2D and 3D electrospinning technologies for the fabrication of nanofibrous scaffolds for skin tissue engineering: A review

Antonios Keirouz, Michael Chung, Jaehoon Kwon, Giuseppino Fortunato, Norbert Radacsi

Research output: Contribution to journalReview articlepeer-review

165 Citations (SciVal)


This review provides insights into the current advancements in the field of electrospinning, focusing on its applications for skin tissue engineering. Furthermore, it reports the evolvement and present challenges of advanced skin substitute product development and explores the recent contributions in 2D and 3D scaffolding, focusing on natural, synthetic, and composite nanomaterials. In the past decades, nanotechnology has arisen as a fascinating discipline that has influenced every aspect of science, engineering, and medicine. Electrospinning is a versatile fabrication method that allows researchers to elicit and explore many of the current challenges faced by tissue engineering and regenerative medicine. In skin tissue engineering, electrospun nanofibers are particularly attractive due to their refined morphology, processing flexibility—that allows for the formation of unique materials and structures, and its extracellular matrix-like biomimetic architecture. These allow for electrospun nanofibers to promote improved re-epithelization and neo-tissue formation of wounds. Advancements in the use of portable electrospinning equipment and the employment of electrospinning for transdermal drug delivery and melanoma treatment are additionally explored. Present trends and issues are critically discussed based on recently published patents, clinical trials, and in vivo studies. This article is categorized under: Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Therapeutic Approaches and Drug Discovery > Emerging Technologies Implantable Materials and Surgical Technologies > Nanomaterials and Implants.

Original languageEnglish
Article numbere1626
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Issue number4
Publication statusPublished - 1 Jul 2020

Bibliographical note

Funding Information:
The authors would like to thank the Nanomaterials Laboratory of the Engineering School at the University of Edinburgh, UK, and the Laboratory for Biomimetic Membranes and Textiles at Empa, St. Gallen, Switzerland. Further, the authors would like to express their gratitude to Nanomedic for allowing us to reuse some of the patient images obtained during the Spincare2? clinical trial (NCT02997592) on the review article. We would further like to thank the Mayo Foundation for Medical Education and Research for permitting us to use an illustration and the reviewers' for their valuable inputs.

Publisher Copyright:
© 2020 Wiley Periodicals, Inc.

Copyright 2020 Elsevier B.V., All rights reserved.


  • electrospinning
  • portable electrospinning
  • three-dimensional
  • tissue engineering
  • wound healing

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering


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