Projects per year
Personal profile
Research interests
Our research focuses on molecular characterisation of compatible and incompatible interactions between plants and their pathogens. Our research interests include mechanistic understanding of processes such as how plant immune receptors perceive microbial pathogenicity proteins (effectors) in order to activate defence and how pathogens evolve to circumvent such recognition events. We are similarly interested in comparative genomics and evolution of pathogens with the aim of better understanding host specialization and virulence.
In order to achieve this, we work on Albugo candida – Brassicaceae pathosystem. The obligate biotrophic parasite Albugo candida infects many distinct Brassicaceae and it causes white blister rust disease resulting in significant losses on economically important oilseed and vegetable brassica crops. Albugo candida consists of physiological races that each specialize on distinct hosts. Some Albugo candida races can also infect the model plant Arabidopsis thaliana and this provides an excellent opportunity to elucidate some of the fundamental questions in plant-microbe interactions.
Our current research activities include:
- How various White Rust Resistance (WRR) proteins recognise different races of Albugo candida and activate downstream signalling leading to resistance
- Resistance protein engineering for a broader recognition specificity
- Identification and characterisation of plant developmental processes manipulated by plant pathogens to impose susceptibility
- Identification of novel susceptibility factors required for host colonisation by Albugo candida
- How different Albugo candida races evolved to colonize distinct host species
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Investigating the role of CHR4 in WRR7-mediated Arabidopsis immunity to a White Blister Rust Pathogen
2/08/21 → 10/09/21
Project: Other
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Elucidating the immune signalling mediated by a novel white rust resistance protein
1/10/19 → 31/03/20
Project: Other
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An Improved Assembly of the Albugo candida Ac2V Genome Reveals the Expansion of the "CCG" Class of Effectors
Furzer, O. J., Cevik, V., Fairhead, S., Bailey, K., Redkar, A., Schudoma, C., MacLean, D., Holub, E. B. & Jones, J. D. G., 1 Jan 2022, In: Molecular plant-microbe interactions : MPMI. 35, 1, p. 39-48 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Show me your ID: NLR immune receptors with integrated domains in plants
Marchal, C., Michalopoulou, V. A., Zou, Z., Cevik, V. & Sarris, P. F., 30 May 2022, In: Essays in Biochemistry.Research output: Contribution to journal › Review article › peer-review
Open Access -
CRISPR/Cas9 System, an Efficient Approach to Genome Editing of Plants for Crop Improvement
Khabbazi, S. D., Khabbazi, A. D., Cevik, V. & Ergül, A., 12 Apr 2021, RNA-Based Technologies for Functional Genomics in Plants. Springer, p. 369-391 Chapter 16. (RNA-Based Technologies for Functional Genomics in Plants).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Evolutionary trade-offs at the Arabidopsis WRR4A resistance locus underpin alternate Albugo candida race recognition specificities
Castel, B., Fairhead, S., Furzer, O. J., Redkar, A., Wang, S., Cevik, V., Holub, E. B. & Jones, J. D. G., 30 Sep 2021, In: Plant Journal. 107, 5, p. 1490-1502 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Genetic engineering of horticultural crops contributes to the improvement of crop nutritional quality and shelf life
Khabbazi, S. D., Khabbazi, A. D., Cevik, V. & Ergül, A., 2020, Transgenic Technology Based Value Addition in Plant Biotechnology. Elsevier Masson, p. 247-272Research output: Chapter in Book/Report/Conference proceeding › Chapter