Targeting AMACR to Treat Castrate Resistant Prostate Cancer

Project: UK charity

Project Details

StatusFinished
Effective start/end date5/10/1131/01/15

Funding

  • Prostate Cancer UK

Research Output

Identification of novel small-molecule inhibitors of α-methylacyl-CoA racemase (AMACR; P504S) and structure-activity relationships

Petrova, Y., Wadda, K., Nathubhai, A., Jevglevskis, M., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103264.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents

Jevglevskis, M., Nathubhai, A., Wadda, K., Lee, G. L., Al-Rawi, S., Jiao, T., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103263.

Research output: Contribution to journalArticle

Open Access
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66 Downloads (Pure)

A convenient colorimetric assay for α-methylacyl-CoA racemase (AMACR; P504S) and testing of inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 21 Apr 2017, (Unpublished).

Research output: Contribution to conferenceAbstract

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