5-Formylcytosine can be a stable DNA modification in mammals

Martin Bachman, Santiago Uribe-Lewis, Xiaoping Yang, Heather E. Burgess, Mario Iurlaro, Wolf Reik, Adele Murrell, Shankar Balasubramanian

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5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable isotope labeling in vivo, we show that 5fC can be a stable DNA modification. These results suggest that 5fC has functional roles in DNA that go beyond being a demethylation intermediate.
Original languageEnglish
Pages (from-to)555-557
Number of pages3
JournalNature Chemical Biology
Issue number8
Early online date22 Jun 2015
Publication statusPublished - 13 Aug 2015


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