, A. R. R. & Huminiecki, L., 31 Jul 2014, In : Genome Biology. 15, 7, 413.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Environmentally responsive genome-wide accumulation of de novo Arabidopsis thaliana mutations and epimutations

Jiang, C., Mithani, A., Belfield, E. J., Mott, R., Hurst, L. D. & Harberd, N. P., 1 Nov 2014, In : Genome Research. 24, 11, p. 1821-1829 9 p.

Research output: Contribution to journalArticle

Open Access
75 Citations (Scopus)

Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients

Yin, S., Yang, J., Lin, B., Deng, W., Zhang, Y., Yi, X., Shi, Y., Tao, Y., Cai, J., Wu, C-I., Zhao, G., Hurst, L. D., Zhang, J., Hu, L. & Kong, X., 12 Aug 2014, In : Scientific Reports. 4, 6036.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
120 Downloads (Pure)

Positive charge loading at protein termini is due to membrane protein topology, not a translational ramp

Charneski, C. A. & Hurst, L. D., Jan 2014, In : Molecular Biology and Evolution. 31, 1, p. 70-84 15 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
139 Downloads (Pure)

Predicting the virulence of MRSA from its genome sequence

Laabei, M., Recker, M., Rudkin, J. K., Aldeljawi, M., Gulay, Z., Sloan, T. J., Williams, P., Endres, J. L., Bayles, K. W., Fey, P. D., Yajjala, V. K., Widhelm, T., Hawkins, E., Lewis, K., Parfett, S., Scowen, L., Peacock, S. J., Holden, M., Wilson, D., Read, T. D. & 6 others, Van Den Elsen, J., Priest, N. K., Feil, E. J., Hurst, L. D., Josefsson, E. & Massey, R. C., 1 May 2014, In : Genome Research. 24, 5, p. 839-849 11 p.

Research output: Contribution to journalArticle

Open Access
80 Citations (Scopus)
59 Downloads (Pure)

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

Wang, J., Xie, G., Singh, M., Tashakkori Ghanbarian, A., Raskó, T., Szvetnik, A., Cai, H., Besser, D., Prigione, A., Fuchs, N. V., Schumann, G. G., Chen, W., Lorincz, M. C., Ivics, Z., Hurst, L. D. & Izsvák, Z., 18 Dec 2014, In : Nature. 516, 7531, p. 405-409 5 p.

Research output: Contribution to journalArticle

Open Access
File
178 Citations (Scopus)
227 Downloads (Pure)

Purifying selection on splice-related motifs, not expression level nor RNA folding, explains nearly all constraint on human lincRNAs

Schüler, A., Ghanbarian, A. T. & Hurst, L. D., 1 Dec 2014, In : Molecular Biology and Evolution. 31, 12, p. 3164-3183 20 p.

Research output: Contribution to journalArticle

Open Access
26 Citations (Scopus)
2015

Genomic analysis of isolates from the United Kingdom 2012 pertussis outbreak reveals that vaccine antigen genes are unusually fast evolving

Sealey, K. L., Harris, S. R., Fry, N. K., Hurst, L. D., Gorringe, A. R., Parkhill, J. & Preston, A., 15 Jul 2015, In : Journal of Infectious Diseases. 212, 2, p. 294-301 8 p.

Research output: Contribution to journalArticle

Open Access
File
42 Citations (Scopus)
133 Downloads (Pure)

Neighboring genes show correlated evolution in gene expression

Ghanbarian, A. T. & Hurst, L. D., Jul 2015, In : Molecular Biology and Evolution. 32, 7, p. 1748-1766

Research output: Contribution to journalArticle

48 Citations (Scopus)

Parent-progeny sequencing indicates higher mutation rates in heterozygotes

Yang, S., Wang, L., Huang, J., Zhang, X., Yuan, Y., Chen, J. Q., Hurst, L. D. & Tian, D., 23 Jul 2015, In : Nature. 523, 7561, p. 463-467 5 p.

Research output: Contribution to journalArticle

Open Access
File
67 Citations (Scopus)
191 Downloads (Pure)

The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome

the FANTOM consortium & Huminiecki, L., 31 Dec 2015, In : PLoS Biology. 13, 12, p. 1-48 48 p., e1002315.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)
46 Downloads (Pure)
File
14 Citations (Scopus)
87 Downloads (Pure)
2016
Open Access
File
23 Citations (Scopus)
125 Downloads (Pure)

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression

Wang, J., Singh, M., Sun, C., Besser, D., Prigione, A., Ivics, Z., Hurst, L. D. & Izsvák, Z., 1 Feb 2016, In : Nature Protocols. 11, 2, p. 327-346 20 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Mutation rate analysis via parent– progeny sequencing of the perennial peach. I. A low rate in woody perennials and a higher mutagenicity in hybrids

Xie, Z., Wang, L., Wang, L., Wang, Z., Lu, Z., Tian, D., Yang, S. & Hurst, L. D., 26 Oct 2016, In : Proceedings of the Royal Society B: Biological Sciences. 283, 1841, 20161016.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
112 Downloads (Pure)

Mutation rate analysis via parent- progeny sequencing of the perennial peach. II. No evidence for recombination associated mutation

Wang, L., Zhang, Y., Qin, C., Tian, D., Yang, S. & Hurst, L. D., 26 Oct 2016, In : Proceedings of the Royal Society B: Biological Sciences. 283, 1841, 20161785.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
121 Downloads (Pure)

Pluripotency and the endogenous retrovirus HERVH: conflict or serendipity?

Izsvák, Z., Wang, J., Singh, M., Mager, D. L. & Hurst, L. D., 1 Jan 2016, In : Bioessays. 38, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Purifying selection on exonic splice enhancers in intronless genes

Savisaar, R. & Hurst, L. D., Jun 2016, In : Molecular Biology and Evolution. 33, 6, p. 1396-1418

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
129 Downloads (Pure)

Why did sex evolve? Researchers edge closer to solving longstanding mystery

Hurst, L., 29 Feb 2016, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access

Why is the X chromosome so odd? Traffic analogy helped us crack the mystery

Hurst, L. D. & Huminiecki, L., 11 Jan 2016, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access
2017
Open Access
3 Citations (Scopus)

Both maintenance and avoidance of RNA-binding protein interactions constrain coding region evolution

Savisaar, R. & Hurst, L., 1 May 2017, In : Molecular Biology and Evolution. 34, 5, p. 1110-1126

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
154 Downloads (Pure)

Comparative analyses of selection operating on non-translated intergenic regions of diverse bacterial species

Thorpe, H. A., Bayliss, S. C., Hurst, L. D. & Feil, E. J., 5 May 2017, In : Genetics. 206, 1, p. 363-376 195784.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Depletion of somatic mutations in splicing-associated sequences in cancer genomes

Hurst, L. & Batada, N. N., 7 Nov 2017, In : Genome Biology. 18, 1, 12 p., 213.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Direct determination of the mutation rate in the bumblebee reveals evidence for weak recombination-associated mutation and an approximate rate constancy in insects

Liu, H., Jia, Y., Sun, X., Tian, D., Hurst, L. D. & Yang, S., 1 Jan 2017, In : Molecular Biology and Evolution. 34, 1, p. 119-130 12 p.

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker

Zadora, J., Singh, M., Herse, F., Przybyl, L., Haasse, N., Golic, M., Yung, H. W., Huppertz, B., Cartwright, J. E., Whitley, G., Johnsen, G. M., Levi, G., Isbruch, A., Schulz, H., Luft, F. C., Muller, D. N., Staff, A. C., Hurst, L., Dechend, R. & Izsvak, Z., 7 Nov 2017, In : Circulation. 136, 19, p. 1824-1839 16 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids

Thumann, G., Harmening, N., Prat-Souteyrand, C., Marie, C., Pastor, M., Sebe, A., Miskey, C., Hurst, L. D., Diarra, S., Kropp, M., Walter, P., Scherman, D., Ivics, Z., Izsvák, Z. & Johnen, S., 17 Mar 2017, In : Molecular Therapy - Nucleic Acids. 6, p. 302-314 13 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Estimating the prevalence of functional exonic splice regulatory information

Savisaar, R. & Hurst, L. D., 1 Sep 2017, In : Human Molecular Genetics. 136, 9, p. 1059-1078 20 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Male Mutation Bias Is the Main Force Shaping Chromosomal Substitution Rates in Monotreme Mammals

Link, V., Aguilar-Gómez, D., Ramírez-Suástegui, C., Hurst, L. D. & Cortez, D., 1 Sep 2017, In : Genome biology and evolution. 9, 9, p. 2198-2210 13 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Teaching genetics prior to teaching evolution improves evolution understanding but not acceptance

Mead, R., Hejmadi, M. & Hurst, L. D., 31 May 2017, In : PLoS Biology. 15, 5, e2002255.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)