2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity

Mathew P. Leese; Bertrand Leblond; Andrew Smith; Simon P. Newman; Anna Di Fiore; Giuseppina De Simone; Cladiu T. Supuran; Atul Purohit; Michael J. Reed; Barry V. L. Potter

doi:10.1021/jm060705x

2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity

Mathew P. Leese
, Bertrand Leblond
, Andrew Smith
, Simon P. Newman
, Anna Di Fiore
, Giuseppina De Simone
, Cladiu T. Supuran
, Atul Purohit
, Michael J. Reed
, Barry V. L. Potter

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

108 Citations (SciVal)

Original language	English
Pages (from-to)	7683-7696
Journal	Journal of Medicinal Chemistry
Volume	49
Issue number	26
DOIs	https://doi.org/10.1021/jm060705x
Publication status	Published - 2006

Keywords

in vitro

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10.1021/jm060705x

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Leese, M. P., Leblond, B., Smith, A., Newman, S. P., Di Fiore, A., De Simone, G., Supuran, C. T., Purohit, A., Reed, M. J., & Potter, B. V. L. (2006). 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. Journal of Medicinal Chemistry, 49(26), 7683-7696. https://doi.org/10.1021/jm060705x

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title = "2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity",

keywords = "in vitro",

author = "Leese, \{Mathew P.\} and Bertrand Leblond and Andrew Smith and Newman, \{Simon P.\} and \{Di Fiore\}, Anna and \{De Simone\}, Giuseppina and Supuran, \{Cladiu T.\} and Atul Purohit and Reed, \{Michael J.\} and Potter, \{Barry V. L.\}",

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doi = "10.1021/jm060705x",

language = "English",

volume = "49",

pages = "7683--7696",

journal = "Journal of Medicinal Chemistry",

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T1 - 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents

T2 - synthesis, in vitro SAR, protein crystallography, and in vivo activity

AU - Leese, Mathew P.

AU - Leblond, Bertrand

AU - Smith, Andrew

AU - Newman, Simon P.

AU - Di Fiore, Anna

AU - De Simone, Giuseppina

AU - Supuran, Cladiu T.

AU - Purohit, Atul

AU - Reed, Michael J.

AU - Potter, Barry V. L.

PY - 2006

Y1 - 2006

KW - in vitro

UR - http://dx.doi.org/10.1021/jm060705x

U2 - 10.1021/jm060705x

DO - 10.1021/jm060705x

M3 - Article

SN - 0022-2623

VL - 49

SP - 7683

EP - 7696

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 26

ER -

2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity

Keywords

Access to Document

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