Abstract
| Language | English |
|---|---|
| Pages | 555-557 |
| Number of pages | 3 |
| Journal | Nature Chemical Biology |
| Volume | 11 |
| Issue number | 8 |
| Early online date | 22 Jun 2015 |
| DOIs | |
| Status | Published - Aug 2015 |
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5-Formylcytosine can be a stable DNA modification in mammals. / Bachman, Martin; Uribe-Lewis, Santiago; Yang, Xiaoping; Burgess, Heather E.; Iurlaro, Mario; Reik, Wolf; Murrell, Adele; Balasubramanian, Shankar.
In: Nature Chemical Biology, Vol. 11, No. 8, 08.2015, p. 555-557.Research output: Contribution to journal › Article
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TY - JOUR
T1 - 5-Formylcytosine can be a stable DNA modification in mammals
AU - Bachman, Martin
AU - Uribe-Lewis, Santiago
AU - Yang, Xiaoping
AU - Burgess, Heather E.
AU - Iurlaro, Mario
AU - Reik, Wolf
AU - Murrell, Adele
AU - Balasubramanian, Shankar
PY - 2015/8
Y1 - 2015/8
N2 - 5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable isotope labeling in vivo, we show that 5fC can be a stable DNA modification. These results suggest that 5fC has functional roles in DNA that go beyond being a demethylation intermediate.
AB - 5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable isotope labeling in vivo, we show that 5fC can be a stable DNA modification. These results suggest that 5fC has functional roles in DNA that go beyond being a demethylation intermediate.
UR - http://dx.doi.org/10.1038/nchembio.1848
U2 - 10.1038/nchembio.1848
DO - 10.1038/nchembio.1848
M3 - Article
VL - 11
SP - 555
EP - 557
JO - Nature Chemical Biology
T2 - Nature Chemical Biology
JF - Nature Chemical Biology
SN - 1552-4450
IS - 8
ER -