1,4-Oxazines, 1,4-benzoxazines and reduced forms

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter deals with the new chemistry that is exemplified on the use of morpholines as enamine precursors. A very large literature relating to the medicinal and industrial applications of morpholine derivatives is not covered in this chapter. The review of 1, 4-oxazinones describes the presence of the halogen substituent at C-5 seems important, and the addition occurs with both electron-rich and electron-poor alkenes. For symmetrically substituted alkenes there is preference for formation of the endo configured adducts. As an illustration, the chiral morpholines are available through the intermolecular cyclisation of allylic amines. Here the reactions are mediated by palladium and can be made catalytic by adding a small amount of trifluoroacetic acid to the reagent system. The reactions of morpholines are explained with structure diagrams, equations and examples. The synthesis, reactions and derivatives of the compounds containing phenoxazines and phenoxazinones are presented.
Original languageEnglish
Title of host publicationSecond Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds
Subtitle of host publicationA Modern Comprehensive Treatise
Pages465-511
Number of pages47
Volume4
Edition2
DOIs
Publication statusPublished - 1991

Fingerprint Dive into the research topics of '1,4-Oxazines, 1,4-benzoxazines and reduced forms'. Together they form a unique fingerprint.

  • Cite this

    Sainsbury, M. (1991). 1,4-Oxazines, 1,4-benzoxazines and reduced forms. In Second Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds: A Modern Comprehensive Treatise (2 ed., Vol. 4, pp. 465-511) https://doi.org/10.1016/B978-044453347-0.50212-3