REGULATION OF THE HUMAN HEME OXYGENASE 1 GENE BY SOLAR UVA R ADIATION - A POTENTIAL ROLE FOR BACH PROTEINS AND HEME TURNO

Project: Research council

Project Details

Description

Repeated acute (e.g. sunburn) or chronic inflammatory events can lead to permanent tissue damage and disease so that agents which suppress inflammation are used to treat disease. Among the body’s own anti-inflammatory proteins is heme oxygenase 1 which is induced in many types of tissue following damage, including damage by the ultraviolet A component of sunlight. The protein is able to break down heme, a molecule which can have damaging side-effects when in excess and unbound to protein. Understanding how this protein is regulated and how it is able to protect cells and tissues should provide information of value in treating inflammatory disease. We intend to use cells derived and cultured from human skin to study responses to the UVA radiation component of sunlight and will determine the factors and enzymatic pathways involved in the UVA regulation of this inducible anti-inflammatory response. By defining and understanding such pathways, we hope not only to advance our basic knowledge of cell biology but also to facilitate the development of more sophisticated strategies of disease prevention based on controlling the inflammatory response.
StatusFinished
Effective start/end date1/07/0630/06/09

Funding

  • BBSRC

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  • Research Output

    Development of refractoriness of ho-1 induction to a second treatment with uva radiation and the involvement of nrf2 in human skin fibroblasts

    Zhong, J. L., Raval, C. M., Nisar, M. F., Bian, C., Zhang, J., Yang, L. & Tyrrell, R. M., Nov 2014, In : Photochemistry and Photobiology. 90, 6, p. 1340-1348 9 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 5 Citations (Scopus)
    226 Downloads (Pure)

    The role of Bach1 in ultraviolet A mediated human heme oxygenase 1 regulation in human skin fibroblasts

    Raval, C. M., Zhong, J. L., Mitchell, S. A. & Tyrrell, R. M., 1 Jan 2012, In : Free Radical Biology and Medicine. 52, 1, p. 227-236 10 p.

    Research output: Contribution to journalArticle

  • 24 Citations (Scopus)

    A role for Bach1 and HO-2 in suppression of basal and UVA-induced HO-1 expression in human keratinocytes

    Zhong, J. L., Raval, C., Edwards, G. P. & Tyrrell, R. M., 15 Jan 2010, In : Free Radical Biology and Medicine. 48, 2, p. 196-206 11 p.

    Research output: Contribution to journalArticle

  • 27 Citations (Scopus)