α-Synuclein as a ferrireductase

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Many proteins associated with neurodegenerative diseases have poorly defined or unknown functions. α-Synuclein is one such protein which is associated with a range of diseases including Parkinson's disease. Now accepted as a metal-binding protein, α-synuclein's function could possibly be defined in relation to the binding of cofactors. It has been suggested recently that α-synuclein is able to reduce iron using copper as its catalytic centre. The consequence of this is that possibly the function of α-synuclein can now be defined. The evidence for this and the consequences for Parkinson's disease are discussed in the present review.
Original languageEnglish
Pages (from-to)1513-1517
Number of pages5
JournalBiochemical Society Transactions
Volume41
Issue number6
DOIs
Publication statusPublished - Dec 2013

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