Research output per year
Research output per year
- 1 - 50 out of 104 results
Search results
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2017
Highly potent and isoform-selective dual-site-binding tankyrase/Wnt signaling inhibitors that increase cellular glucose uptake and have anti-proliferative activity
Nathubhai, A., Haikarainen, T., Koivunen, J., Murthy, S., Koumanov, F., Lloyd, M., Holman, G., Pihlajaniemi, T., Tosh, D., Lehtio, L. & Threadgill, M., 26 Jan 2017, In: Journal of Medicinal Chemistry. 60, 2, p. 814-820 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile55 Link opens in a new tab Citations (SciVal)523 Downloads (Pure) -
2016
The causal role of breakfast in energy balance and health: A randomized controlled trial in obese adults
Chowdhury, E., Richardson, J., Holman, G. D., Tsintzas, K., Thompson, D. & Betts, J., 1 Mar 2016, In: The American Journal of Clinical Nutrition. 103, 3, p. 747-756 10 p.Research output: Contribution to journal › Article › peer-review
Open Access156 Link opens in a new tab Citations (SciVal)62 Downloads (Pure) -
2015
Deletion of Both Rab-GTPase–Activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport
Chadt, A., Immisch, A., De Wendt, C., Springer, C., Zhou, Z., Stermann, T., Holman, G. D., Loffing-cueni, D., Loffing, J., Joost, H.-G. & Al-hasani, H., Mar 2015, In: Diabetes. 64, 3, p. 746-759 14 p.Research output: Contribution to journal › Article › peer-review
74 Link opens in a new tab Citations (SciVal) -
Insulin regulates Rab3–Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes
Koumanov, F., Pereira, V. J., Richardson, J. D., Sargent, S. L., Fazakerley, D. J. & Holman, G. D., 1 Aug 2015, In: Diabetologia. 58, 8, p. 1877-1886 10 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Link opens in a new tab Citations (SciVal)51 Downloads (Pure) -
Physiological and molecular responses to an acute bout of reduced-exertion high-intensity interval training (REHIT)
Metcalfe, R. S., Koumanov, F., Ruffino, J. S., Stokes, K. A., Holman, G. D., Thompson, D. & Vollaard, N. B. J., Nov 2015, In: European Journal of Applied Physiology. 115, 11, p. 2321-2334 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile86 Link opens in a new tab Citations (SciVal)565 Downloads (Pure) -
Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumour Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes
Fazakerley, D. J., Naghiloo, S., Chaudhuri, R., Koumanov, F., Burchfield, J. G., Thomas, K. C., Krycer, J. R., Prior, M. J., Parker, B. L., Murrow, B. A., Stöckli, J., Meoli, C. C., Holman, G. D. & James, D. E., 25 Sept 2015, In: The Journal of biological chemistry. 290, 39, p. 23528-23542 15 p.Research output: Contribution to journal › Article › peer-review
Open Access54 Link opens in a new tab Citations (SciVal) -
2014
Developmental Programming Mediated by Complementary Roles of Imprinted Grb10 in Mother and Pup
Cowley, M., Garfield, A. S., Madon-Simon, M., Charalambous, M., Clarkson, R. W., Smalley, M. J., Kendrick, H., Isles, A. R., Parry, A. J., Carney, S., Oakey, R. J., Heisler, L. K., Moorwood, K., Wolf, J. B. & Ward, A., 28 Feb 2014, In: PLoS Biology. 12, 2, p. 1-13 13 p., e1001799.Research output: Contribution to journal › Article › peer-review
Open Access49 Link opens in a new tab Citations (SciVal)50 Downloads (Pure) -
The causal role of breakfast in energy balance and health: A randomized controlled trial in lean adults
Betts, J., Richardson, J. D., Chowdhury, E., Holman, G. D., Tsintzas, K. & Thompson, D., 1 Aug 2014, In: The American Journal of Clinical Nutrition. 100, 2, p. 539-547 9 p.Research output: Contribution to journal › Article › peer-review
Open Access199 Link opens in a new tab Citations (SciVal)58 Downloads (Pure) -
2012
A novel transgenic line using the Cre-lox system to allow permanent lineage-labeling of the zebrafish neural crest
Rodrigues, F. S. L. M., Doughton, G., Yang, B. & Kelsh, R. N., 2012, In: Genesis. 50, 10, p. 750-757Research output: Contribution to journal › Article › peer-review
32 Link opens in a new tab Citations (SciVal) -
GLUT4 Traffic through an ESCRT-III-Dependent Sorting Compartment in Adipocytes
Koumanov, F., Pereira, V. J., Whitley, P. R. & Holman, G. D., 25 Sept 2012, In: PLoS ONE. 7, 9, e44141.Research output: Contribution to journal › Article › peer-review
20 Link opens in a new tab Citations (SciVal) -
2011
An iterative genetic and dynamical modelling approach identifies novel features of the gene regulatory network underlying melanocyte development
Greenhill, E. R., Rocco, A., Vibert, L., Nikaido, M. & Kelsh, R. N., 1 Sept 2011, In: Plos Genetics. 7, 9, 18 p., e1002265.Research output: Contribution to journal › Article › peer-review
65 Link opens in a new tab Citations (SciVal) -
Deciphering the cellular and molecular roles of cellular nucleic acid binding protein during cranial neural crest development
Weiner, A. M. J., Sdrigotti, M. A., Kelsh, R. N. & Calcaterra, N. B., 2011, In: Development Growth & Differentiation. 53, 8, p. 934-947Research output: Contribution to journal › Article › peer-review
21 Link opens in a new tab Citations (SciVal) -
Distinct physiological and behavioural functions for parental alleles of imprinted Grb10
Garfield, A. S., Cowley, M., Smith, F. M., Moorwood, K., Stewart-Cox, J. E., Gilroy, K., Baker, S., Xia, J., Dalley, J. W., Hurst, L. D., Wilkinson, L. S., Isles, A. R. & Ward, A., 27 Jan 2011, In: Nature. 469, 7331, p. 534-538 5 p.Research output: Contribution to journal › Article › peer-review
184 Link opens in a new tab Citations (SciVal) -
2010
Barrett's metaplasia: molecular mechanisms and nutritional influences
Slack, J. M. W., Colleypriest, B. J., Quinlan, J. M., Yu, W. Y., Farrant, J. M. & Tosh, D., Apr 2010, In: Biochemical Society Transactions. 38, 2, p. 313-319 7 p.Research output: Contribution to journal › Article
8 Link opens in a new tab Citations (SciVal) -
GroEL dependency affects codon usage-support for a critical role of misfolding in gene evolution
Warnecke, T. & Hurst, L. D., 19 Jan 2010, In: Molecular Systems Biology. 6, 340.Research output: Contribution to journal › Article › peer-review
File53 Link opens in a new tab Citations (SciVal)260 Downloads (Pure) -
Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis
Recino, A., Sherwood, V., Flaxman, A., Cooper, W., Latif, F., Ward, A. & Chalmers, A. D., 30 Sept 2010, In: Biochemical Journal. 430, 2, p. 207-213 7 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Link opens in a new tab Citations (SciVal)73 Downloads (Pure) -
Kinetic evidence for unique regulation of GLUT4 trafficking by insulin and AMP-activated protein kinase activators in L6 myotubes
Fazakerley, D. J., Holman, G. D., Marley, A., James, D. E., Stockli, J. & Coster, A. C. F., 15 Jan 2010, In: Journal of Biological Chemistry. 285, 3, p. 1653-1660 8 p.Research output: Contribution to journal › Article › peer-review
70 Link opens in a new tab Citations (SciVal) -
Maternally-inherited Grb10 reduces placental size and efficiency
Charalambous, M., Cowley, M., Geoghegan, F., Smith, F. M., Radford, E. J., Marlow, B. P., Graham, C. F., Hurst, L. D. & Ward, A., 1 Jan 2010, In: Developmental Biology. 337, 1, p. 1-8 8 p.Research output: Contribution to journal › Article › peer-review
86 Link opens in a new tab Citations (SciVal) -
Streptozotocin-induced diabetes modulates action potentials and ion channel currents from the rat atrioventricular node
Yuill, K. H., Tosh, D. & Hancox, J. C., Apr 2010, In: Experimental Physiology. 95, 4, p. 508-517 10 p.Research output: Contribution to journal › Article › peer-review
11 Link opens in a new tab Citations (SciVal) -
The role of Cdx2 in Barrett's metaplasia
Colleypriest, B. J., Farrant, J. M., Slack, J. M. W. & Tosh, D., Apr 2010, In: Biochemical Society Transactions. 38, 2, p. 364-369 6 p.Research output: Contribution to journal › Article
20 Link opens in a new tab Citations (SciVal) -
Timing of replication is a determinant of neutral substitution rates but does not explain slow Y chromosome evolution in rodents
Pink, C. J. & Hurst, L. D., May 2010, In: Molecular Biology and Evolution. 27, 5, p. 1077-1086 10 p.Research output: Contribution to journal › Article › peer-review
25 Link opens in a new tab Citations (SciVal) -
Unique cost dynamics elucidate the role of frameshifting errors in promoting translational robustness
Warnecke, T., Huang, Y., Przytycka, T. M. & Hurst, L. D., 5 Aug 2010, In: Genome biology and evolution. 2, p. 636-645 10 p.Research output: Contribution to journal › Article › peer-review
10 Link opens in a new tab Citations (SciVal) -
2009
A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling
Fazakerley, D. J., Lawrence, S. P., Lizunov, V. A., Cushman, S. W. & Holman, G. D., 1 Mar 2009, In: Journal of Cell Science. 122, 5, p. 727-734 8 p.Research output: Contribution to journal › Article › peer-review
46 Link opens in a new tab Citations (SciVal) -
A zebrafish model for Waardenburg syndrome type IV reveals diverse roles for Sox10 in the otic vesicle
Dutton, K., Abbas, L., Spencer, J., Brannon, C., Mowbray, C., Nikaido, M., Kelsh, R. N. & Whitfield, T. T., Jan 2009, In: Disease Models and Mechanisms. 2, 1-2, p. 68-83 16 p.Research output: Contribution to journal › Article › peer-review
52 Link opens in a new tab Citations (SciVal) -
Cdx genes, inflammation and the pathogenesis of Barrett's metaplasia
Colleypriest, B. J., Palmer, R. M., Ward, S. G. & Tosh, D., Jul 2009, In: Trends in Molecular Medicine. 15, 7, p. 313-322 10 p.Research output: Contribution to journal › Article › peer-review
29 Link opens in a new tab Citations (SciVal) -
Does negative auto-regulation increase gene duplicability?
Warnecke, T., Wang, G. Z., Lercher, M. J. & Hurst, L. D., Aug 2009, In: BMC Evolutionary Biology. 9, 193.Research output: Contribution to journal › Article › peer-review
File3 Link opens in a new tab Citations (SciVal)187 Downloads (Pure) -
Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis
Holt, L. J., Lyons, R. J., Ryan, A. S., Beale, S. M., Ward, A., Cooney, G. J. & Daly, R. J., 2009, In: Molecular Endocrinology. 23, 9, p. 1406-1414 9 p.Research output: Contribution to journal › Article › peer-review
52 Link opens in a new tab Citations (SciVal) -
Evidence that replication-associated mutation alone does not explain between-chromosome differences in substitution rates
Pink, C. J., Swaminathan, S. K., Dunham, I., Rogers, J., Ward, A. & Hurst, L. D., May 2009, In: Genome biology and evolution. 2009, p. 13-22 10 p.Research output: Contribution to journal › Article › peer-review
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Evolutionary genomics and the reach of selection
Hurst, L. D., Feb 2009, In: Journal of Biology. 8, 2, p. 12 1 p.Research output: Contribution to journal › Article › peer-review
19 Link opens in a new tab Citations (SciVal) -
Frequent long-range epigenetic silencing of Protocadherin gene clusters on chromosome 5q31 in Wilms' Tumor
Dallosso, A. R., Hancock, A. L., Szemes, M., Moorwood, K., Chilukamarri, L., Tsai, H. H., Sarkar, A., Barasch, J., Vuononvirta, R., Jones, C., Pritchard-Jones, K., Royer-Pokora, B., Lee, S. B., Owen, C., Malik, S., Feng, Y., Frank, M., Ward, A., Brown, K. W. & Malik, K., 26 Nov 2009, In: Plos Genetics. 5, 11, 13 p., e1000745.Research output: Contribution to journal › Article › peer-review
File135 Link opens in a new tab Citations (SciVal)261 Downloads (Pure) -
Fundamental concepts in genetics: Genetics and the understanding of selection
Hurst, L. D., 2009, In: Nature Reviews Genetics. 10, 2, p. 83-93 11 p.Research output: Contribution to journal › Article › peer-review
107 Link opens in a new tab Citations (SciVal) -
How does inflammation cause Barrett's metaplasia?
Colleypriest, B. J., Ward, S. G. & Tosh, D., Dec 2009, In: Current Opinion in Pharmacology. 9, 6, p. 721-726 6 p.Research output: Contribution to journal › Article › peer-review
45 Link opens in a new tab Citations (SciVal) -
Inhibition of Hes1 activity in gall bladder epithelial cells promotes insulin expression and glucose responsiveness
Coad, R. A., Dutton, J. R., Tosh, D. & Slack, J., 2009, In: Biochemistry and Cell Biology - Biochimie Et Biologie Cellulaire. 87, 6, p. 975-987 13 p.Research output: Contribution to journal › Article › peer-review
18 Link opens in a new tab Citations (SciVal) -
Liver zonation occurs through a β-catenin–dependent, c-Myc–independent mechanism
Burke, Z. D., Reed, K. R., Phesse, T. J., Sansom, O. J., Clarke, A. R. & Tosh, D., Jun 2009, In: Gastroenterology. 136, 7, p. 2316-2324e3 9 p.Research output: Contribution to journal › Article › peer-review
148 Link opens in a new tab Citations (SciVal) -
Metaplasia and somatic cell reprogramming
Slack, J., 2009, In: The Journal of Pathology. 217, 2, p. 161-168 8 p.Research output: Contribution to journal › Article › peer-review
28 Link opens in a new tab Citations (SciVal) -
Protein rates of evolution are predicted by double-strand break events, independent of crossing-over rates
Weber, C. C. & Hurst, L. D., Sept 2009, In: Genome biology and evolution. 2009, p. 340-349 10 p.Research output: Contribution to journal › Article › peer-review
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Stripes and belly-spots: a review of pigment cell morphogenesis in vertebrates
Kelsh, R. N., Harris, M. L., Colanesi, S. & Erickson, C. A., 2009, In: Seminars in Cell & Developmental Biology. 20, 1, p. 90-104Research output: Contribution to journal › Article › peer-review
180 Link opens in a new tab Citations (SciVal) -
The price of silent mutations: Small changes to DNA that were once considered innocuous enough to be ignored are proving to be important in human diseases, evolution and biotechnology
Chamary, J. V. & Hurst, L. D., 30 Jun 2009, In: Scientific American. 300, 6, p. 46-53 8 p.Research output: Contribution to journal › Article › peer-review
67 Link opens in a new tab Citations (SciVal) -
Why there is more to protein evolution than protein function: Splicing, nucleosomes and dual-coding sequence
Warnecke, T., Weber, C. C. & Hurst, L. D., 2009, In: Biochemical Society Transactions. 37, 4, p. 756-761 6 p.Research output: Contribution to journal › Article › peer-review
35 Link opens in a new tab Citations (SciVal) -
2008
Determination of pelvic ring stability: a new technique using a composite hemi-pelvis
Clements, J. P., Moriaty, N., Chesser, T. S., Ward, A. J. & Cunningham, J. L., 1 May 2008, In: Proceedings of the Institution of Mechanical Engineers, Part H - Journal of Engineering in Medicine. 222, 5, p. 611-616 6 p.Research output: Contribution to journal › Article › peer-review
11 Link opens in a new tab Citations (SciVal) -
Do Alu repeats drive the evolution of the primate transcriptome?
Urrutia, A. O., Ocana, L. B. & Hurst, L. D., 1 Feb 2008, In: Genome Biology. 9, 2, 16 p., R25.Research output: Contribution to journal › Article › peer-review
File19 Link opens in a new tab Citations (SciVal)173 Downloads (Pure) -
Finding exonic islands in a sea of non-coding sequence: splicing related constraints on protein composition and evolution are common in intron-rich genomes
Warnecke, T., Parmley, J. L. & Hurst, L. D., 7 Feb 2008, In: Genome Biology. 9, 2, R29.Research output: Contribution to journal › Article › peer-review
File33 Link opens in a new tab Citations (SciVal)217 Downloads (Pure) -
Leukocyte tyrosine kinase functions in pigment cell development
Lopes, S. S., Yang, X. Y., Muller, J., Carney, T. J., McAdow, A. R., Rauch, G.-J., Jacoby, A. S., Hurst, L. D., Delfino-Machin, M., Haffter, P., Geisler, R., Johnson, S. L., Ward, A. & Kelsh, R. N., 7 Mar 2008, In: Plos Genetics. 4, 3, 13 p., e1000026.Research output: Contribution to journal › Article › peer-review
Open AccessFile126 Link opens in a new tab Citations (SciVal)256 Downloads (Pure) -
Origin of beta-cells in regenerating pancreas
O'Neill, K. E., Eberhard, D. & Tosh, D., 2008, In: Bioessays. 30, 7, p. 617-620 4 p.Research output: Contribution to journal › Article › peer-review
6 Link opens in a new tab Citations (SciVal) -
Origin of pancreatic endocrine cells from biliary duct epithelium
Eberhard, D., Tosh, D. & Slack, J., 2008, In: Cellular and Molecular Life Sciences (CMLS). 65, 21, p. 3467-3480 14 p.Research output: Contribution to journal › Article › peer-review
33 Link opens in a new tab Citations (SciVal) -
Origin of stem cells in organogenesis
Slack, J., 5 Dec 2008, In: Science. 332, 5907, p. 1498-1501 4 p.Research output: Contribution to journal › Article › peer-review
158 Link opens in a new tab Citations (SciVal) -
Regulating the motor for GLUT4 vesicle traffic
Holman, G. D. & Sakamoto, K., 2008, In: Cell Metabolism. 8, 5, p. 344-346 3 p.Research output: Contribution to journal › Article › peer-review
9 Link opens in a new tab Citations (SciVal) -
Requirement for Wnt and FGF signaling in Xenopus tadpole tail regeneration
Lin, G. & Slack, J., 2008, In: Developmental Biology. 316, 2, p. 323-335 13 p.Research output: Contribution to journal › Article › peer-review
144 Link opens in a new tab Citations (SciVal) -
The Impact of the Nucleosome Code on Protein-Coding Sequence Evolution in Yeast
Warnecke, T., Batada, N. N. & Hurst, L. D., 2008, In: Plos Genetics. 4, 11, p. e1000250Research output: Contribution to journal › Article › peer-review
File75 Link opens in a new tab Citations (SciVal)281 Downloads (Pure) -
The origin and evolution of the neural crest
Donoghue, P. C. J., Graham, A. & Kelsh, R. N., 2008, In: Bioessays. 30, 6, p. 530-541Research output: Contribution to journal › Article › peer-review
129 Link opens in a new tab Citations (SciVal)