Abstract
5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable isotope labeling in vivo, we show that 5fC can be a stable DNA modification. These results suggest that 5fC has functional roles in DNA that go beyond being a demethylation intermediate.
Original language | English |
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Pages (from-to) | 555-557 |
Number of pages | 3 |
Journal | Nature Chemical Biology |
Volume | 11 |
Issue number | 8 |
Early online date | 22 Jun 2015 |
DOIs | |
Publication status | Published - 13 Aug 2015 |
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Adele Murrell
- Department of Life Sciences - Professor
- Centre for Therapeutic Innovation
- Centre for Mathematical Biology - Co-Director
- Centre for Bioengineering & Biomedical Technologies (CBio)
Person: Research & Teaching, Affiliate staff