Cutaneous squamous cell carcinoma (cSCC) accounts for the majority of deaths associated with non-melanoma skin cancers. The powerful transcriptional regulators YAP and TAZ have recently emerged as essential drivers of tumour initiation, progression and metastasis in many different cancers. YAP/TAZ are crucial for cSCC initiation, and histological evidence suggests additional roles in invasion and metastasis. This project will provide in-depth understanding of the physiological roles of YAP/TAZ during cSCC progression and will determine the molecular mechanisms underlying the oncogenic functions of YAP/TAZ to enable the development of anti YAP/TAZ therapies.
|Effective start/end date||1/10/19 → 31/10/22|
RCUK Research Areas
- Cell biology
- Biomolecules and biochemistry