2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity

Mathew P. Leese; Bertrand Leblond; Andrew Smith; Simon P. Newman; Anna Di Fiore; Giuseppina De Simone; Cladiu T. Supuran; Atul Purohit; Michael J. Reed; Barry V. L. Potter

doi:10.1021/jm060705x

2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity

Mathew P. Leese, Bertrand Leblond, Andrew Smith, Simon P. Newman, Anna Di Fiore, Giuseppina De Simone, Cladiu T. Supuran, Atul Purohit, Michael J. Reed, Barry V. L. Potter

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

16 Citations (SciVal)

Original language	English
Pages (from-to)	7683-7696
Journal	Journal of Medicinal Chemistry
Volume	49
Issue number	26
DOIs	https://doi.org/10.1021/jm060705x
Publication status	Published - 2006

Keywords

in vitro

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10.1021/jm060705x

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Leese, M. P., Leblond, B., Smith, A., Newman, S. P., Di Fiore, A., De Simone, G., Supuran, C. T., Purohit, A., Reed, M. J., & Potter, B. V. L. (2006). 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. Journal of Medicinal Chemistry, 49(26), 7683-7696. https://doi.org/10.1021/jm060705x

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author = "Leese, {Mathew P.} and Bertrand Leblond and Andrew Smith and Newman, {Simon P.} and {Di Fiore}, Anna and {De Simone}, Giuseppina and Supuran, {Cladiu T.} and Atul Purohit and Reed, {Michael J.} and Potter, {Barry V. L.}",

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T1 - 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents

T2 - synthesis, in vitro SAR, protein crystallography, and in vivo activity

AU - Leese, Mathew P.

AU - Leblond, Bertrand

AU - Smith, Andrew

AU - Newman, Simon P.

AU - Di Fiore, Anna

AU - De Simone, Giuseppina

AU - Supuran, Cladiu T.

AU - Purohit, Atul

AU - Reed, Michael J.

AU - Potter, Barry V. L.

PY - 2006

Y1 - 2006

KW - in vitro

UR - http://dx.doi.org/10.1021/jm060705x

U2 - 10.1021/jm060705x

DO - 10.1021/jm060705x

M3 - Article

VL - 49

SP - 7683

EP - 7696

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 26

ER -

2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity

Keywords

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