New Drugs to Tackle AMR

Total Funding: £16,000

In this multidisciplinary project, we will develop novel antimicrobial compounds to treat Gram positive bacterial infections combining our expertise in drug discovery, organic synthesis, microbiology and molecular microbial ecology and evolution to enhance the ability of the agents to kill bacteria and interfere with biofilm formation. Furthermore, we will assess drug resistance and resilience with a view to deterring the rise of resistant strains. We will address the problem of diminishing efficacy of antimicrobial drugs by rationally targeting a major constituent of Gram-positive bacteria, synthesis of cell wall lipoteichoic acid.