COOPERATIVE GROUP IN ORGANOGENESIS, GROWTH AND REGENERATION

2017

Highly potent and isoform-selective dual-site-binding tankyrase/Wnt signaling inhibitors that increase cellular glucose uptake and have anti-proliferative activity

Nathubhai, A., Haikarainen, T., Koivunen, J., Murthy, S., Koumanov, F., Lloyd, M., Holman, G., Pihlajaniemi, T., Tosh, D., Lehtio, L. & Threadgill, M., 26 Jan 2017, In: Journal of Medicinal Chemistry. 60, 2, p. 814-820 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

50 Citations (SciVal)

368 Downloads (Pure)

2016

The causal role of breakfast in energy balance and health: A randomized controlled trial in obese adults

Chowdhury, E., Richardson, J., Holman, G. D., Tsintzas, K., Thompson, D. & Betts, J., 1 Mar 2016, In: The American Journal of Clinical Nutrition. 103, 3, p. 747-756 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

141 Citations (SciVal)

62 Downloads (Pure)

2015

Deletion of Both Rab-GTPase–Activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport

Chadt, A., Immisch, A., De Wendt, C., Springer, C., Zhou, Z., Stermann, T., Holman, G. D., Loffing-cueni, D., Loffing, J., Joost, H.-G. & Al-hasani, H., Mar 2015, In: Diabetes. 64, 3, p. 746-759 14 p.

Research output: Contribution to journal › Article › peer-review

72 Citations (SciVal)

Insulin regulates Rab3–Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes

Koumanov, F., Pereira, V. J., Richardson, J. D., Sargent, S. L., Fazakerley, D. J. & Holman, G. D., 1 Aug 2015, In: Diabetologia. 58, 8, p. 1877-1886 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (SciVal)

51 Downloads (Pure)

Physiological and molecular responses to an acute bout of reduced-exertion high-intensity interval training (REHIT)

Metcalfe, R. S., Koumanov, F., Ruffino, J. S., Stokes, K. A., Holman, G. D., Thompson, D. & Vollaard, N. B. J., Nov 2015, In: European Journal of Applied Physiology. 115, 11, p. 2321-2334 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

79 Citations (SciVal)

396 Downloads (Pure)

Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumour Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes

Fazakerley, D. J., Naghiloo, S., Chaudhuri, R., Koumanov, F., Burchfield, J. G., Thomas, K. C., Krycer, J. R., Prior, M. J., Parker, B. L., Murrow, B. A., Stöckli, J., Meoli, C. C., Holman, G. D. & James, D. E., 25 Sept 2015, In: The Journal of biological chemistry. 290, 39, p. 23528-23542 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Citations (SciVal)

2014

Developmental Programming Mediated by Complementary Roles of Imprinted Grb10 in Mother and Pup

Cowley, M., Garfield, A. S., Madon-Simon, M., Charalambous, M., Clarkson, R. W., Smalley, M. J., Kendrick, H., Isles, A. R., Parry, A. J., Carney, S., Oakey, R. J., Heisler, L. K., Moorwood, K., Wolf, J. B. & Ward, A., 28 Feb 2014, In: PLoS Biology. 12, 2, p. 1-13 13 p., e1001799.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Citations (SciVal)

50 Downloads (Pure)

The causal role of breakfast in energy balance and health: A randomized controlled trial in lean adults

Betts, J., Richardson, J. D., Chowdhury, E., Holman, G. D., Tsintzas, K. & Thompson, D., 1 Aug 2014, In: The American Journal of Clinical Nutrition. 100, 2, p. 539-547 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

181 Citations (SciVal)

58 Downloads (Pure)

2012

A novel transgenic line using the Cre-lox system to allow permanent lineage-labeling of the zebrafish neural crest

Rodrigues, F. S. L. M., Doughton, G., Yang, B. & Kelsh, R. N., 2012, In: Genesis. 50, 10, p. 750-757

Research output: Contribution to journal › Article › peer-review

31 Citations (SciVal)

GLUT4 Traffic through an ESCRT-III-Dependent Sorting Compartment in Adipocytes

Koumanov, F., Pereira, V. J., Whitley, P. R. & Holman, G. D., 25 Sept 2012, In: PLoS ONE. 7, 9, e44141.

Research output: Contribution to journal › Article › peer-review

19 Citations (SciVal)

2011

An iterative genetic and dynamical modelling approach identifies novel features of the gene regulatory network underlying melanocyte development

Greenhill, E. R., Rocco, A., Vibert, L., Nikaido, M. & Kelsh, R. N., 1 Sept 2011, In: Plos Genetics. 7, 9, 18 p., e1002265.

Research output: Contribution to journal › Article › peer-review

59 Citations (SciVal)

Deciphering the cellular and molecular roles of cellular nucleic acid binding protein during cranial neural crest development

Weiner, A. M. J., Sdrigotti, M. A., Kelsh, R. N. & Calcaterra, N. B., 2011, In: Development Growth & Differentiation. 53, 8, p. 934-947

Research output: Contribution to journal › Article › peer-review

21 Citations (SciVal)

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

Garfield, A. S., Cowley, M., Smith, F. M., Moorwood, K., Stewart-Cox, J. E., Gilroy, K., Baker, S., Xia, J., Dalley, J. W., Hurst, L. D., Wilkinson, L. S., Isles, A. R. & Ward, A., 27 Jan 2011, In: Nature. 469, 7331, p. 534-538 5 p.

Research output: Contribution to journal › Article › peer-review

169 Citations (SciVal)

2010

Barrett's metaplasia: molecular mechanisms and nutritional influences

Slack, J. M. W., Colleypriest, B. J., Quinlan, J. M., Yu, W. Y., Farrant, J. M. & Tosh, D., Apr 2010, In: Biochemical Society Transactions. 38, 2, p. 313-319 7 p.

Research output: Contribution to journal › Article

8 Citations (SciVal)

GroEL dependency affects codon usage-support for a critical role of misfolding in gene evolution

Warnecke, T. & Hurst, L. D., 19 Jan 2010, In: Molecular Systems Biology. 6, 340.

Research output: Contribution to journal › Article › peer-review

File

52 Citations (SciVal)

194 Downloads (Pure)

Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis

Recino, A., Sherwood, V., Flaxman, A., Cooper, W., Latif, F., Ward, A. & Chalmers, A. D., 30 Sept 2010, In: Biochemical Journal. 430, 2, p. 207-213 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Citations (SciVal)

73 Downloads (Pure)

Kinetic evidence for unique regulation of GLUT4 trafficking by insulin and AMP-activated protein kinase activators in L6 myotubes

Fazakerley, D. J., Holman, G. D., Marley, A., James, D. E., Stockli, J. & Coster, A. C. F., 15 Jan 2010, In: Journal of Biological Chemistry. 285, 3, p. 1653-1660 8 p.

Research output: Contribution to journal › Article › peer-review

67 Citations (SciVal)

Maternally-inherited Grb10 reduces placental size and efficiency

Charalambous, M., Cowley, M., Geoghegan, F., Smith, F. M., Radford, E. J., Marlow, B. P., Graham, C. F., Hurst, L. D. & Ward, A., 1 Jan 2010, In: Developmental Biology. 337, 1, p. 1-8 8 p.

Research output: Contribution to journal › Article › peer-review

81 Citations (SciVal)

Streptozotocin-induced diabetes modulates action potentials and ion channel currents from the rat atrioventricular node

Yuill, K. H., Tosh, D. & Hancox, J. C., Apr 2010, In: Experimental Physiology. 95, 4, p. 508-517 10 p.

Research output: Contribution to journal › Article › peer-review

11 Citations (SciVal)

The role of Cdx2 in Barrett's metaplasia

Colleypriest, B. J., Farrant, J. M., Slack, J. M. W. & Tosh, D., Apr 2010, In: Biochemical Society Transactions. 38, 2, p. 364-369 6 p.

Research output: Contribution to journal › Article

19 Citations (SciVal)

Timing of replication is a determinant of neutral substitution rates but does not explain slow Y chromosome evolution in rodents

Pink, C. J. & Hurst, L. D., May 2010, In: Molecular Biology and Evolution. 27, 5, p. 1077-1086 10 p.

Research output: Contribution to journal › Article › peer-review

24 Citations (SciVal)

Unique cost dynamics elucidate the role of frameshifting errors in promoting translational robustness

Warnecke, T., Huang, Y., Przytycka, T. M. & Hurst, L. D., 5 Aug 2010, In: Genome biology and evolution. 2, p. 636-645 10 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (SciVal)

2009

A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling

Fazakerley, D. J., Lawrence, S. P., Lizunov, V. A., Cushman, S. W. & Holman, G. D., 1 Mar 2009, In: Journal of Cell Science. 122, 5, p. 727-734 8 p.

Research output: Contribution to journal › Article › peer-review

43 Citations (SciVal)

A zebrafish model for Waardenburg syndrome type IV reveals diverse roles for Sox10 in the otic vesicle

Dutton, K., Abbas, L., Spencer, J., Brannon, C., Mowbray, C., Nikaido, M., Kelsh, R. N. & Whitfield, T. T., Jan 2009, In: Disease Models and Mechanisms. 2, 1-2, p. 68-83 16 p.

Research output: Contribution to journal › Article › peer-review

47 Citations (SciVal)

Cdx genes, inflammation and the pathogenesis of Barrett's metaplasia

Colleypriest, B. J., Palmer, R. M., Ward, S. G. & Tosh, D., Jul 2009, In: Trends in Molecular Medicine. 15, 7, p. 313-322 10 p.

Research output: Contribution to journal › Article › peer-review

27 Citations (SciVal)

Does negative auto-regulation increase gene duplicability?

Warnecke, T., Wang, G. Z., Lercher, M. J. & Hurst, L. D., Aug 2009, In: BMC Evolutionary Biology. 9, 193.

Research output: Contribution to journal › Article › peer-review

File

3 Citations (SciVal)

150 Downloads (Pure)

Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis

Holt, L. J., Lyons, R. J., Ryan, A. S., Beale, S. M., Ward, A., Cooney, G. J. & Daly, R. J., 2009, In: Molecular Endocrinology. 23, 9, p. 1406-1414 9 p.

Research output: Contribution to journal › Article › peer-review

49 Citations (SciVal)

Evidence that replication-associated mutation alone does not explain between-chromosome differences in substitution rates

Pink, C. J., Swaminathan, S. K., Dunham, I., Rogers, J., Ward, A. & Hurst, L. D., May 2009, In: Genome biology and evolution. 2009, p. 13-22 10 p.

Research output: Contribution to journal › Article › peer-review

Evolutionary genomics and the reach of selection

Hurst, L. D., Feb 2009, In: Journal of Biology. 8, 2, p. 12 1 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (SciVal)

Frequent long-range epigenetic silencing of Protocadherin gene clusters on chromosome 5q31 in Wilms' Tumor

Dallosso, A. R., Hancock, A. L., Szemes, M., Moorwood, K., Chilukamarri, L., Tsai, H. H., Sarkar, A., Barasch, J., Vuononvirta, R., Jones, C., Pritchard-Jones, K., Royer-Pokora, B., Lee, S. B., Owen, C., Malik, S., Feng, Y., Frank, M., Ward, A., Brown, K. W. & Malik, K., 26 Nov 2009, In: Plos Genetics. 5, 11, 13 p., e1000745.

Research output: Contribution to journal › Article › peer-review

File

126 Citations (SciVal)

196 Downloads (Pure)

Fundamental concepts in genetics: Genetics and the understanding of selection

Hurst, L. D., 2009, In: Nature Reviews Genetics. 10, 2, p. 83-93 11 p.

Research output: Contribution to journal › Article › peer-review

100 Citations (SciVal)

How does inflammation cause Barrett's metaplasia?

Colleypriest, B. J., Ward, S. G. & Tosh, D., Dec 2009, In: Current Opinion in Pharmacology. 9, 6, p. 721-726 6 p.

Research output: Contribution to journal › Article › peer-review

43 Citations (SciVal)

Inhibition of Hes1 activity in gall bladder epithelial cells promotes insulin expression and glucose responsiveness

Coad, R. A., Dutton, J. R., Tosh, D. & Slack, J., 2009, In: Biochemistry and Cell Biology - Biochimie Et Biologie Cellulaire. 87, 6, p. 975-987 13 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (SciVal)

Liver zonation occurs through a β-catenin–dependent, c-Myc–independent mechanism

Burke, Z. D., Reed, K. R., Phesse, T. J., Sansom, O. J., Clarke, A. R. & Tosh, D., Jun 2009, In: Gastroenterology. 136, 7, p. 2316-2324e3 9 p.

Research output: Contribution to journal › Article › peer-review

135 Citations (SciVal)

Metaplasia and somatic cell reprogramming

Slack, J., 2009, In: The Journal of Pathology. 217, 2, p. 161-168 8 p.

Research output: Contribution to journal › Article › peer-review

28 Citations (SciVal)

Protein rates of evolution are predicted by double-strand break events, independent of crossing-over rates

Weber, C. C. & Hurst, L. D., Sept 2009, In: Genome biology and evolution. 2009, p. 340-349 10 p.

Research output: Contribution to journal › Article › peer-review

Stripes and belly-spots: a review of pigment cell morphogenesis in vertebrates

Kelsh, R. N., Harris, M. L., Colanesi, S. & Erickson, C. A., 2009, In: Seminars in Cell & Developmental Biology. 20, 1, p. 90-104

Research output: Contribution to journal › Article › peer-review

159 Citations (SciVal)

The price of silent mutations: Small changes to DNA that were once considered innocuous enough to be ignored are proving to be important in human diseases, evolution and biotechnology

Chamary, J. V. & Hurst, L. D., 30 Jun 2009, In: Scientific American. 300, 6, p. 46-53 8 p.

Research output: Contribution to journal › Article › peer-review

64 Citations (SciVal)

Why there is more to protein evolution than protein function: Splicing, nucleosomes and dual-coding sequence

Warnecke, T., Weber, C. C. & Hurst, L. D., 2009, In: Biochemical Society Transactions. 37, 4, p. 756-761 6 p.

Research output: Contribution to journal › Article › peer-review

32 Citations (SciVal)

2008

Determination of pelvic ring stability: a new technique using a composite hemi-pelvis

Clements, J. P., Moriaty, N., Chesser, T. S., Ward, A. J. & Cunningham, J. L., 1 May 2008, In: Proceedings of the Institution of Mechanical Engineers, Part H - Journal of Engineering in Medicine. 222, 5, p. 611-616 6 p.

Research output: Contribution to journal › Article › peer-review

11 Citations (SciVal)

Do Alu repeats drive the evolution of the primate transcriptome?

Urrutia, A. O., Ocana, L. B. & Hurst, L. D., 1 Feb 2008, In: Genome Biology. 9, 2, 16 p., R25.

Research output: Contribution to journal › Article › peer-review

File

18 Citations (SciVal)

137 Downloads (Pure)

Finding exonic islands in a sea of non-coding sequence: splicing related constraints on protein composition and evolution are common in intron-rich genomes

Warnecke, T., Parmley, J. L. & Hurst, L. D., 7 Feb 2008, In: Genome Biology. 9, 2, R29.

Research output: Contribution to journal › Article › peer-review

File

33 Citations (SciVal)

173 Downloads (Pure)

Leukocyte tyrosine kinase functions in pigment cell development

Lopes, S. S., Yang, X. Y., Muller, J., Carney, T. J., McAdow, A. R., Rauch, G.-J., Jacoby, A. S., Hurst, L. D., Delfino-Machin, M., Haffter, P., Geisler, R., Johnson, S. L., Ward, A. & Kelsh, R. N., 7 Mar 2008, In: Plos Genetics. 4, 3, 13 p., e1000026.

Research output: Contribution to journal › Article › peer-review

Open Access

File