• 4 SOUTH 1.03

20002018
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Personal profile

Research interests

Our research focuses on molecular characterisation of compatible and incompatible interactions between plants and their pathogens. Our research interests include mechanistic understanding of processes such as how plant immune receptors perceive microbial pathogenicity proteins (effectors) in order to activate defence and how pathogens evolve to circumvent such recognition events. We are similarly interested in comparative genomics and evolution of pathogens with the aim of better understanding host specialization and virulence.

In order to achieve this, we work on Albugo candida – Brassicaceae pathosystem. The obligate biotrophic parasite Albugo candida infects many distinct Brassicaceae and it causes white blister rust disease resulting in significant losses on economically important oilseed and vegetable brassica crops. Albugo candida consists of physiological races that each specialize on distinct hosts. Some Albugo candida races can also infect the model plant Arabidopsis thaliana and this provides an excellent opportunity to elucidate some of the fundamental questions in plant-microbe interactions.

Our current research activities include:

  • How various White Rust Resistance (WRR) proteins recognise different races of Albugo candida and activate downstream signalling leading to resistance
  • Resistance protein engineering for a broader recognition specificity
  • Identification and characterisation of plant developmental processes manipulated by plant pathogens to impose susceptibility
  • Identification of novel susceptibility factors required for host colonisation by Albugo candida
  • How different Albugo candida races evolved to colonize distinct host species  

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Arabidopsis Medicine & Life Sciences
Pathogens Chemical Compounds
Albugo candida Agriculture & Biology
Arabidopsis thaliana Agriculture & Biology
Nucleotides Medicine & Life Sciences
pathogens Agriculture & Biology
Leucine Medicine & Life Sciences
genes Agriculture & Biology

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Research Output 2000 2018

1 Citations

Albugo candida race diversity, ploidy and host-associated microbes revealed using DNA sequence capture on diseased plants in the field

Jouet, A., Saunders, D. G. O., McMullan, M., Ward, B., Furzer, O., Jupe, F., Cevik, V., Hein, I., Thilliez, G. J. A., Holub, E., van Oosterhout, C. & Jones, J. D. G., 5 Oct 2018, In : New Phytologist.

Research output: Contribution to journalArticle

Open Access
Albugo candida
Plant Diseases
Ploidies
ploidy
Candida
1 Citations

A suppressor/avirulence gene combination in hyaloperonospora arabidopsidis determines race specificity in Arabidopsis thaliana

Woods-Tör, A., Studholme, D. J., Cevik, V., Telli, O., Holub, E. B. & Tör, M., 1 Mar 2018, In : Frontiers in Plant Science. 9, 265.

Research output: Contribution to journalArticle

Open Access
suppressor genes
Arabidopsis thaliana
alleles
signal peptide
genes

Distinct modes of derepression of an Arabidopsis immune receptor complex by two different bacterial effectors

Ma, Y., Guo, H., Hu, L., Martinez, P. P., Moschou, P. N., Cevik, V., Ding, P., Duxbury, Z., Sarris, P. F. & Jones, J. D. G., 9 Oct 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 41, p. 10218-10227 10 p.

Research output: Contribution to journalArticle

Open Access
Antigen-Antibody Complex
Leucine
Nucleotides
Colicins
Arabidopsis
1 Citations

Albugo-imposed changes to tryptophan-derived antimicrobial metabolite biosynthesis may contribute to suppression of non-host resistance to Phytophthora infestans in Arabidopsis thaliana

Prince, D. C., Rallapalli, G., Xu, D., Schoonbeek, H. J., Çevik, V., Asai, S., Kemen, E., Cruz-Mireles, N., Kemen, A., Belhaj, K., Schornack, S., Kamoun, S., Holub, E. B., Halkier, B. A. & Jones, J. D. G., 20 Mar 2017, In : BMC Biology. 15, 1, 20.

Research output: Contribution to journalArticle

Open Access
Albugo
Phytophthora infestans
Biosynthesis
Pathogens
Metabolites
11 Citations

Protein-protein interactions in the RPS4/RRS1 immune receptor complex

Huh, S. U., Cevik, V., Ding, P., Duxbury, Z., Ma, Y., Tomlinson, L., Sarris, P. F. & Jones, J. D. G., 5 May 2017, In : PLoS Pathogens. 13, 5, p. e1006376

Research output: Contribution to journalArticle

Open Access
Antigen-Antibody Complex
Arabidopsis
vpr Genes
Proteins
Leucine