1,1-Diacyloxy-1-phenylmethanes as versatile N-acylating agents for amines

Robert S.L. Chapman, Joshua D. Tibbetts, Steven D. Bull

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
40 Downloads (Pure)


1,1-Diacyloxy-1-phenylmethanes and 1-pivaloxy-1-acyloxy-1-phenylmethanes have been used as bench stable N-acylating reagents for primary and secondary amines and anilines under solvent-free conditions to afford their corresponding amides in good yield.

Original languageEnglish
Pages (from-to)5330-5339
Number of pages10
Issue number38
Early online date21 May 2018
Publication statusPublished - 20 Sep 2018


  • 1,1-Acylals
  • Amides
  • N-Acylation
  • Solvent free

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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