Genomic Epidemiology and Transmission of Campylobacter in Africa (GETcampy-Africa)

Project: UK charity

Description

Diarrhoeal disease remains a major cause of child morbidity, growth faltering and mortality in low and middle
income countries (LMICs), with Campylobacter among the most common causes. The major infection sources in
the UK include contaminated food, but transmission routes in LMICs are unknown. This means that transmission
among the children at highest risk (85% infected before 1yr in LMICs) is the least studied. House crowding,
cohabitation with animals and poor sanitation/food safety are all potential risk factors, but effective interventions
depend upon quantitative estimates of infection sources. In this program we will build on a collaborative network
across Africa to: (i) sample and genome sequence thousands of isolates from animals, food, environmental
sources and people (symptomatic, asymptomatic, and matched cases and controls); (ii) develop open-access
databases and novel analysis pipelines (association study and machine learning) to characterise Campylobacter
population structure and identify source attribution markers; (iii) investigate enteropathogen co-infection; (iv)
quantify the relative contribution of different human infection sources; (v) use a cost-benefit risk models to
identify the most effective intervention in the transmission network. This evidence-based approach will enable
effective local public health and policy interventions and focus efforts to reducing the burden of diarrhoeal
disease in Africa.
Short title2792656
StatusNot started
Effective start/end date1/06/2031/05/24