Abstract
Chiral molecules play a central role in the world around us, with an ever-increasing number of chiral molecules with varied applications requiring readily available methods for determining their enantiopurity and absolute configuration. This article focuses on chiral derivatization agents (CDAs) for use in NMR spectroscopy, which provide cheap, practical, and reliable methods for chiral analysis. The general principles of CDA methodologies will be presented, with a focus on CDAs that have been developed for analyzing the enantiopurities and absolute configurations of chiral compounds that contain commonly encountered functional groups.
| Original language | English |
|---|---|
| Title of host publication | Comprehensive Chirality (2nd ed.) |
| Subtitle of host publication | Volume 1-10 |
| Place of Publication | Netherlands |
| Publisher | Elsevier |
| Pages | 593-631 |
| Number of pages | 39 |
| ISBN (Electronic) | 9780323906456 |
| ISBN (Print) | 9780323906449 |
| DOIs | |
| Publication status | Published - 24 May 2024 |
Keywords
- Absolute configuration
- Chiral derivatizing agent
- Competing enantioselective conversion
- Diastereomeric ratio
- Enantiomeric excess
- NMR spectroscopic analysis
ASJC Scopus subject areas
- General Chemistry
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