8.29 Spectroscopic analysis: diastereomeric derivatization for spectroscopy

M. E. Powell, C. D. Evans, S. D. Bull, T. D. James, P. S. Fordred

Research output: Chapter or section in a book/report/conference proceedingChapter or section

9 Citations (SciVal)


Chirality plays a central role in the world around us, with nature and scientists producing an ever-increasing number of chiral molecules that have a wide range of different applications. The word chirality is used as a term to describe a molecule whose enantiomers are non-superimposable on their mirror images. A chiral molecule that contains a single stereogenic center may exist in an enantiopure form or as a mixture of enantiomers in varying ratios. Enantiomers exhibit identical physical and chemical properties when present in an achiral environment; however, they often behave very differently when placed in a chiral environment. Many biologically active molecules such as proteins, nucleic acids, and sugars are chiral biopolymers that are constructed from homochiral building blocks.

Original languageEnglish
Title of host publicationComprehensive Chirality
Subtitle of host publicationVolume 8 - Separations and Analysis
EditorsE. M. Carreira, H. Yamamoto
Place of PublicationLondon, U. K.
Number of pages29
ISBN (Print)9780080951683
Publication statusPublished - Sept 2012


  • Absolute configuration
  • Chiral derivatizing agent
  • Diastereomeric ratio
  • Enantiomeric excess
  • NMR spectroscopic analysis


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