AMACR Targeted Drugs for Treating Advance Prostate Cancer

Project: UK charity

Project Details

StatusFinished
Effective start/end date1/02/1530/07/18

Funding

  • Prostate Cancer UK

Research Output

Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents

Jevglevskis, M., Nathubhai, A., Wadda, K., Lee, G. L., Al-Rawi, S., Jiao, T., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103263.

Research output: Contribution to journalArticle

Open Access
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66 Downloads (Pure)

Structure-activity relationships of rationally designed AMACR 1A inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Sep 2018, In : Bioorganic and Medicinal Chemistry. 79, p. 145-154 10 p.

Research output: Contribution to journalArticle

Open Access
File
  • 2 Citations (Scopus)
    29 Downloads (Pure)

    A novel colorimetric assay for α-methylacyl-CoA racemase 1A (AMACR; P504S) utilizing the elimination of 2,4-dinitrophenolate

    Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 7 May 2017, In : Chemical Communications. 53, 37, p. 5087-5090 4 p.

    Research output: Contribution to journalArticle

    Open Access
  • 6 Citations (Scopus)