Projects per year
Our research focuses on molecular characterisation of compatible and incompatible interactions between plants and their pathogens. Our research interests include mechanistic understanding of processes such as how plant immune receptors perceive microbial pathogenicity proteins (effectors) in order to activate defence and how pathogens evolve to circumvent such recognition events. We are similarly interested in comparative genomics and evolution of pathogens with the aim of better understanding host specialization and virulence.
In order to achieve this, we work on Albugo candida – Brassicaceae pathosystem. The obligate biotrophic parasite Albugo candida infects many distinct Brassicaceae and it causes white blister rust disease resulting in significant losses on economically important oilseed and vegetable brassica crops. Albugo candida consists of physiological races that each specialize on distinct hosts. Some Albugo candida races can also infect the model plant Arabidopsis thaliana and this provides an excellent opportunity to elucidate some of the fundamental questions in plant-microbe interactions.
Our current research activities include:
- How various White Rust Resistance (WRR) proteins recognise different races of Albugo candida and activate downstream signalling leading to resistance
- Resistance protein engineering for a broader recognition specificity
- Identification and characterisation of plant developmental processes manipulated by plant pathogens to impose susceptibility
- Identification of novel susceptibility factors required for host colonisation by Albugo candida
- How different Albugo candida races evolved to colonize distinct host species
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Sero, J., Cevik, V., Gurevich, D., Jungwirth, U., Kelsh, R., Koumanov, F., Kyprianou, A., Laabei, M., Licchesi, J., Murrell, A., Pascu, S., Turner, L., Walko, G., Ward, A., Ward, S., Williams, R. & Zachariadis, M.
1/08/22 → 31/07/23
Project: Research council
Investigating the role of CHR4 in WRR7-mediated Arabidopsis immunity to a White Blister Rust Pathogen
2/08/21 → 10/09/21
1/10/19 → 31/03/20
Cell-specific RNA profiling reveals host genes expressed in Arabidopsis cells haustoriated by downy mildewAsai, S., Cevik, V., Jones, J. D. G. & Shirasu, K., 12 Jun 2023, In: Plant Physiology. 12 p., kiad326.
Research output: Contribution to journal › Article › peer-reviewOpen Access
The Arabidopsis WRR4A and WRR4B paralogous NLR proteins both confer recognition of multiple Albugo candida effectorsRedkar, A., Cevik, V., Bailey, K., Zhao, H., Kim, D. S., Zou, Z., Furzer, O. J., Fairhead, S., Borhan, M. H., Holub, E. B. & Jones, J. D. G., 31 Jan 2023, In: New Phytologist. 237, 2, p. 532-547 16 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access3 Citations (SciVal)
The integrated LIM-peptidase domain of the CSA1-CHS3/DAR4 paired immune receptor detects changes in DA1 peptidase inhibitors in ArabidopsisGu, B., Parkes, T., Rabanal, F., Smith, C., Lu, F. H., McKenzie, N., Dong, H., Weigel, D., Jones, J. D. G., Cevik, V. & Bevan, M. W., 14 Jun 2023, In: Cell Host and Microbe. 31, 6, p. 949-961.e5
Research output: Contribution to journal › Article › peer-reviewOpen Access1 Citation (SciVal)
Allelic variation in the Arabidopsis TNL CHS3/CSA1 immune receptor pair reveals two functional cell-death regulatory modesYang, Y., Kim, N. H., Cevik, V., Jacob, P., Wan, L., Furzer, O. J. & Dangl, J. L., 14 Dec 2022, In: Cell Host and Microbe. 30, 12, p. 1701-1716.e5
Research output: Contribution to journal › Article › peer-reviewOpen Access10 Citations (SciVal)
An Improved Assembly of the Albugo candida Ac2V Genome Reveals the Expansion of the "CCG" Class of EffectorsFurzer, O. J., Cevik, V., Fairhead, S., Bailey, K., Redkar, A., Schudoma, C., MacLean, D., Holub, E. B. & Jones, J. D. G., 1 Jan 2022, In: Molecular plant-microbe interactions : MPMI. 35, 1, p. 39-48 10 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access4 Citations (SciVal)