Revealing insulin-sensitive glucose uptake at single molecule resolution using cryo-EM.

The aim is to investigate the molecular mechanisms underpinning the process of entry of glucose into adipose and muscle cells. This is important as a better understanding of this will help us develop interventions/strategies to treat chronic health conditions such as obesity and type 2 diabetes in which glucose uptake by peripheral tissues is impaired. More precisely, this pilot study will explore the feasibility of using a state-of-the-art technique available in our GW4 community, the cryo-electron microscope (cryo-EM).