• 4 SOUTH 0.67

Accepting Doctoral Students

1989 …2020

Research output per year

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Personal profile

Research interests

Memberships of Professional Bodies

Biochemical Society, BSDB, Genetics Society, Anatomical Society, Indian Society of Cell Biology (Life member)

Current Funding

 

  • Motor Neurone Disease Association - Mouse models for ALS

 

Collaborations

We are involved in a number of collaborative studies both within UK and abroad:

  • Structure function studies on Angiogenic molecules and DNA binding proteins - Professor K.R. Acharya, Biology and Biochemistry, University of Bath.
  • Comparative genomics and complementary studies on Zebrafish models - Dr Greg Elgar, Reader QMW, London and Dr Anand Chandrasekhar, Assoc Professor, University of Missouri, Columbia, USA.

 

Current Research Interests

Multi-cellular organisms including mammals begin life as a single cell, the fertilized egg, which undergoes a series of changes to give rise to the complex adult organism. This includes growth, division, cell migration and morphogenesis. These events are highly regulated and organised both spatially and temporally. We are attempting to understand the molecular basis underlying these events in murine organogenesis. There are three major areas of research in my laboratory:

  • Stem cells and the molecular and cellular basis for the co-ordinated regulation of proliferation, cell differentiation and patterning in the intestinal epithelium
  • The Role of the Cdx, polycomb and trithorax group of genes in the regulation of axial skeletal and nervous system development
  • Angiogenins and cytotoxic RNAses in Disease and in health

Read about our work

New dementia research will use latest in stem cell technology

Study gives clues to causes of Motor Neurone Disease

Find 'offers motor neurone hope'

Discovery offers hope of halting Motor Neurone Disease progression

You can also watch a podcast of our motor neurone disease work.

Willing to supervise doctoral students

Enquires regarding Ph.D. opportunities are welcome. We are also open to collaborative PhD projects with other researchers or industrial partners.

Potential PhD projects are in the following areas

  • Modeling human diseases such as Ciliopathies and Motor neuron disease in  mice and fish (Zebrafish and Killifish)

  • Regulation of intestinal and brain stem cell Homeostasis

  • Development of the central nervous system

  • Stem cell derived organoid models of development and disease

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Projects

Research Output

Crystal structure of peptide-bound neprilysin reveals key binding interactions

Moss, S., Subramanian, V. & Acharya, K. R., 29 Feb 2020, In : FEBS Letters. 594, 2, p. 327-336 10 p.

Research output: Contribution to journalArticle

Mice with a conditional deletion of Talpid3 (KIAA0586) - a model for Joubert Syndrome

Bashford, A. L. & Subramanian, V., 18 Jul 2019, In : The Journal of Pathology. 248, 4, p. 396-408 13 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

The catalytic activity and secretion of zebrafish RNases are essential for their in vivo function in motor neurons and vasculature

Ferguson, R., Holloway, D. E., Chandrasekhar, A., Acharya, K. R. & Subramanian, V., 1 Feb 2019, In : Scientific Reports. 9, 1, p. 1-15 15 p., 1107.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
Open Access
File
1 Downloads (Pure)

A comparative bioinformatic analysis of C9orf72

Iyer, S., Acharya, K. R. & Subramanian, V., 19 Feb 2018, In : PeerJ. 6, 2, p. e4391 e4391.

Research output: Contribution to journalArticle

Open Access
  • 3 Citations (Scopus)