Cutaneous squamous cell carcinoma (cSCC) accounts for the majority of deaths associated with non-melanoma skin cancers. The powerful transcriptional regulator proteins YAP and TAZ have recently surfaced as essential drivers of tumour initiation, progression and metastasis in many different cancer types, including cSCC. YAP/TAZ are required in cSCC but not for normal epidermal homeostasis. Since all upstream regulators ultimately impact on YAP/TAZ nuclear availability and transcriptional responses, the nuclear mechanisms by which YAP/TAZ select their downstream transcriptional programmes and transcriptional partners thus represent so far underestimated opportunities for therapeutic intervention in cSCC and other cancer types.
|Effective start/end date||1/12/18 → 30/11/19|