@inbook{89d9e53f9caf4e6e84558f71a161c529,
title = "14-amino-4,5-epoxymorphinan derivatives and their pharmacological actions",
abstract = "14-Hydroxy-7,8-dihydromorphinone (oxymorphone) and its derivatives (oxycodone, naloxone, naltrexone) have become among the most important clinical agents to have been produced from opium. 14-Aminocodeinone and its 7,8-dihydro and morphinone derivatives are of more recent origin thanks to the work of Professor Gordon Kirby and his collaborators. The 14-amino parent compounds have proved of limited interest but their 14-acylamino- and 14-alkylamino derivatives have been extensively studied. The 4′ -substituted cinnamoylamino-17-cyclopropylmethyl-7,8-dihydronormorphinones, C-CAM and M-CAM are the best available selective MOR irreversible antagonists and the related dihydrocodeinone MC-CAM, 4′-chlorocinnamoylamino-17-cyclopropylmethyl-7,8- dihydronorcodeinone, is a long-acting MOR partial agonist with extended MOR-pseudoirreversible antagonist activity that could be a candidate for pharmacotherapy of opiate abuse/dependence.",
keywords = "Agonist, Antagonist, Epoxymorphinan, MOR, Opioid",
author = "Lewis, {John W.} and Husbands, {Stephen M.}",
year = "2011",
month = feb,
day = "4",
doi = "10.1007/128_2010_89",
language = "English",
isbn = "9783642181061",
series = "Topics in Current Chemistry",
publisher = "Springer Berlin Heidelberg",
pages = "93--119",
editor = "Hiroshi Nagase",
booktitle = "Chemistry of Opioids",
address = "Germany",
}