1,1-Diacyloxy-1-phenylmethanes as versatile N-acylating agents for amines

Robert S.L. Chapman; Joshua D. Tibbetts; Steven D. Bull

doi:10.1016/j.tet.2018.05.044

1,1-Diacyloxy-1-phenylmethanes as versatile N-acylating agents for amines

Robert S.L. Chapman, Joshua D. Tibbetts, Steven D. Bull

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Abstract

1,1-Diacyloxy-1-phenylmethanes and 1-pivaloxy-1-acyloxy-1-phenylmethanes have been used as bench stable N-acylating reagents for primary and secondary amines and anilines under solvent-free conditions to afford their corresponding amides in good yield.

Original language	English
Pages (from-to)	5330-5339
Number of pages	10
Journal	Tetrahedron
Volume	74
Issue number	38
Early online date	21 May 2018
DOIs	https://doi.org/10.1016/j.tet.2018.05.044
Publication status	Published - 20 Sept 2018

Keywords

1,1-Acylals
Amides
N-Acylation
Solvent free

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2018.05.044

1,1-Diacyloxy-1-Phenylmethanes as Versatile N-Acylating Agents for AminesAccepted author manuscript, 1.01 MBLicence: CC BY-NC-ND

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abstract = "1,1-Diacyloxy-1-phenylmethanes and 1-pivaloxy-1-acyloxy-1-phenylmethanes have been used as bench stable N-acylating reagents for primary and secondary amines and anilines under solvent-free conditions to afford their corresponding amides in good yield.",

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AU - Tibbetts, Joshua D.

AU - Bull, Steven D.

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Y1 - 2018/9/20

N2 - 1,1-Diacyloxy-1-phenylmethanes and 1-pivaloxy-1-acyloxy-1-phenylmethanes have been used as bench stable N-acylating reagents for primary and secondary amines and anilines under solvent-free conditions to afford their corresponding amides in good yield.

AB - 1,1-Diacyloxy-1-phenylmethanes and 1-pivaloxy-1-acyloxy-1-phenylmethanes have been used as bench stable N-acylating reagents for primary and secondary amines and anilines under solvent-free conditions to afford their corresponding amides in good yield.

KW - 1,1-Acylals

KW - Amides

KW - N-Acylation

KW - Solvent free

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ER -

1,1-Diacyloxy-1-phenylmethanes as versatile N-acylating agents for amines

Abstract

Keywords

ASJC Scopus subject areas

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