Multi-level orthogonal characterisation of dry powder inhaler formulations for improved manufacturing process design

Dry powder inhalers are a low-carbon alternative to more commonly used pressurised inhalers. But our incomplete understanding of the links between individual particle properties, powder microstructure and aerosol performance slows their development. For the first time, this exciting project will link an understanding of nano-scale individual particle and agglomerate properties (e.g. adhesion/cohesion measured with atomic force microscopy, agglomerate strength), cutting edge developments in X-ray computer tomography that let us see inside powder microstructure and dynamic measurements aerosolisation performance (laser diffraction and impactors). This will enable rational design of manufacturing processes for faster and less expensive product development.