1,1-Diacyloxy-1-phenylmethanes as versatile N-acylating agents for amines

Robert S.L. Chapman; Joshua D. Tibbetts; Steven D. Bull

doi:10.1016/j.tet.2018.05.044

1,1-Diacyloxy-1-phenylmethanes as versatile N-acylating agents for amines

Robert S.L. Chapman, Joshua D. Tibbetts, Steven D. Bull

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Abstract

1,1-Diacyloxy-1-phenylmethanes and 1-pivaloxy-1-acyloxy-1-phenylmethanes have been used as bench stable N-acylating reagents for primary and secondary amines and anilines under solvent-free conditions to afford their corresponding amides in good yield.

Original language	English
Pages (from-to)	5330-5339
Number of pages	10
Journal	Tetrahedron
Volume	74
Issue number	38
Early online date	21 May 2018
DOIs	https://doi.org/10.1016/j.tet.2018.05.044
Publication status	Published - 20 Sept 2018

Funding

We thank the EPSRC and the Centre for Doctoral Training in Sustainable Chemical Technologies ( EP/L016354/1 ) for funding. Appendix A

Keywords

1,1-Acylals
Amides
N-Acylation
Solvent free

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2018.05.044

1,1-Diacyloxy-1-Phenylmethanes as Versatile N-Acylating Agents for AminesAccepted author manuscript, 1.01 MBLicence: CC BY-NC-ND

Cite this

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title = "1,1-Diacyloxy-1-phenylmethanes as versatile N-acylating agents for amines",

abstract = "1,1-Diacyloxy-1-phenylmethanes and 1-pivaloxy-1-acyloxy-1-phenylmethanes have been used as bench stable N-acylating reagents for primary and secondary amines and anilines under solvent-free conditions to afford their corresponding amides in good yield.",

keywords = "1,1-Acylals, Amides, N-Acylation, Solvent free",

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AU - Chapman, Robert S.L.

AU - Tibbetts, Joshua D.

AU - Bull, Steven D.

PY - 2018/9/20

Y1 - 2018/9/20

N2 - 1,1-Diacyloxy-1-phenylmethanes and 1-pivaloxy-1-acyloxy-1-phenylmethanes have been used as bench stable N-acylating reagents for primary and secondary amines and anilines under solvent-free conditions to afford their corresponding amides in good yield.

AB - 1,1-Diacyloxy-1-phenylmethanes and 1-pivaloxy-1-acyloxy-1-phenylmethanes have been used as bench stable N-acylating reagents for primary and secondary amines and anilines under solvent-free conditions to afford their corresponding amides in good yield.

KW - 1,1-Acylals

KW - Amides

KW - N-Acylation

KW - Solvent free

UR - http://www.scopus.com/inward/record.url?scp=85048338873&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2018.05.044

DO - 10.1016/j.tet.2018.05.044

M3 - Article

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SN - 0040-4020

VL - 74

SP - 5330

EP - 5339

JO - Tetrahedron

JF - Tetrahedron

IS - 38

ER -

1,1-Diacyloxy-1-phenylmethanes as versatile N-acylating agents for amines

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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Avance 300 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

Electrospray Time-of-Flight Mass Spectrometer (Open-Access)

Propulse 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

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1,1-Diacyloxy-1-phenylmethanes as versatile N-acylating agents for amines

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Equipment

Avance 300 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

Electrospray Time-of-Flight Mass Spectrometer (Open-Access)

Propulse 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

Cite this