Elucidation of Final Stages in Coupling of Insulin Signalling to CLUT4 Translocation

Project: Research council

Research Output

2017

Highly potent and isoform-selective dual-site-binding tankyrase/Wnt signaling inhibitors that increase cellular glucose uptake and have anti-proliferative activity

Nathubhai, A., Haikarainen, T., Koivunen, J., Murthy, S., Koumanov, F., Lloyd, M., Holman, G., Pihlajaniemi, T., Tosh, D., Lehtio, L. & Threadgill, M., 26 Jan 2017, In : Journal of Medicinal Chemistry. 60, 2, p. 814-820 7 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
137 Downloads (Pure)

Identification of Insulin-Activated Rab Proteins in Adipose Cells Using Bio-ATB-GTP Photolabeling Technique

Koumanov, F. & Holman, G. D., 8 Dec 2017, Glucose Transport: Methods and Protocols. Lindkvist-Petersson, K. & Hansen, J. S. (eds.). New York City, USA: Humana Press, p. 137-150 14 p. (Methods in Molecular Biology; vol. 1713).

Research output: Chapter in Book/Report/Conference proceedingChapter

Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking

Zhou, Z., Menzel, F., Benninghoff, T., Chadt, A., Du, C., Holman, G. D. & Al-Hasani, H., 1 Jan 2017, In : FEBS Letters. 591, 1, p. 88-96 9 p.

Research output: Contribution to journalLetter

9 Citations (Scopus)
2015

Deletion of Both Rab-GTPase–Activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport

Chadt, A., Immisch, A., De Wendt, C., Springer, C., Zhou, Z., Stermann, T., Holman, G. D., Loffing-cueni, D., Loffing, J., Joost, H. & Al-hasani, H., Mar 2015, In : Diabetes. 64, 3, p. 746-759 14 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Insulin regulates Rab3–Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes

Koumanov, F., Pereira, V. J., Richardson, J. D., Sargent, S. L., Fazakerley, D. J. & Holman, G. D., 1 Aug 2015, In : Diabetologia. 58, 8, p. 1877-1886 10 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)
51 Downloads (Pure)

Physiological and molecular responses to an acute bout of reduced-exertion high-intensity interval training (REHIT)

Metcalfe, R. S., Koumanov, F., Ruffino, J. S., Stokes, K. A., Holman, G. D., Thompson, D. & Vollaard, N. B. J., Nov 2015, In : European Journal of Applied Physiology. 115, 11, p. 2321-2334 13 p.

Research output: Contribution to journalArticle

Open Access
File
38 Citations (Scopus)
230 Downloads (Pure)

Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumour Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes

Fazakerley, D. J., Naghiloo, S., Chaudhuri, R., Koumanov, F., Burchfield, J. G., Thomas, K. C., Krycer, J. R., Prior, M. J., Parker, B. L., Murrow, B. A., Stöckli, J., Meoli, C. C., Holman, G. D. & James, D. E., 25 Sep 2015, In : The Journal of biological chemistry. 290, 39, p. 23528-23542 15 p.

Research output: Contribution to journalArticle

Open Access
25 Citations (Scopus)
2014

The causal role of breakfast in energy balance and health: A randomized controlled trial in lean adults

Betts, J., Richardson, J. D., Chowdhury, E., Holman, G. D., Tsintzas, K. & Thompson, D., 1 Aug 2014, In : The American Journal of Clinical Nutrition. 100, 2, p. 539-547 9 p.

Research output: Contribution to journalArticle

Open Access
115 Citations (Scopus)
58 Downloads (Pure)
2013

FGT-1 is The major glucose transporter in C. elegans and is central to aging pathways

Feng, Y., Williams, BG., Koumanov, F., Wolstenholme, AJ. & Holman, G. D., 1 Dec 2013, In : Biochemical Journal. 456, 2, p. 219-229 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2012

GLUT4 Traffic through an ESCRT-III-Dependent Sorting Compartment in Adipocytes

Koumanov, F., Pereira, V. J., Whitley, P. R. & Holman, G. D., 25 Sep 2012, In : PLoS ONE. 7, 9, e44141.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2011

AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane

Koumanov, F., Richardson, J. D., Murrow, B. A. & Holman, G. D., 13 May 2011, In : Journal of Biological Chemistry. 286, 19, p. 16574-16582 9 p.

Research output: Contribution to journalArticle

File
22 Citations (Scopus)
132 Downloads (Pure)
2010

Translocation of the Na+/H+ exchanger 1 (NHE1) in cardiomyocyte responses to insulin and energy-status signalling

Lawrence, S. P., Holman, G. D. & Koumanov, F., 15 Dec 2010, In : Biochemical Journal. 432, 3, p. 515-523 9 p.

Research output: Contribution to journalArticle

File
17 Citations (Scopus)
118 Downloads (Pure)
2009

Kinetics of GLUT4 trafficking in rat and human skeletal muscle

Karlsson, H. K. R., Chibalin, A. V., Koistinen, H. A., Yang, J., Koumanov, F., Wallberg-Henriksson, H., Zierath, J. R. & Holman, G. D., Apr 2009, In : Diabetes. 58, 4, p. 847-854 8 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
2008

Regulating the motor for GLUT4 vesicle traffic

Holman, G. D. & Sakamoto, K., 2008, In : Cell Metabolism. 8, 5, p. 344-346 3 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2006
70 Citations (Scopus)